聚焦纳米医药技术创新，围绕重大疾病治疗与绿色农业发展需求，建立跨学科研究体系：

1. 阿尔茨海默症多靶点治疗：基于疾病病理机制设计多功能纳米载药系统，突破血脑屏障限制，实现β-淀粉样蛋白清除、神经元保护与突触功能修复的协同干预，发现具有临床转化潜力的候选纳米药物体系；

2. 耐药菌感染智能治疗：针对细菌生物膜屏障与免疫抑制微环境，开发仿生响应型纳米载药平台，通过精准药物释放与微环境重编程实现高效抗菌，系统阐释其不易诱发耐药性的作用机制；

3. 农业纳米技术革新：创制病原菌微环境响应型纳米农药体系，突破传统农用化学品效率瓶颈，建立植物病害防治新方法，推动农业可持续发展。

科研项目与成果
主持国家级/省部级项目20项（含国家自然科学基金6项、广东省重点研发计划4项），获授权中国发明专利16项，核心技术涵盖神经疾病治疗、抗菌系统构建、肿瘤纳米药物开发及农业纳米制剂等领域。

1998.06，获得博士学位，东北师范大学，导师：王恩波教授；

1998.10 至 2000.09，中山大学博士后，导师：计亮年院士；

2000.09至2007.10，中山大学，副教授，博士生导师；

2007.11 至今，暨南大学，化学与材料学院，教授，博士生导师。

2000.09至2007.10，中山大学，副教授，博士生导师；

2007.11 至今，暨南大学，化学与材料学院，教授，博士生导师。

代表作论文：

1.     Xu Chen,Yonglan Yang, Qiongmei Mai,Gang Ye^*, Yanan Liu,^*Jie Liu^* , Pillar arene Se nanozyme therapeutic systems with dual drive powereffectively penetrated mucus layer combined therapy acute lung injury. Biomaterials,2024,304,122384.

2. Yutong Chen, Ji-an Wei, Liqiang Wang, Qianyu Cai, Fang Yang, Li Zhang*, Jie Liu,* Yanan Liu*, Multi-Enzyme Co-Expressed Ruthenium dioxide nanoparticles activate mitochondrial autophagy and regulate oxidative stress for Alzheimer’s disease treatment. Chemical Engineering Journal,2024,492,151868，

3.Shuhao Lu, Bin Liang , Jianglong Hu, Yanan Liu,*, Fang Yang ,* Jie Liu,*Multidimensional response of dopamine nano-system for on-demandfungicides delivery: Reduced toxicity and synergistic antibacterial effects, Chemical Engineering Journal,2024,482,148990

4. Xiaoyu Yuan, Jieqiong Cen, Xu Chen, Zhi Jia, Xufeng Zhu, Yuqin Huang, Guanglong Yuan, Jie Liu*. Iridium oxide nanoparticles mediated enhanced photodynamic therapy combined with photothermal therapy in the treatment of breast cancer. Journal of Colloid and Interface Science. 2022, 605, 851-862

5. Xu Chen, Zhi Jia, Yayu Wen, Yuqin Huang, Xiaoyu Yuan, Yutong Chen, Jie Liu*. Bidirectional anisotropic palladium nanozymes reprogram macrophages to enhance collaborative chemodynamic therapy of colorectal cancer. Acta biomaterialia 2022, 151, 537-548.

6.Xufeng Zhu, Jiaqi Guo, Yonglan Yang, and Jie Liu.Macrophage Polarization Induced by Bacteria-Responsive Antibiotic-Loaded Nanozymes for Multidrug ResistanceBacterial Infections Management. Small 2022, 2204928

7.Xufeng Zhu,  Youcong Gong,  Yanan Liu,  Chunhua Yang,  Sijie Wu,  Guanglong Yuan,  Xian Guo, Jie Liu∗, Xiuying Qin. Ru@CeO₂ yolk shell nanozymes: Oxygen supply in situ enhanced dual chemotherapy combined with photothermal therapy for orthotopic/subcutaneous colorectal cancer.Biomaterials，2020,242,119922- 119923.

8. ChunfangWei,YananLiu, XufengZhu, XuChen, YanhuiZhou, GuanglongYuan, YoucongGong,       JieLiu,*Iridium/ruthenium nanozyme reactors with cascade catalytic ability for synergistic oxidation therapy and starvation therapy in the treatment of breast cancer. Biomaterials, 2020, 238,119848. 

