刘璠娜，女，博士，主任医师，博士生导师，博士后合作导师，现任暨南大学附属第一医院肾内科主任。  

主持及参与国家及省部级课题10余项，包括广州市科技计划项目、广东省中医药局项目、广东省卫计委适宜技术推广项目等，研究方向涵盖血液净化技术创新、慢性肾脏病诊疗体系优化、糖尿病肾病机制研究等。    

  以第一作者或通讯作者发表SCI论文30余篇，发表于《Chemical Engineering Journal》《Frontiers in Immunology》《Scientific Reports》等国际权威期刊，聚焦肾脏病临床诊疗、人工智能辅助医疗技术、代谢组学与免疫调控等前沿领域。   

参编专著：《糖尿病肾病》（人民卫生出版社）、《血液净化学》（北京科学技术出版社）等4部专著。  

授权专利：获国家发明专利3项，推动血液净化技术智能化发展。  

刘璠娜博士深耕肾脏病临床与科研二十余年，在血液净化技术革新、慢性肾脏病一体化治疗、糖尿病肾病机制研究等领域取得突出成果，同时致力于医学教育与社会服务。

（1）2005-09至2008-07,暨南大学,生物医学工程,博士

（2）2002-09至2005-07,暨南大学,肾内科,硕士

（3）2000-09至2002-07,西安交通大学医学院,临床医学,学士

（4）1996-09至1999-07,长治医学院,临床医学,其他

(1)2019-10至今,暨南大学医学部/第一临床医学院,肾内科,主任医师

(2)2014-10至2019-09,暨南大学医学部/第一临床医学院,肾内科,副主任医师

(3)2009-06至2014-09,暨南大学医学部/第一临床医学院,肾内科,主治医师

(4)2013-07至2014-06,美国克里夫兰医学中心,肾脏病与高血压中心,主治医师

(5)2008-07至2009-05,暨南大学医学部/第一临床医学院,肾内科,医师

（1）Ai赋能慢性肾脏病医防融合及一体化治疗

（2）糖尿病肾脏病、IgA肾病等原发性及继发性肾脏病的机制研究

（3）血液净化新技术及新产品开发

1、Xing Zhang, Ye Hu, Haofei Li, Junlin Chen, Chuhan Lv, Xiaobao Yang, Fanna Liu, Xin Chen, Hua Dong,Artificial intelligence-assisted wearable porous eutectogel with high-performance NH3 enrichment and visual sensing enables non-invasive monitoring of chronic kidney disease,Chemical Engineering Journal,Volume 507,2025,160678,ISSN 1385-8947,Volume 507, 1 March 2025, 160678

2、Yang CC, Chen KH, Yue Y, Cheng BC, Hsu TW, Chiang JY, Chen CH, Liu F, Xiao J, Yip HK. SGLT2 inhibitor downregulated oxidative stress via activating AMPK pathway for cardiorenal (CR) protection in CR syndrome rodent fed with high protein diet. J Mol Histol. 2024 Oct;55(5):803-823.

3、Yang Z, Chen L, Huang Y, Dong J, Yan Q, Li Y, Qiu J, Li H, Zhao D, Liu F, Tang D, Dai Y. Proteomic profiling of laser capture microdissection kidneys from diabetic nephropathy patients. J Chromatogr B Analyt Technol Biomed Life Sci.2024 Aug 1;1243:124231.

4、Kuang C, Shang J, Ma M, Huang S, Yan B, Zhong Y, Guan B, Gong J, Liu F, Chen L. Risk factors and clinical prediction models for osteoporosis in pre-dialysis chronic kidney disease patients. Ren Fail. 2024 Dec;46(2):2361802.

5、Liu S, Qiu C, Li W, Li X, Liu F, Hu G. Blood urea nitrogen to serum albumin ratio as a new prognostic indicator in type 2 diabetes mellitus patients with chronic kidney disease. Sci Rep. 2024 Apr 5;14(1):8002.

6、Yang Y, Liang W, Gong W, Li S, Chen S, Yang Z, Kuang C, Zhong Y, Yang D, Liu F. Establishment and evaluation of a nomogram prediction model for the risk of vascular calcification in stage 5 chronic kidney disease patients. Sci Rep. 2024 Jan 10;14(1):1025.

7、 Lin M, Zhong Y, Zhou D, Guan B, Hu B, Wang P, Liu F. Proximal tubule cells in blood and urine as potential biomarkers for kidney disease biopsy. PeerJ. 2023 Dec 6;11:e16499. 

8、Kuang C, Li D, Zhou X, Lin H, Zhang R, Xu H, Huang S, Tang F, Liu F, Tang D, Dai Y. Proteomic analysis of lysine 2-hydroxyisobutyryl in SLE reveals protein modification alteration in complement and coagulation cascades and platelet activation Pathways. BMC Med Genomics. 2023 Oct 16;16(1):247.

