Our research aims to understand the concepts and mechanisms of  actin cytoskeleton dynamics, programmed cell death, and fission yeast. We use creative thinking as well as advanced research techniques (eg. Microscopes, Image Analysis) to explore and investigate our scientific hypotheses.

University: National University of Singapore, Singapore

Degree: PhD, August 2009 - March 2014

University: Sun Yat-sen University, Guangzhou, China

Degree: Bachelor, September 2005 - June 2009

University: Jinan University, Guangzhou, China

Position: Associate Professor, March 2017 - Now

University: Warwick Medical School, University of Warwick, UK

Position: Research Fellow, April 2014 - January 2017

Institute: Mechanobiology Institute, National University of Singapore, Singapore

Position: Research Assistant, August 2013 - March 2014

Institute: Temasek Life Sciences Laboratory, National University of Singapore, SingaporeWhere PhD work was done, August 2009 - August 2013

Actin Cytoskeleton, Programmed Cell Death, and Fission Yeast

1. Huang J*, Huang Y*, Yu H, Subramanian D, Padmanabhan A, Thadani R, Tao Y, Tang X, Wedlich-Soldner R, Balasubramanian MK. 2012. Nonmedially assembled F-actin cables incorporate into the actomyosin ring in fission yeast. Journal of Cell Biology. 199(5): 831-47. DOI: 10.1083/jcb.201209044 (Highlighted by JCB; Recommended by Faculty of 1000)

2. Huang J*†, Chew TG*†, Gu Y, Palani S, Kamnev A, Martin DS, Carter NJ, Cross RA, Oliferenko S, Balasubramanian MK†. 2016. Curvature-induced expulsion of actomyosin bundles during cytokinetic ring contraction. eLife. DOI: 10.7554/eLife.21383

3. Chew TG*†, Huang J*†, Palani S, Sommese R, Kamnev A, Gu Y, Oliferenko S, Sivaramakrishnan S, Balasubramanian MK†. 2017. Actin turnover maintains actin filament homeostasis during cytokinetic ring contraction. Journal of Cell Biology. DOI: 10.1083/jcb.201701104

4. Tang X, Huang J, Padmanabhan A, Bakka K, Bao Y, Tan BY, Cande WZ, Balasubramanian MK. 2011. Marker reconstitution mutagenesis: a simple and efficient reverse genetic approach. Yeast. 28(3): 205-12. DOI: 10.1002/yea.1831

5. Subramanian D*, Huang J*, Sevugan M, Robinson RC, Balasubramanian MK, Tang X. 2013. Insight into Actin Organization and Function in Cytokinesis from Analysis of Fission Yeast Mutants. Genetics. 194: 435-446. DOI: 10.1534/genetics.113.149716

6. Mishra M, Huang J, Balasubramanian MK. 2014. The yeast actin cytoskeleton. FEMS Microbiology Reviews. 38(2): 213-27. DOI: 10.1111/1574-6976.12064

7. He R, Wang Z, Lu Y, Huang J, Ren J, Wang K. 2015. Chaperonin containing T-complex polypeptide subunit eta is a potential marker of joint contracture: an experimental study in the rat. Cell Stress Chaperones. 20(6): 959-66. DOI: 10.1007/s12192-015-0624-x

8. Wang S, Thiyagarajan S, Chew TG, Huang J, Palani S, Kamnev A, Gu Y, Oliferenko S, Balasubramanian MK, O’Shaughnessy B. 2017. Component turnover in the cytokinetic ring maintains organizational homeostasis and tension production. Biophysical Journal. DOI: 10.1016/j.bpj.2016.11.2303

9. He R, Lu Y, Ren J, Wang Z, Huang J, Zhu L, Wang K. 2017. Decreased fibrous encapsulation and enhanced osseointegration in vitro by decorin-modified titanium surface. Colloids and Surfaces B: Biointerfaces. 155: 17-24. DOI: 10.1016/j.colsurfb.2017.03.055

10. Chew T, Lim T, Osaki Y,Huang J, Kamnev A, Hatano T, Osumi M, Balasubramanian MK. 2020. Inhibition of cell membrane ingression at the division site by cell wall in fission yeast. Molecular Biology of the Cell. DOI: 10.1091/mbc.E20-04-0245

11. Fan Z, Tian Y, Chen Z, Liu L, Zhou Q, He J, Coleman J, Dong C, Li N, Huang J, Xu C, Zhang Z, Gao S, Zhou P, Ding K, Chen L†. 2020. Blocking interaction between SHP2 and PD-1 denotes a novel opportunity for developing PD-1 inhibitors. EMBO Molecular Medicine. DOI: 10.15252/emmm.201911571

12. Ren W*, Zhao W*, Cao L†, Huang J†. 2021. Involvement of the Actin Machinery in Programmed Cell Death. Frontiers in Cell and Developmental Biology. DOI: 10.3389/fcell.2020.634849

