医学博士，副主任医师，硕士研究生导师

作为ICU医生，从事临床工作10余年，具备扎实的重症医学临床功底与丰富的麻醉学科背景，擅长各种疑难危重患者的救治。

本人长期聚焦脓毒症及相关器官功能损伤与保护的临床和基础研究，相关科研成果发表于JAMA、Intensive Care Medicine、Critical Care、Anesthesiology、British Journal of Anaesthesia、Journal of Nanobiotechnology等高影响力期刊。3项代表性成果获国际脓毒症权威指南《Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock》引用，多项学术成果被纳入国内外临床实践指南。H指数为29，且连续4年（2022-2025）入选全球前2%顶尖科学家“年度科学影响力排行榜”，2025年入选“终身科学影响力排行榜”。作为项目负责人，主持国家自然科学基金面上项目1项，同时承担多项省、市级科研课题。

《Journal of Critical Care》统计学编辑

《European Journal of Anaesthesiology》助理编辑

《Journal of Intensive Medicine》青年编辑

2007.09-2012.06，广西医科大学，本科，临床医学

2012.09-2015.06，广西医科大学，硕士，麻醉学

2022.09-2024.12，暨南大学，博士，重症医学

2015.08-2022.06，南京鼓楼医院，麻醉手术科，主治医师

2024.12至今，暨南大学附属第一医院，重症医学科，副主任医师

脓毒症及多器官功能障碍

H指数29，研究成果广泛应用于国内外多个指南，如SSC脓毒症指南等，近三年代表作如下：

1.Gu WJ（第一作者）, Cen Y, Zhao FZ, Wang HJ, Yin HY, Zheng XF. Association between driving pressure-guided ventilation and postoperative pulmonary complications in surgical patients: a meta-analysis with trial sequential analysis. Br J Anaesth. 2024 Sep;133(3):647-657. doi: 10.1016/j.bja.2024.04.060.

2.Gu WJ（第一作者）, Zhao FZ, Huang W, Zhu MG, Huang HY, Yin HY, Chen T. Selenium nanoparticles activate selenoproteins to mitigate septic lung injury through miR-20b-mediated RORγt/STAT3/Th17 axis inhibition and enhanced mitochondrial transfer in BMSCs. J Nanobiotechnology. 2025 Mar 20;23(1):226. doi: 10.1186/s12951-025-03312-2.

3.Gu WJ（第一作者）, Zhao FZ, Piccioni F, Shi R, Si X, Chen S, Cecconi M, Yin HY. Individualized PEEP titration by lung compliance during one-lung ventilation: a meta-analysis. Crit Care. 2025 Jan 15;29(1):27. doi: 10.1186/s13054-024-05237-y.

4.Gu WJ（第一作者）, Lyu J, Yin HY. Intrapartum Azithromycin vs Placebo for Neonatal Sepsis. JAMA. 2023 Jul 11;330(2):187-188. doi: 10.1001/jama.2023.8328.

5.Zhao FZ, Li LZ, Luo PY, Duan XJ, Huang SF, Yin HY, Gu WJ（通讯作者）. Ciprofol versus propofol for long-term sedation in mechanically ventilated patients with sepsis: a randomized controlled trial. BMC Anesthesiol. 2025 Apr 9;25(1):161. doi: 10.1186/s12871-025-03042-w.

6.Jin J, Dong Y, Huang Y, Wu L, Yu L, Sun Y, Zhou Q, Yin HY, Gu WJ（通讯作者）. ERRα Knockout Promotes M2 Microglial Polarization and Inhibits Ferroptosis in Sepsis-Associated Brain Dysfunction. Mol Neurobiol. 2025 Sep;62(9):11834-11847. doi: 10.1007/s12035-025-05005-1.
7.Li LZ,Gu WJ（第一作者）, Yuan XK, Fan WM, Zhang LM, Qu ZK, Zhao FZ, Yin HY. Blocking the ADAM9/ITGAV Pathway Ameliorates Sepsis-Induced Acute Lung Injury by Promoting Macrophage Efferocytosis. FASEB J. 2025 Aug 15;39(15):e70845. doi: 10.1096/fj.202501079R.
8.Gu WJ（第一作者）, Cen Y, Zhao FZ, Wang HJ, Yin HY, Zheng XF. Association between driving pressure-guided ventilation and postoperative pulmonary complications in surgical patients: a meta-analysis with trial sequential analysis. Br J Anaesth. 2024 Sep;133(3):647-657. doi: 10.1016/j.bja.2024.04.060.

9.Zhao FZ,Gu WJ（第一作者）, Li LZ, Qu ZK, Xu MY, Liu K, Zhang F, Liu H, Xu J, Yin HY. Cannabinoid receptor 2 alleviates sepsis-associated acute lung injury by modulating maturation of dendritic cells. Int Immunopharmacol. 2023 Oct;123:110771. doi: 10.1016/j.intimp.2023.110771.

10.Zheng XL,Gu WJ（第一作者）, Zhang F, Zhao FZ, Li LZ, Huang HY, Li LJ, Yi YH, Yin HY, Xu J. Exosomal miR-127-5p from BMSCs alleviated sepsis-related acute lung injury by inhibiting neutrophil extracellular trap formation. Int Immunopharmacol. 2023 Oct;123:110759. doi: 10.1016/j.intimp.2023.110759.
11.Gu WJ（第一作者）, Zhang LM, Wang CM, Zhao FZ, Yin HY, Lyu J. Pre-intensive care unit use of selective serotonin reuptake inhibitors and mortality in critically ill adults with mental disorders: analysis from the MIMIC-IV database. Transl Psychiatry. 2023 Jun 6;13(1):187. doi: 10.1038/s41398-023-02487-2.
12.Zhang L, Gu WJ（第一作者）, Huang T, Lyu J, Yin H. The Timing of Initiating Hydrocortisone and Long-term Mortality in Septic Shock. Anesth Analg. 2023 Oct 1;137(4):850-858. doi: 10.1213/ANE.0000000000006516.

国家自然科学基金面上项目

镁调控巨噬细胞有氧糖酵解-HMGB1乳酸化修饰改善脓毒症急性肾损伤的机制研究

主持，49万，2026.01 - 2029.12。

本科课程《医学职业素养与能力》

硕士课程《重症医学》、《急诊医学》

博士课程《重症医学进展》、《急诊医学》

广东省医学会重症医学分会青年委员

中国研究型医院学会危重医学专业委员会青年委员

广东省病理生理学会危重病专委会副秘书长

等