研究方向为肿瘤、感染等疾病中关键炎症信号和免疫反应的分子机制研究；免疫治疗技术和活性生物材料研发等。总共发表各类论文45篇, 论文累计被引用超过2800次，H指数为23 (Google Scholar)。以第一作者或通讯作者先后在Nat Commun, Sig Transduct Targ Ther，Protein & Cell, Canc Res，PLoS Pathog，J Biol Chem, J Immunol等权威SCI杂志发表论文24篇；其中影响因子大于10分的论文7篇，包含两篇Nature子刊。主持承担各类科研项目共12项，其中包含2项国家自然科学基金，3项省部级项目。获得国家发明专利授权8项。

2007/9 - 2012/12，武汉大学，生命科学学院，病毒学国家重点实验室，博士（硕博连读）

2003/9 - 2007/7，武汉大学，生命科学学院，生命科学与技术基地班，本科

2019/01 - 至今，暨南大学，病原微生物研究院，副教授

2013/01 – 2018/12，华中科技大学，同济医学院附属协和医院，助理研究员

病毒感染、肿瘤等疾病过程中的炎症与免疫反应；活性生物材料的研究与应用。

(1) SARS-CoV-2 N protein promotes the NLRP3 inflammasome to induce hyperinflammation. Pan Pan^#, Miaomiao Shen^#, Zhenyang Yu^#, Weiwei Ge, Keli Chen, Minfu Tian, Feng Xiao, Zhenwei Wang, Jun Wang, Yaling Jia, Wenbiao Wang, Pin Wan, Jing Zhang, Weijie Chen, Zhiwei Lei, Xin Chen, Zhen Luo, Qiwei Zhang, Meng Xu¹, Geng Li*, Yongkui Li*, and Jianguo Wu*. Nature Communications. 2021, 12:4664  (共通讯，IF =14.7，A1一区, Top)

(2) SARS-CoV-2 N protein enhances the anti-apoptotic activity of MCL-1 to promote viral replication. Pan Pan^#*, Weiwei Ge^#, Zhiwei Lei^#, Wei luo^#, Yuqing Liu, Zhanwen Guan, Lumiao Chen, Zhenyang Yu, Miaomiao Shen, Dingwen Hu, Qi Xiang, Wenbiao Wang, Pin Wan, Mingfu Tian, Yang Yu, Zhen Luo, Xulin Chen, Heng Xiao, Qiwei Zhang, Xujing Liang, Xin Chen*, Yongkui Li*, Jianguo Wu. Signal Transduction and Targeted Therapy. 2023, 8:194. (通讯，IF=40.8，A1一区, Top)

(3) The R203M and D377Y mutations of the nucleocapsid protein promote SARS-CoV-2 infectivity by impairing RIG-I-mediated antiviral signaling. Yongkui Li^#, Moran Li^#, Heng Xiao^#, Feng Liao^#, Miaomiao Shen^#, Weiwei Ge, Junxian Ou, Yuqing Liu, Lumiao Chen, Yue Zhao, Pin Wan, Jinbiao Liu, Jun Chen, Xianwu Lan, Shaorong Wu, Qiang Ding, Geng Li*, Qiwei Zhang*, Pan Pan*. PLoS Pathog. 2025 Jan 22;21(1):e1012886. (一作，IF = 5.5, A1一区, Top)

(4) A programmable DNA nanodevice for colorimetric detection of DNA methyltransferase activity using functionalized hemin/G-quadruplex DNAzyme. Wenxu Yuan, Kaiting Xiao, Xingxing Liu, Yanming Lai, Fazeng Luo, Wei Xiao, Jinjun Wu, Pan Pan*, Yongkui Li*, Heng Xiao*. Analytica Chimica Acta. 2023, 1273:341559. (共通讯，IF=5.7, A1一区, Top)

(5) IL33 Promotes Colon Cancer Cell Stemness via JNK Activation and Macrophage Recruitment. Min Fang^#, Yongkui Li^#, Kai Huang^#, Shanshan Qi, Jian Zhang,Witold Zgodzinski, Marek Majewski, Grzegorz Wallner, Stanislaw Gozdz, Pawel Macek, Artur Kowalik, Marcin Pasiarski, Ewelina Grywalska, Linda Vatan, Nisha Nagarsheth,Wei Li, Lili Zhao, Ilona Kryczek, Guobin Wang, Zheng Wang, Weiping Zou, and Lin Wang. Cancer Research. 2017 May 15;77(10):2735-2745. (共一作，IF = 12.5，A1一区，Top)  

(6) IL-33 facilitates proliferation of colorectal cancer dependent on COX2/PGE2. Yongkui Li^#, Jie Shi^#, Shanshan Qi, Jian Zhang, Dong Peng, Zhenzhen Chen, Guobin Wang*, Zheng Wang*, and Lin Wang*. Journal of Experimental & Clinical Cancer Research (2018) 37:196. (一作，IF =11.3，A1一区，Top) 