13. Liu Y, Tu C, Guo X, Wu C, Gu C, Lai Q, Fang Y, Huang J, Wang Z, Li A, Liu S†. 2021. Tumor-suppressive Function of EZH2 Is through Inhibiting Glutaminase. Cell Death & Disease. DOI: 10.1038/s41419-021-04212-7

14. Huang J*, Wu R*, Chen L, Yang Z, Yan D†, Li M†. 2022. Understanding Anthracycline Cardiotoxicity from Mitochondrial Aspect. Frontiers in Pharmacology. DOI: 10.3389/fphar.2022.811406 (Highly Cited Paper, Web of Science) 

15. Thiyagarajan S, Wang S, Chew TG, Huang J, Balasubramanian MK, O’Shaughnessy B†. 2022. Myosin turnover controls actomyosin contractile instability. Proceedings of the National Academy of Sciences of the United States of America (PNAS). DOI: 10.1073/pnas.2211431119

16. Zhu S*, Hou J*, Liu C*, Liu P, Guo T, Lin Z, Wang X, Wu C, Huang D, Huang J, Wang Z†, He R†. 2022.An engineered tenogenic patch for the treatment of rotator cuff tear. Materials & Design. DOI: 10.1016/j.matdes.2022.111402

17. Hou J*, Zhu S*, Li Y, Chen X, Dai Z, Qiao M, Fan S,Huang J†, He R†. 2025. Activation of the NRF2/SLC7A11/GPX4 Axis Mitigates Arthrofibrosis by Suppressing Myofibroblast Ferroptosis through Oxidative Stress Regulation. Cell Investigation. DOI: 10.1016/j.clnves.2025.100020

18. Qiao M*, Fang Y*, Huang J†. 2025. Triaptosis: Pro-oxidant-induced programmed cell death. The Innovation Life. DOI: 10.59717/j.xinn-life.2025.100126

19. Qiao M*, Yuan Z*, Huang JW, Fang Y, Li Y†, Guo Y†, Huang J†. 2025. pH-Regulated Nuclear F-Actin Assembly during Ferroptosis. Frontiers in Cell and Developmental Biology. DOI: 10.3389/fcell.2025.1699698

20. Huang JW, Xie Y†, Xiang F†, Huang J†. 2026. Editorial: Ferroptosis, cuproptosis, and triaptosis: unveiling pathways and translational prospects. Frontiers in Cell and Developmental Biology. DOI: 10.3389/fcell.2026.1778698

21. Qiao M*, Zhou L*, Zhou M, Fang Y, Mai H, Cao L, Xu K, Sang Y, Chen M, Huang JW, Huang P, Yan Z, Wang C, Dai Z, Huang D, He R, Pang L†, Guo Y†, Chew T†,Huang J†. 2026. ERM Inhibition Confers Ferroptosis Resistance through ROS-Induced NRF2 Signaling. Advanced Science. DOI: 10.1002/advs.202513310 (Selected as Back Cover Feature) 

22. Huang J*, Mishra M*, Palani S, Chew TG, Balasubramanian MK. 2016. Isolation of cytokinetic actomyosin rings from Saccharomyces cerevisiae and Schizosaccharomyces pombe. Methods in Molecular Biology. Springer Nature. 1369: 125-36. DOI: 10.1007/978-1-4939-3145-3_10

23. Huang D*, Lin R*, Liu S, Zhong H, Dai Z, Huang J†. 2022. Migrasome in cell movement: new horizon for cell signaling. Chapter of “Cell Movement in Health and Disease”. Elsevier. DOI: 10.1016/b978-0-323-90195-6.00006-1

24. Zhao W*, Ren W*, Huang D, Sang Y, Cao L, Huang J†. 2022. Cell Structure and Physiology. First chapter of “Cell Movement in Health and Disease”. Elsevier. DOI: 10.1016/B978-0-323-90195-6.00007-3

25. Dai Z*, Zhang W*, Zhou L, Huang J†. 2023. Probing lipid peroxidation in ferroptosis: emphasizing the utilization of C11-BODIPY-based protocols. Methods in Molecular Biology. Springer Nature. DOI: 10.1007/978-1-0716-3433-2_6

ZL202310489614.X、ZL202310062933.2、 ZL202311009172.0、ZL201921931845.7

Molecular Genetics Methods, Medical Biology

First Editorial Board Member of Cell Investigation. Founding Member and Inaugural Vice President of the National University of Singapore Shenzhen Alumni Association. Committee Member of the Preparatory Committee of the (Singapore) Sun Yat-sen University Alumni Association. Serving as a peer reviewer for academic journals including Advanced Science, Protein & Cell, Acta Pharmaceutica Sinica B, and iScience.