9、Li S, Zhang Y, Yang Y, Chen S, Yang Z, Kuang C, Zhong Y, Liu F. The impact of statin use before intensive care unit admission on patients with acute kidney injury after cardiac surgery. Front Pharmacol. 2023 Sep 14;14:1259828.

10、 Chen S, Li D, Zeng Z, Zhang W, Xie H, Tang J, Liao S, Cai W, Liu F, Tang D,Dai Y. Analysis of proteome and post-translational modifications of 2-hydroxyisobutyrylation reveals the glycolysis pathway in oral adenoid cystic carcinoma. World J Surg Oncol. 2023 Sep 23;21(1):301.

11、 Liu S, Zhong Z, Liu F. Prognostic value of hyperuricemia for patients with sepsis in the intensive care unit. Sci Rep. 2022 Jan 20;12(1):1070.

12、 Qiu C, Liu S, Li X, Li W, Hu G, Liu F. Prognostic value of monocyte-to-lymphocyte ratio for 90-day all-cause mortality in type 2 diabetes mellitus patients with chronic kidney disease. Sci Rep. 2023 Aug 12;13(1):13136.

13、Chen S, Li S, Kuang C, Zhong Y, Yang Z, Yang Y, Liu F. Aspirin reduces the mortality risk of sepsis-associated acute kidney injury: an observational study using the MIMIC IV database. Front Pharmacol. 2023 Jul 25;14:1186384.

14、Yang Y, Ma C, Li S, Cai W, Dai W, Zhang X, Yin L, Donge Tang, Liu F, Dai Y. Urinary microbiota and serum metabolite analysis in patients with diabetic kidney disease. Heliyon. 2023 Jul 3;9(8):e17040.

15、Yang Z, Zhang W, Li L, Hu N, Dong X, Chen Y, Cai W, Yin L, Liu F, Tang D, Dai Y. The novel putative methyltransferase METTL7A as one prognostic biomarker potentially associated with immune infiltration in human renal cancer. Heliyon. 2023 Apr 11;9(4):e15371.  

16、Liu S, Qiu C, Li X, Yu Z, Liu F, Hu G. A nomogram for predicting the mortality of patients with type 2 diabetes mellitus complicated with acute kidney injury in the intensive care unit. BMC Anesthesiol. 2023 Jan 4;23(1):4.

17、Li S, Ma C, Yang Y, Cai W, Dai W, Zhang X, Yin L, Tang D, Liu F, Dai Y. Microbiome and metabolome analysis to clarify the interaction between the urine microbiota and serum metabolites in Chinese patients with immunoglobulin A nephropathy. Ann Transl Med. 2022 Nov;10(22):1230. 

18、Gao M, Zhong Z, Yue Y, Liu F. Correlation between glycaemic variability and prognosis in diabetic patients with CKD. Endokrynol Pol. 2022;73(6):947-953. 

19、Zhang W, Yang Y, Lin L, He J, Dong J, Yan B, Cai W, Chen Y, Yin L, Tang D, Liu F, Dai Y. Comprehensive characterization of ubiquitinome of human colorectal cancer and identification of potential survival-related ubiquitination. J Transl Med. 2022 Oct 2;20(1):445.

20、 Wu H, Liu F, Shangguan Y, Yang Y, Shi W, Hu W, Zeng Z, Hu N, Zhang X, Hocher B, Tang D, Yin L, Dai Y. Correction to: Integrating spatial transcriptomics with single-cell transcriptomics reveals a spatiotemporal gene landscape of the human developing kidney. Cell Biosci. 2022 Sep 25;12(1):161.

21、Wu H, Dong J, Yu H, Wang K, Dai W, Zhang X, Hu N, Yin L, Tang D, Liu F, Dai Y. Single-Cell RNA and ATAC Sequencing Reveal Hemodialysis-Related Immune Dysregulation of Circulating Immune Cell Subpopulations. Front Immunol. 2022 May 26;13:878226.

22、Yu H, Lian M, Li J, Huang J, Zhang Y, Liu F. Effects of nursing intervention based on feedforward control on preventing unplanned interruption during continuous renal replacement therapy. Minerva Surg. 2023 Aug;78(4):462.

23、Wu H, Liu F, Shangguan Y, Yang Y, Shi W, Hu W, Zeng Z, Hu N, Zhang X, Hocher B, Tang D, Yin L, Dai Y. Integrating spatial transcriptomics with single-cell transcriptomics reveals a spatiotemporal gene landscape of the human developing kidney. Cell Biosci. 2022 Jun 3;12(1):80.  

