个人简介
曾珊,医学博士,现为暨南大学附属第一医院风湿科副主任医师,硕士研究生导师,从事风湿病学临床工作及研究,目前在国内外重要刊物发表文章17篇,其中以第一作者、通讯作者发表SCI收录论文13篇,主持包括国家级和省部级课题研究4项。主要研究方向:eEF2K在类风湿关节炎疾病发生发展中的作用机制研究,类风湿关节炎中与T细胞相关的生物标志物研究,类风湿关节炎先天免疫基因的分析及潜在治疗作用,BRD4蛋白调控浆细胞分化及对系统性红斑狼疮的治疗潜力。入选南大学“优秀青年教师”、医院“科研工作先进个人”“医疗护理工作先进个人”等系列称号。
主要论文
Nan Li; Shulin Chen; Weiqing Deng; Zhaohui Gong; Yu Guo; Shan Zeng; Qiang Xu ; Kaempferol Attenuates Gouty Arthritis by Regulating the Balance of Th17/Treg Cells and Secretion of IL-17, Inflammation, 2023, -(5): 1901-1916 Zeng S., Qiu Q., Zhou Y., Xiao Y., Wang J., Li R., Xu S., Shi M., Wang C., Kuang Y., Lao M., Cai X., Liang L., Xu H.; The suppression of Brd4 inhibits peripheral plasma cell differentiation and exhibits therapeutic potential for systemic lupus erythematosus, International Immunopharmacology, 2022, 103 Zhenyu Zhao; Shaojie He; Sheng Tang; Xiaofeng Lai; Jie Ren; XinCheng Yu; Jinhua Lin; Mohan Wang; Mariya M. El Akkawi; Shan Zeng; Dingsheng Zha ; CLP1 is a Prognosis-Related Biomarker and Correlates With Immune Infiltrates in Rheumatoid Arthritis, Frontiers in Pharmacology, 2022, 13 Zhenyu Zhao; Jie Ren; Siping Xie; Longchun Zou; Qianyue Zhao; Shan Zeng; Dingsheng Zha ; Identification of biomarkers associated with CD8+ T cells in rheumatoid arthritis and their pan-cancer analysis, Frontiers in Immunology, 2022, 13 Nan Li, Xiaojuan Li, Lijuan Deng, Haixin Yang, Zhaohui Gong, Qiang Wang, Dongmei Pan, Shan Zeng, Jiaxu Chen; 6-Shogaol inhibits the proliferation, apoptosis, and migration of rheumatoid arthritis fibroblast-like synoviocytes via the PI3K/AKT/NF-κB pathway, Phytomedicine, 2022, 109: 154562 ZhenYu Zhao, ShaoJie He, XinCheng Yu, XiaoFeng Lai, Sheng Tang, El Akkawi Mariya M, MoHan Wang, Hai Yan, XingQi Huang, Shan Zeng, DingSheng Zha; Analysis and Experimental Validation of Rheumatoid Arthritis Innate Immunity Gene CYFIP2 and Pan-Cancer, Frontiers in Immunology, 2022, 13 Huang, Mingcheng; Wu, Keping; Zeng, Shan; Liu, Wenfen; Cui, Tianjiao; Chen, Zhiqing; Lin, Lian; Chen, Dongying; Ouyang, Hui; Punicalagin Inhibited Inflammation and Migration of Fibroblast-Like Synoviocytes Through NF-kappa B Pathway in the Experimental Study of Rheumatoid Arthritis, Journal of Inflammation Research, 2021, 14: 1901-1913 Chen, Dongying; Zeng, Shan; Huang, Mingcheng; Xu, Hanshi; Liang, Liuqin; Yang, Xiuyan ; Role of protein arginine methyltransferase 5(PRMT5) in inflammation and migration of fibroblast-like synoviocytes in rheumatoid arthritis, Journal of Cellular and Molecular Medicine, 2017, 21(4): 781-790 Huang, Mingcheng; Zeng, Shan; Zou, Yaoyao; Shi, Maohua; Qiu, Qian; Xiao, Youjun; Chen, Guoqiang; Yang, Xiuyan; Liang, Liuqin; Xu, Hanshi ; The suppression of bromodomain and extra-terminal domain inhibits vascular inflammation by blocking NF-kappaB and MAPK activation., British Journal of Pharmacology, 2017, 174(1): 101-115 Zeng, Shan; Wang, Kefeng; Huang, Mingcheng; Ou, Qian; Xiao, Youjun; Shi, Maohua; Zou, Yaoyao; Yang, Xiuyan; Xu, Hanshi; Liang, Liuqin ; Halofuginone inhibits TNF-alpha-induced the migration and proliferation of fibroblast-like synoviocytes from rheumatoid arthritis patients, International Immunopharmacology, 2017, 43: 187-194 Huang, Mingcheng; Zeng, Shan; Qiu, Qian; Xiao, Youjun; Shi, Maohua; Zou, Yaoyao; Yang, Xiuyan; Xu, Hanshi; Liang, Liuqin ; Niclosamide induces apoptosis in human rheumatoid arthritis fibroblast-like synoviocytes., International Immunopharmacology, 2016, 31: 45-49 Zou, Yaoyao; Zeng, Shan; Huang, Mingcheng; Qiu, Qian; Xiao, Youjun; Shi, Maohua; Zhan, Zhongping; Liang, Liuqin; Yang, Xiuyan; Xu, Hanshi ; Inhibition of 6-phosphofructo-2-kinase suppresses fibroblast-like synoviocytes-mediated synovial inflammation and joint destruction in rheumatoid arthritis, British Journal of Pharmacology, 2017, 174(9): 893-908
承担课题
1、EphA4对 RhoA/Rac1/Cdc42通路介导的类风湿关节炎成纤维样滑膜细胞迁移和侵袭的调控,国家自然科学基金委员会-青年科学基金项目结题, 主持 2、基于外泌体miR-1246介导SDF-1/CXCR4信号通路探讨 桂枝芍药知母汤调控RA软骨基质代谢平衡的作用机制,国家自然科学基金委员会-面上项目,在研, 参与 3、EphA4对糖酵解关键酶PKM2介导的类风湿关节炎成纤维样滑膜细胞葡萄糖重编程及迁移、侵袭的调控,广州市科学技术局, 广州市科技计划项目基础与应用基础研究项目(市校联合),在研, 主持 4、eEF2K对类风湿关节炎成纤维样滑膜细胞异常活化及侵袭的调控作用及其机制研究,广州市科学技术局-广州市基础研究计划基础与应用基础研究项目,结题, 主持
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