(7) MicroRNA-548 down-regulates host antiviral response via direct targeting of IFN-lambda1. Yongkui Li, Jiajia Xie, Xiupeng Xu, Jun Wang, Fang Ao, Yushun Wan, Ying Zhu*. Protein & Cell. 2013; 4 (2): 130-41. (一作，IF = 13.6，A1一区)

(8) Inducible IL-32 exerts extensive antiviral function via selective stimulation of IFN-lambda1. Yongkui Li^#, Jiajia Xie^#, Xiupeng Xu, Li Liu, Yushun Wan, Yingle Liu, Zhu Ying*. Journal of Biological Chemistry. 2013; 288(29):20927–41. (一作，IF = 4，A1二区，Top)

(9) Sericin and sericin-derived peptide alleviate viral pathogenesis in mice though inhibiting lactate production and facilitating antiviral response. Yongkui Li^#, Ying Huang^#, Pan Pan^#, Xu Che, Yaru Zhang, Yeshun Zhang, Algahtany Amal, Xin Li, Wenjing Niu, Nachuan Luo, Wen Zhang, Daolong Gao, Qiuping Tan, Qiwei Zhang, Xiwen Xing*, Zhen Luo*, and Jianguo Wu*. Applied Materials Today, 2021, 25:101256. (一作，IF =7.2，A1二区)

(10) Hydrogel dual delivered celecoxib and anti-PD-1 synergistically improve antitumor immunity. Yongkui Li^#, Min Fang^#, Jian Zhang, Jian Wang, Yu Song, Jie Shi, Wei Li, Gang Wu, Jinghua Ren, Zheng Wang, Weiping Zou, and Lin Wang. Oncoimmunology. 2015 Aug 12;5(2):e1074374. (一作, IF = 6.5，A1二区)

(11) Uhrf1-Mediated Tnf-α Gene Methylation Controls Proinflammatory Macrophages in Experimental Colitis Resembling Inflammatory Bowel Disease. Qi Shanshan^#, Li Yongkui^#, Dai Zhen, Xiang Mengxi, Wang Guobin, Wang Lin, Wang Zheng. Journal of Immunology. 2019 Dec 1;203(11):3045-3053. (共一作, IF = 3.6，A2三区)

(12) Editorial: The role ofinflammasome in viral infection, volume II. Pin Wan^#, Pan Pan^#, Binlian Sun* and Yongkui Li*. Frontiers in Cellular and Infection Microbiology. 2024; 14:1438310.(通讯，IF = 4.6，A1二区)

(13) NNNPERFUME: detection of 8-oxoguanine DNA glycosylase activity based on Primer exchange reaction and functionalized hemin/G-quadruplex DNAzyme. Kaiting Xiao^#, Yanming Lai^#, Xingxing Liu, Shengjie Li, Wenxu Yuan, Ziyun Wang, Pan Pan *, Yongkui Li *, Heng Xiao *.Talanta Open. 2024; 9 :100288. (共通讯，新刊IF暂无)

(14) The role of inflammasome in chronic viral hepatitis. Pin Wan^#, Ge Yang^#, Qi Cheng^#, Xuelong Zhang, Zhaoyang Yue, Moran Li, Chunlin Liu, Qian Yi, Yaling Jia, Jinbiao Liu, Xiwen Xing*, Binlian Sun*, Yongkui Li*. Frontiers in Cellular and Infection Microbiology.2024; 14:1382029. (通讯，IF = 4.6，A1二区)

(15) The role of inflammasome in viral infection. Pin Wan, Yaru Zhang, Pan Pan*, Yongkui Li*. Frontiers in Cellular and Infection Microbiology, 2023, 13:1260013. (通讯，IF = 4.6，A1二区)

(16) In Memory of the Virologist Jianguo Wu, 1957–2022. Ge Yang^#, Zhaoyang Yue^#, Pan Pan*, Yongkui Li*. Viruses, 2023,15, 1754. (通讯，IF =3.8，A2三区)

(17) The roles of critical pro-inflammatory cytokines in the drive of cytokine storm during SARS-CoV-2 infection. Muhammad Suhaib Qudus, Mingfu Tian, Summan Sirajuddin, Siyu Liu, Uzair Afaq, Muneeba Wali, Jinbiao Liu, Pan Pan, Zhen Luo, Qiwei Zhang, Ge Yang*, Pin Wan*, Yongkui Li*, Jianguo Wu. Journal of Medical Virology. 2023, 95:e28751. (通讯，IF = 6.8，A2三区)

(18) Inhibition of PIKFYVE kinase interferes ESCRT pathway to suppress RNA virus replication. Zhen Luo, Yicong Liang, Mingfu Tian, Rui Su, Muhammad Adnan Shereend, Jialing Yin, Zhihui Ruan, Kailang Wu, Jun Guo, Qiwei Zhang*, Yongkui Li*, and Jianguo Wu*. Journal of Medical Virology. 2023, 95(2): e28527. (共通讯，IF =6.8，A2三区)