9.Hui Zhou,Youcong Gong, Yanan Liu, Anlian Huang, Xufeng Zhu, Jiawei Liu, Guanglong Yuan, Li Zhang, Ji-an Wei, Jie Liu* Intelligently thermoresponsive flower-like hollow nano-ruthenium system for sustained release of nerve growth factor to inhibit hyperphosphorylation of tau and neuronal damage for the treatment of Alzheimer's disease. Biomaterials,2020, 237, 119822

 10. Jing Sun, Chunfang Wei, Yanan Liu∗, Wenjie Xie, Mengmeng Xu, Hui Zhou, Jie Liu∗. Progressive release of mesoporous nano-selenium delivery system for the multi-channel synergistic treatment of Alzheimer's disease, Biomaterials 2019,197,417-431.

11. Ange Lin, Yanan Liu, Xufeng Zhu, Xu Chen,  Jiawei Liu, Yanhui Zhou, Xiuying Qin, and Jie Liu*.Bacteria-Responsive Biomimetic Selenium Nanosystem for Multidrug-Resistant Bacterial Infection Detection and Inhibition.ACS Nano 2019, 13, 13965-13984.

2024年发表的论文

1.     Xu Chen,Yonglan Yang, Qiongmei Mai,Gang Ye^*, Yanan Liu,^*Jie Liu^* , Pillar arene Se nanozyme therapeutic systems with dual drive powereffectively penetrated mucus layer combined therapy acute lung injury. Biomaterials,2024,304,122384.

2. Yutong Chen, Ji-an Wei, Liqiang Wang, Qianyu Cai, Fang Yang, Li Zhang^b*, Jie Liu^a,* Yanan Liu*, Multi-Enzyme Co-Expressed Ruthenium dioxide nanoparticles activate mitochondrial autophagy and regulate oxidative stress for Alzheimer’s disease treatment. Chemical Engineering Journal,2024,492,151868.

3.Shuhao Lu^a, Bin Liang ^a, Jianglong Hu ^a, Yanan Liu^b,*, Fang Yang ^a,* Jie Liu^a,*Multidimensional response of dopamine nano-system for on-demandfungicides delivery: Reduced toxicity and synergistic antibacterial effects, Chemical Engineering Journal,2024,482,148990.

4. Bin Liang, Shuhao Lu,Jianglong Hu, Jie Liu*, Yanan Liu*,Green Nanopesticide: pH Response and Molybdenum SelenideCarrier with Photothermal Effect to Transport Prochloraz to InhibitSclerotinia Disease, ACS Applid Materials Interfaces. 2024,16,15931-15945，

5. Xian Guo, Borui Zhang, Yutong Chen, Zhi Jia, Xiaoyu Yuan, Li Zhang,*,Jie Liu*, Yanan Liu*，Multifunctional mesoporous nanoselenium delivery of metformin breaksthe vicious cycle of neuroinflammation and ROS, promotes microgliaregulation and alleviates Alzheimer’s disease. Colloids and Surfaces B: Biointerfaces,2025, 245, 114300，

6. Liqiang Wang, Xiaoyu Yuan, Qianyu Cai, Yutong Chen, Zhi Jia, Qiongmei Mai, Jie Liu,*, Yanan Liu*,Mitochondria-targeting Cu2-xSe-TPP with dual enzyme activity alleviatesAlzheimer’s disease by modulating oxidative stress,Colloids and Surfaces B: Biointerfaces,2025,245,114244

7. Yonglan Yang^a, Qianyu Cai^a, Liqiang Wang^b, Qiongmei Mai^b, Gang Ye^b, Jie Liu^b,*,Yanan Liu ^a,*Oxygen-Deficient Bi₂MoO₆@sRuO₂@HA heterojunction for photocatalytictreatment of drug-resistant bacterial infections, Chemical Engineering Journal, 2024,502,157828.

8.Qiongmei Mai, Yu Lu, Qianyu Cai, Jianglong Hu, Yunyou Lv, Yonglan Yang, Liqiang Wang, Yuezhao Zhouand Jie Liu*, pH and Pectinase Dual-Responsive Zinc Oxide Core-Shell Nanopesticide: Efficient Control of Sclerotinia Disease andReduction of Environmental Risks,Nanomaterials 2024, 14, 2022.

2023年发表的论文

1.     Xiaoyu Yuan, Ran Tang, Jia, Zhi, Yutong Chen, Jie Liu^*, Yanan Liu^*, Zn²⁺-responsive palladium nanoclusters synergistically manage Alzheimer’s disease through neuroprotection and inhibition of oxidative stress. Chemical Engineering Journal, 2023, 464.

