Professor Shikai Jin received his bachelor’s degree from Chu Kochen Honors College in Zhejiang University, and conducted computational biology research during his doctoral studies at Rice University in the United States. From 2023 to 2025, he worked at Gilead Sciences, a leading virology-focused multinational pharmaceutical company in the San Francisco Bay Area, where he was engaged in AI-driven antibody development and clinical trial-related research.

Prof. Jin specializes in applying advanced artificial intelligence models to address key challenges in macromolecular design and clinical trials. His research mainly focuses on using molecular dynamics simulations and deep learning architectures, including convolutional neural networks and Transformers, to investigate protein folding mechanisms and protein structure–function relationships. His related work has been published in renowned journals such as Nature Chemical Biology, Nature Communications, and PNAS. Before returning to China, he had contributed to nearly 20 publications and received several national-level awards, including the Chinese Government Award for Outstanding Self-Financed Students Abroad and the Outstanding Achievement Award of the “Chunhui Cup” Innovation and Entrepreneurship Competition.

Sep 2013 - Jun 2017, B.S. in Life Sciences, Chu Kochen Honors College, Zhejiang University, China

Aug 2017 - May 2023, M.S. in Computer Science, Rice University, United States

Aug 2017 - May 2023, Ph.D. in Biochemistry and Cell Biology, Rice University, United States

May 2023 - Dec 2025, Data Scientist (Senior Manager Level), Gilead Sciences, San Francisco Bay Area, United States

[1] Jin S, Bueno C, Lu W, Wang Q, Chen M, Chen X, Wolynes PG, Gao Y^*. Computationally exploring the mechanism of bacteriophage T7 helicase translocating along ssDNA. Proc Natl Acad Sci U S A. 2022; 119(32):e2202239119. doi: 10.1073/pnas.2202239119

[2] Jin S^#, Chen M^#, Chen X^#, Bueno C, Lu W, Schafer NP, Lin X, Onuchic JN, Wolynes PG^*. Protein structure prediction in CASP13 using AWSEM-Suite. J Chem Theory Comput. 2020; 16(6):3977-3988. doi: 10.1021/acs.jctc.0c00188 (Cover Story)

[3] Yang S^#, Jin S^#, Zhang M^#, Chen Y, Guo Y, Hu Y, Wolynes PG^*, Xiao H^*. Real-time imaging of protein microenvironment changes in cells with rotor-based fluorescent amino acids. Nat Chem Biol. 2026; 22(1): 97-108. doi: 10.1038/s41589-025-02003-1

[4] Chen X^#, Jin S^#, Chen M^#, Bueno C, Wolynes PG^*. The marionette mechanism of domain-domain communication in the antagonist, agonist and coactivator responses of the estrogen receptor. Proc Natl Acad Sci U S A. 2023; 120(6):e2216906120. doi: 10.1073/pnas.2216906120

[5] Xu L^#, Jin S^#, Urem M, Chen X, Lee S-J, Lamers MH, Wolynes PG^*, Wuite GJL^*. DNA polymerase actively and sequentially displaces single-stranded DNA-binding proteins. Nat Commun. 2025; 16(1):7431. doi: 10.1038/s41467-025-62531-1

^#denotes for co-first author, ^*denotes for co-corresponding author.

Bioinformatics (Undergraduate Level)

Mar 2026 - Present, Council Member, Biophysical Society of Guangdong Province