• Attending Physician, Department of Neurology
First Affiliated Hospital of Jinan University

• PhD of Neurology, Postdoctoral Fellow, Assistant Researcher
Academic Master’s Supervisor in Neurology
Jinan University

• Outstanding Young Talent in Clinical Disciplines
English-Taught Course Instructor in Jinan University

• Led research projects including:

• A project funded by the National Natural Science Foundation of China (NSFC) Young Scientist Grant

• A project supported by the China Postdoctoral Science Foundation General Program Fellowship

• A project funded by Guangzhou Basic and Applied Basic Research Program (2025)

• Published 7 SCI-indexed papers as First/Co-First Author (Highest impact factor: 23.213) in internationally renowned journals.

• Filed 40 patents, including 18 utility models and 22 inventions.

• Served as Peer Reviewer for professional journals including:

• BMJ Open Respiratory Research

• Immunity, Inflammation and Disease

• Advances in Therapy

• The Aging Male

• Medical Expertise:
Specializes in the diagnosis and treatment of:

• Cerebrovascular diseases

• Dizziness-related disorders

• Headache and encephalitis

• Other neurological disorders

Sep 2018 – Jul 2021
Jinan University
Ph.D. in Neurology

Sep 2015 – Jul 2018
Shanxi Medical University
Master of Neurology (Combined Bachelor’s and Master’s Program)

Sep 2010 – Jul 2015
Shanxi Medical University
Bachelor of Clinical Medicine (Combined Bachelor’s and Master’s Program)

Jul 2021 – Jul 2023
First Clinical Medical College, Jinan University
Postdoctoral Fellow

Jul 2023 – Present
First Affiliated Hospital of Jinan University
Attending Physician, Department of Neurology

1.

Liu Y, Li Y (Co-first authors), Zang J, Zhang T, Li Y, Tan Z, Ma D, Zhang T, Wang S, Zhang Y, Huang L, Wu Y, Su X, Weng Z, Deng D, Tsang CK, Xu A, Lu D.
CircOGDH Is a Penumbra Biomarker and Therapeutic Target in Acute Ischemic Stroke.
Circ Res. 2022;131(3):642-658.
(JCR Q1, IF=23.213)

2.

Yang WY, Li YF (Co-first authors), Wang ZR, Yu TX, Xu DJ, Yang N, Niu XY, Cai XL, Zhuo WY, Wu XM, Yan M, Zhou JS, Zhang HW, Liang ZG, Wu WJ, Cheng JH, Huang LA, Zhang YS, Guan Y, Tan ZF, Lu D, He N, Dong DW, Zhu HL, Yang B, Shen QY, Xu AD.
Combined Therapy of Intensive Statin plus Intravenous rt-PA in Acute Ischemic Stroke: The INSPIRE Randomized Clinical Trial.
J Neurol. 2021;268(7):2560-2569.
(JCR Q2, IF=6.682)

3.

Li YF (First author), Zhang SX, Ma XW, Xue YL, Gao C, Li XY, Xu AD.
The Proportion of Peripheral Regulatory T Cells in Patients with Multiple Sclerosis: A Meta-Analysis.
Mult Scler Relat Disord. 2019;28:75-80.
(JCR Q3, IF=4.808)

4.

Li YF (First author), Zhang SX, Ma XW, Xue YL, Gao C, Li XY.
Levels of Peripheral Th17 Cells and Serum Th17-Related Cytokines in Patients with Multiple Sclerosis: A Meta-Analysis.
Mult Scler Relat Disord. 2017;18:20-25.
(JCR Q3, IF=4.808)

5.

Hou MM, Li YF (Co-first authors), He LL, Li XQ, Zhang Y, Zhang SX, Li XY.
Proportions of Th17 Cells and Th17-Related Cytokines in Neuromyelitis Optica Spectrum Disorders Patients: A Meta-Analysis.
Int Immunopharmacol. 2019;75:105793.
(JCR Q2, IF=5.714)

6.

Cheng W, Li YF (Co-first authors), Cui L, et al.
Efficacy and Safety of Corticosteroid Treatment in Patients With COVID-19: A Systematic Review and Meta-Analysis.
Front Pharmacol. 2020;11:571156.
(JCR Q2, IF=5.988)

7.

Hou M, Li YF (Co-first authors), He L, Li X, Ding Z, Du Y, Zhang Y, Zhang S, Li X.
Effect of Interferon-Beta Treatment on the Proportion of T Helper 17 Cells and Related Cytokines in Multiple Sclerosis: A Meta-Analysis.
J Interferon Cytokine Res. 2019;39(12):771-779. doi:10.1089/jir.2019.0065
(JCR Q4, IF=3.657)

1.

National Natural Science Foundation of China (NSFC)
Youth Program Grant (No. 82201437)
Mechanistic Study of Neuronal Exosome-Derived CircMAP2 in Acute Ischemic Stroke
Jan 2023 – Dec 2025 | ¥300,000 | Ongoing | Principal Investigator (PI)

2.

Guangzhou Science and Technology Program
Basic and Applied Basic Research Qihang Young Doctoral Researcher Project (No. 2025A043475)
Regulatory Mechanism of Neuronal Exosome-Derived CircMAP2 via Parental Gene in Cerebral Ischemia-Reperfusion Injury
Jan 2025 – Dec 2026 | ¥50,000 | Ongoing | Principal Investigator (PI)

3.