2.     Zhi Jia, Ran Tang, Xiaoyu Yuan, Hengmin Zhu, Jiaqi Guo, Yutong Chen, Yonglan Yang,

Bin Liang, Shuhao Lu, Derong Cao, and Jie Liu^*, Multifunctional Supramolecular Vesicles as Zn(2+) -Triggered Microglial Modulator Alleviates Alzheimer's Disease. Small 2023, e2302176.

3.     Xu Chen, Yonglan Yang, Gang Ye^*, Shengming Liu^*, Jie Liu^*, Chiral Ruthenium Nanozymes with Self-Cascade Reaction Driven the NO Generation Induced Macrophage M1 Polarization Realizing the Lung Cancer Cocktail Therapy. Small 2023, e2207823.

4.     Yuqin Huang, Yonglan Yang, Bin Liang, Shuhao Lu, Xiaoyu Yuan, Zhi Jia, Jie Liu^*, and Yanan Liu^*, Green Nanopesticide: pH-Responsive Eco-Friendly Pillar[5]arene-Modified Selenium Nanoparticles for Smart Delivery of Carbendazim to Suppress Sclerotinia Diseases. ACS Applied Materials & Interfaces, 2023, 15, 16448-16459.

5.  Xufeng Zhu,^a,b,c Yonglan Yang,^b Xu Chen,^b Gang Ye,^*b Jie Liu ^*b and Yanan Liu^*a，Ir(IV) and Ir(III) in situ transition promotes ROS generation for eradicating multidrug-resistant bacterial infection，Biomaterials Science，2023, 11, 4960-4971  

6.  Yanan Liu^a*, Guanglong Yuan^b, Xu Chen^b,c*, Jie Liu^b*, Near infrared band responsive ROS regulator selectively inhibits breast cancer cells by programming combination phototherapy,Journal of Materials Chemistry B, 2023,11,1356

7.  7. Licong Yang^ab, Yutong Chen^a, Zhi Jia^a, Xiaoyu Yuan^a, Jie Liu^*a, Electrostatic assembly of gold nanoparticle and metal-organic framework nanoparticles attenuates amyloid beta aggregate-mediated neurotoxicity. Journal of Materials Chemistry B, 2023, 11, 4453-4463.

8.  Jiaqi Guo, Xinyi Zhang, Yonglan Yang, Xufeng Zhu, Xu Chen, Gang Ye* and Jie Liu *, Reactive oxygen species-mediated CuRuOX@HA hybrid nanozymes for multidrug-resistant bacterial infections with synergistic photothermal therapy, Journal of Materials Chemistry B, 2023, 11, 5195–5206.

9.  Yanan Liu^*,Yutong Chen, Youcong Gong, Huawen Yang^*, Jie Liu^*, Polydopamine/Ruthenium Nanoparticle Systems as Photothermal Therapy Reagents and Reactive Oxygen Species Scavengers for Alzheimer’s Disease Treatment. ACS Appl. Nano Mater. 2023, 6, 5384-5393.

10.   Yonglan Yang, Jieqiong Cen, Jie Liu,^* andYanan Liu^*，Iridium Oxide-Doped Calcium Phosphate Nanoparticles for Chemodynamic Therapy of Cancer. ACS Appl. Nano Mater. 2023, 6, 12447-12458.

11. Ran Tang, Xiaoyu Yuan, Zhi Jia, Fang Yang, Gang Ye,* and Jie Liu*. Ruthenium Dioxide Nanoparticles Treat Alzheimer’s Disease by Inhibiting Oxidative Stress and Alleviating Neuroinflammation. ACS Appl. Nano Mater. 2023, 6, 11661−11678

12.Yanan Liu^*, Chuping Zheng, Jie Liu^*. Effect of size and morphology of functionalized upconversion nanaoparticle labeled probe on stem cell absorption. Journal of Biomaterials Applications，2023, 37(10) 1823–1834.

13. Qianyu Cai ^a, Xian Guo ^a, Yutong Chen ^b, Jie Liu ^b *, and Yanan Liu ^a*，Selenium-Doped 3D Porous Molybdenum Carbide Nanospheres Improve Mitochondrial Function by Reducing Oxidative Stress in Alzheimer’s Disease，ACS Applied Nano Materials，2023，6,22496-22505

2022年

1. Xiaoyu Yuan, Jieqiong Cen, Xu Chen, Zhi Jia, Xufeng Zhu, Yuqin Huang, Guanglong Yuan, Jie Liu*. Iridium oxide nanoparticles mediated enhanced photodynamic therapy combined with photothermal therapy in the treatment of breast cancer. Journal of Colloid and Interface Science. 2022, 605, 851-862.

