郭豪 教授 个人简介

基本信息

中共党员，教授，暨南大学化学与材料学院。

教育经历

2020年6月 获中国科学院化学研究所博士学位（导师：王其强研究员），研究方向：超分子催化。

工作经历

2020.09-2021.07

南京药石科技股份有限公司 资深研究员

主持非共价KRAS G12D抑制剂（MRTX1133）的工艺研发与GMP生产，推动该抗癌药物进入临床I期试验。

2021.09-2024.09

德国马克斯·普朗克分子生理学研究所 博士后研究员，获勃林格殷格翰基金会 Plus 3 Perspectives 项目资助，合作导师：Charles C. J. Loh教授。

研究方向：新型非共价键催化糖苷化反应。

2025.03-至今

暨南大学化学与材料学院 教授、独立PI，组建“糖科学与精准合成”交叉研究团队。

研究方向：动态限域介导糖的区域/立体选择性合成，开发新型糖苷化催化策略，突破复杂糖链区域/立体选择性调控难题。

研究特色：

学科交叉：融合有机合成、超分子催化与糖化学，开发“动态限域空腔”催化新体系。

应用导向：面向抗肿瘤糖疫苗、抗菌糖类药物等重大需求，推动糖科学从基础研究到产业转化。

实验室理念

"解码糖质密码，创制健康未来"——以糖科学基础研究为引擎，驱动生物医药创新突破！

糖化学新型方法学与精准合成技术开发

1. Hao Guo, Charles C. J. Loh* Noncovalent Interactions: An emerging focal point in stereoselective catalytic carbohydrate synthesis. Carbohydr. Res. 2025, 552, doi.org/10.1016/j.carres.2025.109458. (Invited by editor).

2. Hao Guo, & Charles C. J. Loh*.Merging radical catalysis and noncovalent stereocontrol concepts to forge native O-glycosidic linkages. Sci. Bull. 2024, 69, 3308-3310.

3. Hao Guo, Dilber Tan, Christian Merten and Charles C. J. Loh* Enantioconvergent and Site-Selective Etherification of Carbohydrate Polyols through a Chiral Copper Catalyzed Radical Manifold.Angew. Chem. Int. Ed. 2024, 63, e202409530.

4. Hao Guo, Jan-Lukas Kirchhoff, Carsten Strohmann, Bastian Grabe & Charles C. J. Loh* Asymmetric Pd/Organoboron-Catalyzed Site-Selective Carbohydrate Functionalization with Alkoxyallenes Involving Noncovalent Stereocontrol.Angew. Chem. Int. Ed. 2024, 63, e202400912.

5. Hao Guo, Jan-Lukas Kirchhoff, Carsten Strohmann, Bastian Grabe & Charles C. J. Loh* Exploiting π- and chalcogen interactions for the β-selective 2-deoxyglycosylation of indoles through glycal conformational distortion.Angew. Chem. Int. Ed. 2024, 63, e202316667.

6. Hao Guo, Lie-Wei Zhang, Hao Zhou, Wei Meng, Yu-Fei Ao, De-Xian Wang, and Qi-Qiang Wang* Substrate Induced Dimerization Assembly of Chiral Macrocycle Catalysts toward Cooperative Asymmetric Catalysis.Angew. Chem. Int. Ed. 2020, 59, 2623–2627.

7. Shi-Xin Nie#, Hao Guo#(co-first authors), Teng-Yu Huang, Yu-Fei Ao, De-Xian Wang, Qi-Qiang Wang* Xenon binding by a tight yet adaptive chiral soft capsule. Nat. Commun.2020, 11, 6257.

8. Hao Guo, Yu-Fei Ao, De-Xian Wang, and Qi-Qiang Wang* Bioinspired tetraamino-bisthiourea chiral macrocycles in catalyzing decarboxylative Mannich reactions.Beilstein J. Org. Chem. 2022, 18, 486-496.(Invited to the thematic issue)

9. Hao Guo, Fen Xing, Guang-Fen Du*, Kuo-Wei Huang, Bin Dai* and Lin He* N-Heterocyclic Carbene-Catalysed Diastereoselective Vinylogous Michael Addition Reaction of γ-Substituted Deconjugated Butenolides. J. Org. Chem.2015, 80, 12606–12613.

10. Shi-Xin Nie, Teng-Yu Huang, Hao Guo, Li-Xia Wang, Jie Cui, Jun-Feng Xiang, Yu-Fei Ao, De-Xian Wang, Qi-Qiang Wang* Xenon induces its own preferred heterochiral host from exclusive homochiral assembly. J. Am. Chem. Soc. 2022, 144, 22884-22889.

11. Tiejun Li, Hao Guo, Yuan Wang, Guanghui Ouyang,* Qi-Qiang Wang, Minghua Liu* Chiral macrocycle-induced circularly polarized luminescence of a twisted intramolecular charge transfer dye. Chem. Commun. 2021, 57, 13554-13557.

12. Lin He,* Hao Guo, Yuan-Zhen Li, Guang-Fen Du and Bin Dai* N-Heterocyclic Carbene-catalyzed formal cross-coupling reaction of α-haloenals with thiols: organocatalytic construction of sp² carbon-sulfur bonds.Chem. Commun.2014, 50, 3719-3721.

13. Hao Guo, Ying Wang, Guang-Fen Du,* Mei Xue, Bin Dai* and Lin He* N-Heterocyclic carbene-catalysed amidation of vinyl esters with amines. Tetrahedron2015, 71, 3472–3477.

14. Lin He,* Hao Guo, Ying Wang, Guang-Fen Du, Bin Dai* N-Heterocyclic carbene-mediated transformations of silicon reagents. Tetrahedron Lett. 2015, 56, 972–980.

15. Lin He,* Hao Guo, Xiao-Wei Ma, Jie Zhang, Cheng-Zhi Gu, Wei Wang, Bin Dai*. N-Heterocyclic carbene-catalyzed synthesis of acetyltributylcitrate via a transesterification reaction. Chin. Chem. Lett. 2014, 25, 215–217.