Medical Doctor (Ph.D.), Attending Physician, Master's Supervisor.

Graduated  from Jinan University in 2021. Engaged in clinical work related to  spinal surgery and orthopedics, familiar with the diagnosis and  treatment of spinal degenerative diseases and common orthopedic  diseases, focusing on minimally invasive spinal techniques. Proficient  in the diagnosis and treatment of orthopedic-related diseases such as  cervical spondylosis, lumbar disc herniation, lumbar spinal stenosis,  lumbar spondylolisthesis, and limb fractures. Hosts 4  provincial/ministerial and departmental-level research projects.  Published 6 SCI papers as first author. Serves as a committee member of  the Branch of Biomedical Materials and Clinical Applications, Guangdong  Society of Biomedical Engineering.

1. 2018-09 to 2021-06, Jinan University, Surgery, Ph.D.

2. 2015-09 to 2018-06, Jinan University, Surgery, Master's

3. 2009-09 to 2014-06, Guangdong Medical College, Clinical Medicine, Bachelor's

2021-08 to present, Employed in the Department of Spinal Surgery, The First Affiliated Hospital of Jinan University

Clinical Work:  Engaged in clinical work related to spinal surgery and orthopedics,  familiar with the diagnosis and treatment of spinal degenerative  diseases and common orthopedic diseases, focusing on minimally invasive  spinal techniques. Proficient in the diagnosis and treatment of  orthopedic-related diseases such as cervical spondylosis, lumbar disc  herniation, lumbar spinal stenosis, lumbar spondylolisthesis, and limb  fractures.
Scientific Research:  Focuses on neural injury and repair, elucidating the relationship  between microtubule-interacting proteins and neuronal growth and  regeneration. Investigates the roles of microtubule polymerization  proteins (CRMPs) and microtubule-severing proteins (Spastin) and their  modifications in neuronal growth and regeneration.

1. Zhenbin Cai;  Hui Wu; Tao Jiang; Ao Ma; Zhichao Meng; Jiehao Zhu; Hongsheng Lin;  Yaozhong Liang; Guowei Zhang; Minghui Tan. The Cullin3-Ring E3 ubiquitin  ligase complex and USP14 regulate spastin-mediated microtubule severing  and promotion of neurite outgrowth[J]. Neural Regen Res. 2026, 21(4):  1641-1651.

2. Zhenbin  Cai; Xiaonan Zhu; Guowei Zhang; Fengming Wu; Hongsheng Lin; Minghui  Tan. Ammonia induces calpain-dependent cleavage of CRMP-2 during neurite  degeneration in primary cultured neurons[J]. Aging, 2019, 11(12):  4354-4366.

3. Tao  Jiang; Zhenbin Cai; Zhisheng Ji; Jianyu Zou; Zhi Liang; Guowei Zhang;  Yaozhong Liang; Hongsheng Lin; Minghui Tan. The lncRNA  MALAT1/miR-30/Spastin Axis Regulates Hippocampal Neurite Outgrowth[J].  Front Cell Neurosci, 2020, 14: 555747.

4. Jianyu  Zou; Zhenbin Cai; Zhi Liang; Yaozhong Liang; Guowei Zhang; Jie Yang;  Yunlong Zhang; Hongsheng Lin; Minghui Tan. Different fusion tags affect  the activity of ubiquitin overexpression on spastin protein  stability[J]. European Journal of Histochemistry, 2021, 65(4): 3352.

5. Jie  Yang; Yunlong Zhang; Zhenbin Cai; Jianyu Zou; Shaojin Li; Guiqiang  Miao; Hongsheng Lin; Xiaodong Zhao; Minghui Tan. Inhibition of spastin  impairs motor function recovery after spinal cord injury. Brain Research  Bulletin, 2023, 205(-): 110806.

6. Shaojin  Li; Yaozhong Liang; Jianyu Zou; Zhenbin Cai; Hua Yang; Jie Yang;  Yunlong Zhang; Hongsheng Lin; Guowei Zhang; Minghui Li; SUMOylation of  microtubule-cleaving enzyme KATNA1 promotes microtubule severing and  neurite outgrowth[J]. J Biol Chem, 2022, 298(9): 102292.

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1. Guangdong Basic  and Applied Basic Research Foundation, Regional Joint Fund-Youth Fund  Project, 2022A1515111096, Mechanism of USP14 inhibiting Spastin  ubiquitination modification in spinal cord injury repair, 100,000 CNY,  Ongoing, Host (PI).

2. Guangzhou  Science and Technology Bureau, Guangzhou Basic and Applied Basic  Research Project, 2023A04J1285, Role and mechanism of KATNA1 SUMOylation  modification in spinal cord injury repair, 50,000 CNY, Ongoing, Host  (PI).

3. Guangdong  Medical Research Fund Project, A2023147, Mechanism of CRMP3 and KATNA1  interaction regulating microtubule dynamics in spinal cord injury  repair, 10,000 CNY, Ongoing, Host (PI).

4. Jinan  University, Jinan University Central University Basic Research  Business (Funds), 21622310, Mechanism of UCHL1 regulating microtubule  dynamics (participating in) spinal cord injury repair, Concluded, Host  (PI).

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