2. Xu Chen, Zhi Jia, Yayu Wen, Yuqin Huang, Xiaoyu Yuan, Yutong Chen, Jie Liu*. Bidirectional anisotropic palladium nanozymes reprogram macrophages to enhance collaborative chemodynamic therapy of colorectal cancer. Acta biomaterialia 2022, 151, 537-548.

3.Qianqian Yu, Yuqin Huang, Xu Chen, Yutong Chen, Xufeng Zhu, Yanan Liu, Jie Liu*. A neutrophil cell membrane-biomimetic nanoplatform based on L-arginine nanoparticles for early osteoarthritis diagnosis and nitric oxide therapy.Nanoscale 2022, 14,11619. 

4. Yanan Liu, Yuqin Huang, Jiawei Liu, Jie Liu*. A temperature-responsive selenium nanohydrogel for strawberry grey mould management.Journal of Materials Chemistry B，2022, 10, 5231.

5.Yanan Liu, Junfang Huang, Jie Liu*. Single laser activated photothermal/photodynamic dual-modal cancer phototherapy by using ROS-responsive targeting flower-like ruthenium nanoparticles. Journal of Materials Chemistry B 2022,10, 7760.

6.Jieqiong Cen,‡^ab Yuqin Huang,‡^ab Jie Liu *^b and Yanan Liu*^a. Thermo-responsive palladium–ruthenium nanozyme synergistic photodynamic therapy for metastatic breast cancer management. Journal of Materials Chemistry B, 2022,10,10027-10041.

7.Xufeng Zhu, Jiaqi Guo, Yonglan Yang, and Jie Liu*. Macrophage Polarization Induced by Bacteria-Responsive Antibiotic-Loaded Nanozymes for Multidrug ResistanceBacterial Infections Management. Small 2022, 2204928.

2021年

1. Youcong Gong, Anlian Huang, Xian Guo, Zhi Jia, Xu Chen, Xufeng Zhu, Yu Xia*, Jie Liu*, Ying Xu, Xiuying Qin. Selenium-core nanozymes dynamically regulates Aβ & neuroinflammation circulation: Augmenting repair of nervous damage. Chemical Engineering Journal. 2021, 418,129345.

2. Xu Chen, Xufeng Zhu, Youcong Gong, Guanglong Yuan, Jieqiong Cen, Qiaoshan Lie, Yida Hou, Gang Ye, Shengming Liu∗，Jie Liu∗. Porous selenium nanozymes targeted scavenging ROS synchronize therapy local inflammation and sepsis injury, Applied Materials Today, 2021, 22,100929.

3. Xufeng Zhu, Xu Chen, Zhi Jia, Dongliang Huo, Yanan Liu, Jie Liu∗，Cationic chitosan Ruthenium dioxide hybrid nanozymes for photothermal therapy enhancing ROS-mediated eradicating multidrug resistant bacterial infection，Journal of Colloid and Interface Science. 2021, 603,615-632.

4. Xufeng Zhu, Xu Chen, Dongliang Huo, Jieqiong Cen, Zhi Jia, Yanan Liu*, and Jie Liu*, A hybrid nanozymes in situ oxygen supply synergistic photothermal/chemotherapy of cancer management. Biomater. Sci., 2021, 9, 5330-5343.

5. Xian Guo, Qiaoshan Lie, Yanan Liu, Zhi Jia, Youcong Gong, Xiaoyu Yuan, and Jie Liu*. Multifunctional Selenium Quantum Dots for the Treatment of Alzheimer’s Disease by Reducing Aβ-Neurotoxicity and Oxidative Stress and Alleviate Neuroinflammation. ACS Appl. Mater. Interfaces 2021, 13, 30261-30273.

6. Yanan Liu, Guanglong Yuan, Hairong Nan, Jieqiong Cen, Xufeng Zhu, Yanhui Zhou,  Jie Liu*.  Selenium nanoparticles with various morphology for antiangiogenesis through bFGF-mediated P13K/AKT signaling pathways, Nanotechnology, 2021, 32, 485102

7. Guanglong Yuan, Jieqiong Cen, Jiamin Liao, Yuqin Huang and Liu Jie*. In situ hydrogen nanogenerator for bimodal imaging guided synergistic photothermal/hydrogen therapies,

Nanoscale, 2021,13,15576-15589. 

