研究病毒感染与宿主的天然免疫机制，病毒复制与细胞的相互关系，肠道炎症与肿瘤发生。主要从事RNA病毒，包括呼吸道病毒、肠道病毒、寨卡病毒等感染引起的宿主天然免疫反应的分子机制，抗病毒研究和病毒感染的肠道炎症反应，以及结直肠癌发生发展的分子机制。先后主持和参与项目10余项，主持国家自然科学基金青年项目1项，病毒学国家重点实验室开放课题1项，广东省自然科学基金面上项目1项。获授权国家发明专利2项。发表论文17篇，其中第一或通讯作者论文7篇，包括PLoS Pathogens（2篇），Nature Communications，Journal of Immunology，Journal of Infection等。

2009年9月—2014年12月 武汉大学，生命科学学院，微生物学，博士

2005年9月—2009年6月 湖北大学，生命科学学院，生物工程，学士

2018年1月—至今 暨南大学，病原微生物研究院，副教授

2014年7月—2017年12月 华中科技大学，同济医学院附属协和医院，助理研究员

主要从事（1）RNA病毒感染引起的宿主天然免疫反应的分子机制；（2）抗病毒研究和病毒感染的肠道炎症反应；（3）结直肠癌发生发展的分子机制。

[1] Zhu Chengliang^#, Liu Weiyong^#, Su Hanwen^#, Li Sitong, Shereen Muhammad Adnan, Lv Zhihua, Niu Zhili, Li Dong, Liu Fang, Luo Zhen*, Xia Yuchen*. Breastfeeding Risk from Detectable Severe Acute Respiratory Syndrome Coronavirus 2 in Breastmilk. Journal of Infection 2020; doi. 10.1016/j.jinf.2020.06.001. [IF:5.099]; 医学2区；共同通讯作者

[2] Luo Zhen^#, Su Rui^#, Wang Wenbiao^#, Liang Yicong, Zeng Xiaofeng, Shereen Muhammad Adnan, Bashir Nadia, Zhang Qi, Zhao Ling, Wu Kailang, Liu Yingle, Wu Jianguo*. EV71 infection induces neurodegeneration via activating TLR7 signaling and IL-6 production. PLoS Pathogens 2019; 15(11):e1008142. [IF:6.463]；医学1区；Top期刊；第一作者

[3] Li Jing^#, Hu Jia^#, Luo Zhen^#, Zhou Caihong, Huang Lifeng, Zhang Hongyan, Chi Jiangyang, Chen Zhenzhen, Li Qilin, Deng Meizhou, Chen Junhua, Tao Kaixiong, Wang Guobin*, Wang Lin*, Wang Zheng*. AGR2 is controlled by DNMT3a-centered signaling module and mediates tumor resistance to 5-Aza in colorectal cancer. Experimental Cell Research 2019; 385(1):111644. [IF:3.329]；医学3区；共同第一作者

[4] Wang Wenbiao^#, Li Geng^#, Wu De^#, Luo Zhen^#, Pan Pan, Tian Mingfu, Wang Yingchong, Xiao Feng, Wu Kailang, Liu Xiaohong, Rao Lang, Liu Fang*, Liu Yingle*, Wu Jianguo*. Zika Virus Infection Induces Host Inflammatory Responses by Facilitating NLRP3 Inflammasome Assembly and Interleukin-1β Secretion. Nature Communications 2018; 9(1):106. [IF:11.878]；综合1区；Top期刊；共同第一作者

[5] Luo Zhen, Ge Maolin, Chen Junbo, Geng Qibin, Qiao Zhi,Bai Lan, Zhang Qi, Zhu Chengliang, Xiong Ying, Wu Kailang, Liu Fang*, Liu Yingle*, Wu Jianguo*. HRS plays an important role for TLR7 signaling to orchestrate inflammation and innate immunity upon EV71 infection.PLoS Pathogens 2017; 13(8):e1006585.[IF:6.463]；医学1区；Top期刊；第一作者

[6] Ge Maolin^#, Luo Zhen^#, Qiao Zhi^#, Zhou Yao, Cheng Xin, Geng Qibin, Cai Yanyan, Wan Pin, Xiong Ying, Liu Fang, Wu Kailang*, Liu Yingle*, Wu Jianguo*. HERP binds TBK1 to activate innate immunity and repress virus replication in response to endoplasmic reticulum stress. Journal of Immunology 2017; 199(9):3280-3292.[IF:4.718]；医学2区；Top期刊；共同第一作者

[7] Luo Zhen, Dong Xingchen, Li Youxing, Zhang Qi, Kim Cholho, Song Yu, Kang Lei, Liu Yingle, Wu Kailang*, Wu Jianguo*. PolyC-binding protein 1 interacts with 5’-untranslated region of Enterovirus 71 RNA in membrane-associated complex to facilitate viral replication. PLoS One2014; 9(1):e87491. [IF:2.776]；综合3区；第一作者

[8] Huang Lifeng^#, Liu Zhibo^#, Hu Jia^#, Luo Zhen, Zhang Cheng, Wang Lin*, Wang Zheng*. MiR-377-3p Suppresses Colorectal Cancer Through Negative Regulation on Wnt/beta-catenin Signaling by Targeting XIAP and ZEB2. Pharmacological Research 2020; 156:104774. [IF:5.574]；医学2区；Top期刊