24、Yue Y, Yeh JN, Chiang JY, Sung PH, Chen YL, Liu F, Yip HK. Intrarenal arterial administration of human umbilical cord-derived mesenchymal stem cells effectively preserved the residual renal function of diabetic kidney disease in rat. Stem Cell Res Ther. 2022 May 7;13(1):186.

25、 Yu Z, Hong X, Zhang X, Zheng F, Liu F, Xu H, Zhu C, Cai W, Liu D, Yin L, Hu B, Tang D, Dai Y. Global Proteomic Analyses Reveals Abnormal Immune Regulation in Patients With New Onset Ankylosing Spondylitis. Front Immunol. 2022 Mar 17;13:838891.

26、Gong W, Yao L, Zhong X, Qin D, Huang C, Yin L, Liu F. Prevalence and associated factors of frailty among Southern Chinese Han patients on haemodialysis: a multicentre, observational cross-sectional study. BMJ Open. 2022 Mar 16;12(3):e054177.

27、Wu H, Tang D, Yun M, Liu H, Huang S, Yun C, Hocher B, Zhang X, Liu F, Yin L, Dai Y. Metabolic Dysfunctions of Intestinal Fatty Acids and Tryptophan RevealImmuno-Inflammatory Response Activation in IgA Nephropathy. Front Med(Lausanne). 2022 Feb 3;9:811526.

28、Huang Yingxin; Zhong Zhihua; Liu Fanna. The Association of Coagulation Indicators and Coagulant Agents With 30-Day Mortality of Critical Diabetics. Clin Appl Thromb Hemost, 2021, 27: 1-8.

29、Hongwei Wu; Donge Tang; Fengping Zheng; Shanshan Li; Xinzhou Zhang; Lianghong Yin*; Fanna Liu*; Yong Dai*; Identification of a novel interplay between intestinal bacteria and metabolites in Chinese patients with IgA nephropathy via integrated microbiome and metabolome approaches, Annals of Translational Medicine, 2021,9(1):32

30、Zhihua Zhong; XinYuan; Shizhen Liu; YuerYang; Fanna Liu^*; Machine learning prediction models for prognosis of critically ill patients after openheart surgery, scientific reports, 2021, 11: 83020-83027.   

31、Hongwei Wu; Qiang Li; Lijing Fan; Dewang Zeng; Xianggeng Chi; Baozhang Guan; Bo Hu; Yongping Lu; Chen Yun; Bernhard Krämer; Berthold Hocher^*; Fanna Liua^*; Lianghong Yin^*; Prognostic Value of Serum Magnesium in Mortality Risk among Patients on Hemodialysis: A Meta-Analysis of Observational Studies, kidney disease, 2020, 7: 24-33.  

（1）Fanna Liu; Lianghong Yin. Diagnosis, Treatment, Multidisciplinary Collaborative Therapy and Prevention of Diabetic Foot. Web of science, 2020.  

（2）糖尿病肾病（王文建、杨华章主编）， 参编部分章节，人民卫生出版社、2020-11

（3）血液净化学（王质刚主编），参编部分章节，北京科学技术出版社、2016-09-15、3

（4）慢性肾脏病甲状旁腺功能亢进（张凌、富永芳博），参编部分章节，科学出版社，2023.9

（1）2020年 广东省卫计委适宜技术推广项目 糖尿病肾脏病的多学科联合治疗

（2）2021年 2021ZDZX2042广东省普通高校重点领域专项 系统性红斑狼疮(SLE)甲基化分子诊断计量技术研发应用

（3）2022年广州市校（院）联合资助（登峰医院）基础研究项目202201020080 糖基化磷脂Amadori-PE诱导肾小管上皮细胞铁死亡介导的糖尿病肾病机制研究 25w

（4）2021年度医学教学与教育管理改革研究项目-以泌尿系统为中心的器官整合课程体系的

构建与教学策略创新

（5）2024年广州市科技计划 IgA肾病eccDNA图谱建立及其特异eccDNA标志物研究应用

(1) 发明专利：一种用于血液透析的数据报警方法: ZL2018 11209929.X. 2021.2.26 分类号
G08B21/18(2006.01)I

(2) 发明专利：一种用于血液透析的智能管理系统及方法ZL201811209928.5 2021.10.18

(3) 发明专利：一种血液透析过程中干体重控制系统ZL 201910318743.6  2022.05.10

本科：中英文《内科学》、《诊断学》

硕士、博士 《内科学》

广东省基层医药学会血液净化专委会  理事主任委员

广东省生物医学工程协会理事

广东省女医师协会理事肾脏病与营养代谢分会主任委员

广东省康复医学会肾脏康复分会副主任委员

广东省中西医结合学会代谢肾病专业委员会副主任委员

广东省药理学会内分泌代谢药理专业委员会副主任委员

广东省临床医学医学会血浆净化专业委员会副主任委员

广东省医师协会肾脏内科分会常委