8. Xiaoyu Yuan,Zhi Jia,Jin Li,*Yanan Liu,Yuqin Huang,Youcong Gong,Xian Guo,Xu Chen,Jieqiong Cenand Jie Liu*. A diselenide bond-containing ROS-responsive ruthenium nanoplatform delivers nerve growth factor for Alzheimer’s disease management by repairing and promoting neuron regeneration. Journal of Materials Chemistry B，2021, 9, 7835–7847.

2021, 9, 7835-7847

9. Yanan Liu, Dongliang Huo, Xufeng Zhu,b Xu Chen, Ange Lin, Zhi Jia and Jie Liu*. A ruthenium nanoframe/enzyme composite system as a self-activating cascade agent for the treatment of bacterial infections. Nanoscale. 2021, 13, 14900-14914. 

10.Zhi Jia, Xiaoyu Yuan, Ji-an Wei, Xian Guo, Youcong Gong, Jin Li, Hui Zhou, Li Zhang,* and Jie Liu*. A Functionalized Octahedral Palladium Nanozyme as a Radical Scavenger for Ameliorating Alzheimer’s Disease. ACS Appl. Mater. Interfaces. 2021, 13, 49602-49613.

11.Yanan Liu, Jiawei Liu, Xiaoping Guo, Ange Lin, Yayu Wen, Xu Chen, Xufeng Zhu, Jie Liu, Zhaohui Luo, Photosensitive properties, synergistic antibacterial abilities of intelligent response-type self-assembled nanoparticle TiO₂@V₂O₅. Journal of Biomaterials Applications, 2021, 35(6), 696-708.

2020年论文：

1. Jiawei Liu, Xufeng Zhu,Xu Chen, Yanan Liu, Youcong Gong, Guanglong Yuan, Jie Liu* and Lanmei Chen.  Defense and inhibition integrated mesoporousnanoselenium delivery system against tomato gray mold，Environ. Sci.Nano, 2020, 7, 210-227.

2. Xufeng Zhu,  Youcong Gong,  Yanan Liu,  Chunhua Yang,  Sijie Wu,  Guanglong Yuan,  Xian Guo, Jie Liu∗, Xiuying Qin. Ru@CeO₂ yolk shell nanozymes: Oxygen supply in situ enhanced dual chemotherapy combined with photothermal therapy for orthotopic/subcutaneous colorectal cancer.Biomaterials，2020,242,119922- 119923.

3.ChunfangWei,YananLiu, XufengZhu, XuChen, YanhuiZhou, GuanglongYuan, YoucongGong, JieLiu,*Iridium/ruthenium nanozyme reactors with cascade catalytic ability for synergistic oxidation therapy and starvation therapy in the treatment of breast cancer. Biomaterials, 2020, 238,119848.

4.Hui Zhou,Youcong Gong, Yanan Liu, Anlian Huang, Xufeng Zhu, Jiawei Liu, Guanglong Yuan, Li Zhang, Ji-an Wei, Jie Liu* Intelligently thermoresponsive flower-like hollow nano-ruthenium system for sustained release of nerve growth factor to inhibit hyperphosphorylation of tau and neuronal damage for the treatment of Alzheimer's disease. Biomaterials,2020, 237, 119822,

5.Yanan Liu, Youcong Gong, Wenjie Xie, Anlian Huang, Xiaoyu Yuan, Hui Zhou, Xufeng Zhu, Xu Chen, Jiawei Liu, Jie Liu*, and Xiuying Qin*. Microbubbles in combination with focused ultrasound for the delivery of quercetin-modified sulfur nanoparticles through the blood brain barrier into the brain parenchyma and relief of endoplasmic reticulum stress to treat Alzheimer’s disease. Nanoscale, 2020, 12, 6498- 6511.

6. Xufeng Zhu, Yanan Liu, Guanglong Yuan, Xian Guo, Jieqiong Cen, Youcong Gong, Jie Liu* and Ye Gang*. In situ fabrication of MS@MnO₂ hybrid as nanozymes for enhancing ROS-mediated breast cancer therapy. Nanoscale, 2020, 12, 22317，

7.Yanan Liu, Chunfang Wei, Ange Lin, Jiali Pan, Xu Chen, Xufeng Zhu,Youcong Gong, Guanglong Yuan, Lanmei Chen, Jie Liu^*, Zhaohui Luo,*Responsive functionalized MoSe₂ nanosystem for highly efficient synergistictherapy of breast cancer. Colloids and Surfaces B: Biointerfaces 189 (2020) 110820.