[9] You Lei^#, Chen Junbo^#, Liu Weiyong^#, Xiang Qi, Luo Zhen, Wang Wenbiao, Xu Wei, Wu Kailang, Zhang Qi*, Liu Yingle*, and Wu Jianguo*. Enterovirus 71 induces neural cell apoptosis and autophagy through promoting ACOX1 downregulation and ROS generation. Virulence 2020; 11(1):537-553. [IF:4.775]；生物 2区

[10] Jin Jing, Wang Wenbiao, Ai Sha, Liu Weiyong, Song Yu, Luo Zhen, Zhang Qi, Wu Kailang, Liu Yingle, Wu Jianguo*. Enterovirus 71 Represses Interleukin Enhancer-Binding Factor 2 Production and Nucleus Translocation to Antagonize ILF2 Antiviral Effects. Viruses. 2019;12(1). [IF:3.811]；医学2区

[11] Luo Danju, Deng Bin, Weng Mixia, LuoZhen, Nie Xiu*. A prognostic 4-lncRNA expression signature for lung squamous cell carcinoma. Artificial cells, Nanomedicine, and Biotechnology 2018; 46(6):1207-1214. [IF:4.139]；工程技术3区

[12] Han Yang, Wang Lvyin, Cui Jin, Song Yu, Luo Zhen, Chen Junbo, Xiong Ying, Zhang Qi, Liu Fang, Ho Wenzhe, Liu Yingle*, Wu Kailang*, Wu Jianguo*. SIRT1 inhibits EV71 genome replication and RNA translation by interfering with the viral polymerase and 5’UTR RNA. Journal of Cell Science 2016; 129:4534-4547. [IF:4.517]；生物2区；Top期刊

[13] Wang Zheng^*#, Wang Jian^#, Jin Yang^#, Luo Zhen, Yang Wen, Xie Hongjian, Huang Kai*, Wang Lin*. A Neuroprotective Sericin Hydrogel As an Effective Neuronal Cell Carrier for the Repair of Ischemic Stroke. ACS Applied Materials & Interfaces 2015; 7:24629-24640. [IF:8.456]；材料科学1区；Top期刊

[14] Bai Lan, Zhang Wei, Tan Li, Yang Hongchuan, Ge Maolin, Zhu Chengliang, Zhang Rui, Cao Yanhua, Chen Junbo, Luo Zhen, Ho Wenzhe, Liu Fang, Wu Kailang*, Wu Jianguo*. Hepatitis B virus hijacks CTHRC1 to evade host immunity and maintain replication. Journal of Molecular Cell Biology2015; 7(6):543-56. [IF:4.761]；生物2区

[15] Song Yu, Cheng Xin, Yang Xiaoxia, Zhao Rong, Wang Peili, Han Yang, Luo Zhen, Cao Yanhua, Zhu Chengliang, Xiong Ying, Liu Yingle, Wu Kailang, Wu Jianguo*.Early growth response-1 facilitates enterovirus 71 replication by direct binding to the viral genome RNA. International Journal of Biochemistry & Cell Biology2015; 62:36-46. [IF:3.144]；生物3区

[16] Li Youxing, Zhang Qi, Liu Yin, Luo Zhen, Kang Lei, Qu Jing, Liu Weiyong, Xia Xueshan, Liu Yingle, Wu Kailang, Wu Jianguo*. Hepatitis C virus activates Bcl-2 and MMP-2 expression through multiple cellular signaling pathways. Journal of Virology 2012; 86:12531-12543. [IF:4.324]；医学2区；Top期刊

[17] Kang Lei, Luo Zhen, Li Youxing, Zhang Wenjing, Sun Wei, Li Wei, Chen Yanni, Liu Fang, Xia Xueshan, Zhu Ying, Wu Jianguo*. Association of Vpu with hepatitis C virus NS3/4A stimulates transcription of type 1 human immunodeficiency virus. Virus Research 2012; 163(1):74-81. [IF:2.736]；医学3区

[1] 国家自然科学基金委员会，青年基金项目，31800147，肠道病毒71型诱导外泌体促进血脑屏障通透性的分子机制研究，2019-01至2021-12，25万元，在研，主持。

[2] 国家科技部，病毒学国家重点实验室开放课题，2019KF001，Toll样受体7介导肠道病毒71型引起的神经损伤的分子机制研究，2019-03至2021-02，6万元，在研，主持。

[3] 广东省自然科学基金委员会，面上项目，2019A1515011073，寨卡病毒激活星形胶质细胞中Toll样受体7通路影响神经发育的机制研究，2019-10至2022-09，10万元，在研，主持。

[4] 暨南大学人才引进项目, 2018-01至2021-01，20万元，在研，主持。

[1] 吴建国，邬开朗，葛茂林，乔智，罗震，谭秋萍，刘芳。一种同型半胱氨酸诱导的内质网蛋白在制备治疗或预防EV71感染药物中的应用。授权公告日：2018.02.13，授权公告号：CN103893171B，授权专利号：ZL201510398925.0。

[2] 邬开朗，吴建国，乔智，罗震，刘芳，金晶。肝细胞生长调节因子酪氨酸激酶底物在预防和/或治疗EV71感染中的应用。授权公告日：2017.10.03，授权公告号：CN103893171B，授权专利号：ZL2015102950520.0。

专业选修课，《病原微生物学》，2.0学分数，36学时。