(19) Natural Oncolysis of Enterovirus 71 in Antitumor Therapy of Colorectal Cancer. Zhihui Ruan, Jiangyang Chi, Yue Kong, Chengcheng Li, Xiaolan Ruan, Xing Zhou, Yanxi Chen, Yongkui Li*, and Zhen Luo*. Advanced Biology. 2023, 2200336. (共通讯, IF = 3.7，A2三区)

(20) Innate Immunity, Inflammation, and Intervention in HBV Infection. Ge Yang^#, Pin Wan^#, Yaru Zhang, Qiaoru Tan, Muhammad Suhaib Qudus, Zhaoyang Yue, Wei Luo, Wen Zhang, Jianhua Ouyang, Yongkui Li*, Jianguo Wu. Viruses. 2022, 14, 2275. (通讯，IF =3.8，A2三区)

(21) G-Quadruplex Linked DNA Guides Selective Transfection into Nucleolin-Overexpressing Cancer Cells. Mengxi Xiang^#, Yongkui Li^#, Jia Liu, Jie Shi, Yizhi Ge, Chen Peng, Yawen Bin, Zheng Wang*, Lin Wang*. Pharmaceutics, 2022, 14, 2247. (共一作，IF = 4.9，A2三区)

(22) ASB17 facilitates the burst of LPS-induced inflammation through maintaining TRAF6 stability. Pin Wan^#, Ge Yang^#, Simeng Zhang, Yaru Zhang, Yaling Jia, Xu Che，Zhen Luo, Pan Pan, Geng Li, Xulin Chen, Qiwei Zhang, Wen Zhang, Qiuping Tan, Yongkui Li*, Jianguo Wu*. Frontiers in Cellular and Infection Microbiology, 2022, 12:759077. (通讯，IF = 4.6，A1二区)

(23) Targeting inhibition of Foxp3 by MMP2/9 sensitive short peptide linked P60 fusion protein 6 (P60-MMPs) to enhance anti-tumor immunity. Xiuli Ding^#, Chen Peng^#, Yongkui Li^#, Jia Liu, Yu Song, Bo Cai, Mengxi Xiang, Jian Zhang, Zheng Wang*, Lin Wang*. Macromolecular Bioscience. 2020 May 25:e2000098. (共一作，IF = 4.4，A2四区)

(24) Alginate Enhances Memory Properties of Antitumor CD8+ T Cells by Promoting Cellular Antioxidation. Yongli Fan^#, Yongkui Li^#, Jian Zhang, Xiuli Ding, Jinyuan Cui, Guobin Wang*, Zheng Wang*, Lin Wang*. ACS Biomaterials Science & Engineering 2019 Sep; 5(9): 4717-4725 (共一作，IF = 5.5，A1二区) 

1. 国家自然科学基金-面上项目，82472246，主持

2. 国家自然科学基金-青年科学基金项目，81502572，主持

3. 广东省自然科学基金-面上项目，2024A1515011433，主持

4. 广东省自然科学基金-面上项目，2020A1515010369，主持

5. 广州市基础研究计划-基础与应用基础研究项目，202102080419，主持

6. 百济神州公司-横向课题，40121219 ，主持

7. 龙帆宏盛生物医药（广东）有限公司-横向项目，主持

8. 暨南大学中央高校基本科研业务费专用项目，21623404，主持

9. 暨南大学中央高校基本科研业务费-跃升计划项目，主持

10. 暨南大学人才引进计划-第四层次人才支持项目，主持

1. 一种可介导生物大分子透皮吸收的组合剂、制备方法及应用，国家专利授权(专利号ZL202110377048.4)

2. S63845在制备抗新冠病毒感染药物中的应用，国家专利授权(专利号ZL202110377048.4)

3.  丝胶蛋白、提取方法、作为细胞抗病毒免疫增强剂和应用，国家专利授权（专利号ZL202010961734.1)

4.  一种含有胶原蛋白结合结构域的融合蛋白》，国家专利授权（专利号 ZL201610962104.X）

5.  丝胶蛋白水凝的制备方法及其应用》，国家专利授权（专利号 ZL201410071402.0）

6.塞来昔布的聚乙二醇修饰及连接叶酸基团的靶向药物分子及制备方法，国家专利授权(专利号ZL202210284132.6)

7. S63845在制备抗流感病毒感染药物中的应用，国家专利授权(专利号CN202211424357.3)

8. 一种外泌体检测方法 ，国家专利授权(专利号ZL2022 10674718.3)

《病原微生物学》《毒理学基础》《高级病毒学》

学术杂志Innovation (新刊IF=32.1)青年编委

Viruses杂志客座编辑

Front Cell Infect Microbiol杂志客座编辑

中国中医药信息学会中医临床药学分会，理事

广东省呼吸与健康学会疫苗专业委员会，会员

中国医疗保健国家交流促进会并临床工程与健康产业分会，委员

湖北医学生物免疫学会并再生医学与免疫专委会，常务委员

暨南大学生物医药产业园，研发科学家