China Postdoctoral Science Foundation
70th Batch General Program Grant (No. 2021M701419)
Exosome-Derived CircMAP2 as a Therapeutic Target and Biomarker in Acute Ischemic Stroke
¥80,000 | Completed | Principal Investigator (PI)

4.

Postdoctoral Start-Up Fund, First Affiliated Hospital of Jinan University
Grant No. 809092
Exosome-Derived CircMAP2 as a Therapeutic Target and Biomarker in Acute Ischemic Stroke
¥50,000 | Completed | Principal Investigator (PI)

Patents (Total: 40)

• Utility Model Patents: 18

• Invention Patents: 22

Representative Patents (10 listed):

1. Yang Zhenguo, Li Yufeng, Zang Jiankun, Lu Dan, Xu Anding.

   Application of Circular RNA circ-FoxO3 in the Preparation of Products for Preventing and Treating Ischemic Stroke.
   China | Patent No. ZL202010945725.3 | Invention Patent | Filed: Sep 10, 2020

2. Li Yufeng, Xue Yulong, Ren Gang, Lü Yan, Dang Jinfeng, Yang Bowen, Li Qi, Zhang Shengxiao, Zhao Haina, Yan Xintong, Du Yaping, He Ping, Li Muchun.
   Heating Device for Enteral Nutritional Formulations.
   China | Patent No. CN201720056162.6 | Utility Model Patent | Filed: Sep 29, 2017

3. Li Xinyi, Li Yufeng, Ren Gang, Wang Yanhong, Li Jieting, Yang Libai, Yu Yaqin, Zhang Shengxiao, Xue Yulong, Yan Xintong, Zhao Haina, Ru Yanni.
   Scrotum and Penis Separation Device.
   China | Patent No. ZL201721056945.0 | Utility Model Patent | Filed: Aug 23, 2017

4. Xu Anding, Liu Yanfang, Lu Dan, Zhang Tianyuan, Li Yufeng, Zang Jiankun, Wu Yousheng, Zeng Zhijun, Li Keshen, Huang Li’an, Zhang Yusheng, Tan Zefeng.
   Application of miR-5112 as a Diagnostic Biomarker for Acute Ischemic Stroke.
   China | Patent No. ZL202111642677.1 | Invention Patent | Filed: [Date omitted in original]

5. Xu Anding, Lu Dan, Liu Yanfang, Zhang Tianyuan, Li Yufeng, Zang Jiankun, Wu Yousheng, Zeng Zhijun, Li Keshen, Huang Li’an, Zhang Yusheng, Tan Zefeng, Wang Shiyong, Li Yaojie.
   Application of Plasma Exosome-Derived CircOGDH as a Diagnostic Biomarker for Acute Ischemic Stroke.
   China | Patent No. ZL202111644699.1 | Invention Patent | Filed: [Date omitted in original]

6. Xu Anding, Lu Dan, Liu Yanfang, Li Yufeng, Zang Jiankun, Zhang Tianyuan, Wu Yousheng, Zeng Zhijun, Li Keshen, Zhang Yusheng, Huang Li’an, Tan Zefeng, Wang Shiyong, Yang Zhenguo.
   Application of circRNA OGDH as a Biomarker for Diagnosing Acute Cerebral Infarction and Predicting Penumbra.
   China | Patent No. ZL202111646380.2 | Invention Patent | Filed: [Date omitted in original]

7. Zhang Shengxiao, Qi Jinshun, Cai Hongyan, Zhang Jun, Ma Xiaowen, Zhao Hui, Wang Qiong, Ren Songjie, Zhang Yuwei, Li Yufeng, Han Shuaihong, Wang Zhaojun, Yuan Li, Wu Meina, Yang Wei, Han Wenxuan, Liu Jinlong, Tong Jian, Wang Shu.
   Use of CJC-1131 Hypoglycemic Drug in Treating Alzheimer’s Disease.
   China | Patent No. CN201410564397.7 | Invention Patent | Filed: Oct 22, 2014

8. Shi Liang, Chen Hao, Jing Ya, Li Yufeng, Zhang Shengxiao, Fan Kai, Ma Xiaowen, Zhang Yuwei, Zheng Chaofeng.
   Chest Lead Electrode Fixation Device for Electrocardiograms.
   China | Patent No. ZL201520856871.3 | Utility Model Patent | Filed: Oct 29, 2015

9. Zhang Shengxiao, Cai Hongyan, Qi Jinshun, Li Haichun, Ma Xiaowen, Li Yufeng, Zhang Yuwei, Ren Songjie, Zhang Jun, Wang Zhaojun, Yuan Li, Sun Lina, Wu Meina, Yang Wei, Yue Xinghua, Zhang Yang, Qiao Feng, Tong Jiaqing, Hao Ming, Yang Ju, Han Yufei, Shi Hui.
   Fully Automated Rodent Delivery Device for Behavioral Studies in Mice and Rats.
   China | Patent No. CN201410300278.0 | Invention Patent | Filed: Jun 27, 2014

10. Zhang Shengxiao, Qi Jinshun, Zhang Jun, Ma Xiaowen, Li Yufeng, Zhang Yuwei, Guo Jinghui, Jiang Tao, Guo Yunfei, Cai Hongyan, Yuan Li, Wang Zhaojun, Wu Meina, Tong Jiaqing, Hao Ming, Yang Ju, Shi Hui, Han Yufei.
    Visualized Minimally Invasive Intracranial Drug Delivery Device.
    China | Patent No. CN201410495649.5 | Invention Patent | Filed: Sep 25, 2014

Neurology