个人信息

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姓名: 张欢

部门: 化学与材料学院化学系

直属机构: 化学与材料学院

性别:

职务:

职称: 教授

学位: 博士

毕业院校: 中国科学院大学

联系电话: 15502160026

电子邮箱: huanzhang@jnu.edu.cn

办公地址: 广东省广州市番禺区兴业大道东855号

通讯地址:

邮编: 511443

传真:

荣誉奖励:

联系方式

Email: huanzhang@jnu.edu.cn; huanzh16@gmail.com


个人简介

自博士以来一直致力于纳米材料的可控设计、合成、修饰以及后续生物学应用研究,利用石墨烯、纳米金、DNA纳米结构进行了系列研究及应用探索,已在Proceedings of the National Academy of Sciences PNAS)、Nature CommunicationsNature ProtocolsNature NanotechnologyNanoscaleACS Applied Materials & InterfacesBiosensors and BioelectronicsSensors and Actuators B: Chemical、Analytical Chemistry等国际高水平杂志发表论文17篇,其中12篇一作文章(包含共同一作),总引用次数800余次,i10-index达到16(Google Scholar),参与编写英文专著一章。研究成果得到学术界及工业界的广泛报道及关注,并且得到产业转化资助。应邀参加25th International Conference on DNA Computing and Molecular Programming (DNA25)、ACS Nano等国际会议并作报告,热烈欢迎化学、材料学、生物学及交叉科学的研究生、博后加入课题组!


学习经历

20099月—20147月 中国科学院大学,上海应用物理研究所 博士(导师:樊春海院士)

20059月—20097月 鲁东大学 学士


工作经历

20209月至今 暨南大学化学与材料学院 教授;

20172月—20207月 加州大学伯克利分校 博后(合作导师:Markita P. Landry);

20149月—20171月 中国科学院上海高等研究院 助理研究员。


研究方向

1, 生物相容性纳米材料的功能化修饰;

2DNA折纸纳米结构的设计、组装及其应用研究(检测、成像、药物递送等);

3,基于CRISPR/Cas系统的纳米机器的设计及诊疗应用。


主要论文

1, Huan Zhang#, Honglu Zhang#, Gozde S. Demirer, Eduardo González-Grandío, Chunhai Fan and Markita P. Landry. Engineering DNA nanostructures for siRNA delivery in plants. Nature Protocols, 2020,15, 3064–3087.

2, Huan Zhang#*, Xinxin Liu#, Chunxiu Zhang, Yi Xu, Jing Su, Xiaoliang Lu, Jiye Shi, Lihua Wang, Markita P. Landry, Ying Zhu, Min Lv*, Xianqiang Mi*. A DNA tetrahedral structure-mediated ultrasensitive fluorescent microarray platform for nucleic acid test. Sensors & Actuators: B. Chemical, 2020, 321, 12853.

3, Huan Zhang#, Gozde S. Demirer#, Honglu Zhang#, Tianzheng Ye, Natalie S. Goh, Abhishek J. Aditham, Francis J. Cunningham, Chunhai Fan and Markita P. Landry*. Low-dimensional DNA Nanostructures Coordinate Gene Silencing in Mature Plants. PNAS, 2019, 116, 7543-7548

4, Gozde S. Demirer#, Huan Zhang# (co-first author), Natalie S. Goh, Eduardo González-Grandío and Markita P. Landry*. Carbon nanotube–mediated DNA delivery without transgene integration in intact plants. Nature Protocols, 2019,14, 2954–2971.

5, Honglu Zhang#, Yu Wang#, Huan Zhang# (co-first author), Antony Lee, Jie Chao, Huajie Liu, Jiang li, Jiye Shi, Lihua Wang, Lianhui Wang, Xiaoyu Cao, Carlos Bustamante, Zhongqun Tian*, Chunhai Fan*. Programming chain-growth co-polymerization of DNA hairpin tiles for in-vitro hierarchical supramolecular organization. Nature Communications, 2019, 10, 1006.

6, Gozde S. Demirer, Huan Zhang, Juliana L. Matos, Natalie Goh, Francis Cunningham, Younghun Sung, Roger Chang, Abhishek J. Aditham, Linda Chio, Myeong-Je Cho, Brian Staskawicz and Markita P. Landry*. High Aspect Ratio Nanomaterials Enable Delivery of Functional Genetic Material Without Transgenic DNA Integration in Mature Plants. Nature Nanotechnology, 2019, 14, 456–464.

7, Lu Wang#, Huan Zhang# (co-first author), Chenguang Wang, Yi Xu, Jing Su, Xiao Wang, Xinxin Liu, Dezhi Feng, Lihua Wang, Xiaolei Zuo, Jiye Shi, Zhilei Ge*, Chunhai Fan, Xianqiang Mi*. Poly-adenine-mediated spherical nucleic acids for strand displacement-based DNA/RNA detection. Biosensors and Bioelectronics, 2019, 127, 85-91.

8, Huan Zhang#, Honglu Zhang#, Ali Aldalbahi, Xiaolei Zuo, Chunhai Fan, Xianqiang Mi*. Fluorescent Biosensors Enabled by Graphene and Graphene Oxide. Biosensors and Bioelectronics, 2017, 89, 96-106.

9,Huan Zhang, Yunsheng Wang, Daiwei Zhao, Dongdong Zeng, Jiaoyun Xia, Ali Aldalbahi, Chenguang Wang, Lili San, Chunhai Fan, Xiaolei Zuo*, and Xianqiang Mi*. Universal Fluorescence Biosensor Platform Based on Graphene Quantum Dots and Pyrene-Functionalized Molecular Beacons for Detection of MicroRNAs. ACS Applied Materials & Interfaces, 2015, 7, 16152-16156.

10,Huan Zhang, Sisi Jia, Min Lv, Jiye Shi, Xiaolei Zuo, Shao Su, Lianhui Wang, Wei Huang, Chunhai Fan, Qing Huang. Size-Dependent Programming of the Dynamic Range of Graphene Oxide–DNA Interaction-Based Ion Sensors. Analytical Chemistry, 2014, 86, 4047-4051.


主要著作

Francis J Cunningham, Gozde S Demirer, Natalie S Goh, Huan Zhang, Markita P Landry. Nanobiolistics: An Emerging Genetic Transformation Approach. Biolistic DNA Delivery in Plants, 2020,141-159.


承担课题

1,暨南大学第四层次人才启动经费,100万元,主持;

2,NSFC青年科学基金:DNA纳米技术调控的新型芯片体系开发及其microRNA检测研究(21605153), 2017.1.1-2019.12.31,20万元,主持。


发明专利

1,一种单层石墨烯的制备方法,张玉杰,张欢,胡文兵,樊春海,黄庆。CN101973543,中国

2,一种纳米金-氧化石墨烯纳米复合材料的制备方法张玉杰,耿马可,张欢,李江,樊春海,黄庆CN101973518,中国。

讲授课程

《高等分析化学》,《现代分析技术》,《分析化学实验》


荣誉奖励

社会职务

期刊杂志审稿,如Nature Communications,ACS Applied Materials & Interfaces,Scientific Reports,Biosensors and BioelectronicsAnalytical Chemistry等。