教授/主任医师、硕士及博士生导师、博士后合作导师，疼痛科主任及学科带头人，广东省高等学校“千百十工程”培养对象。岭南名医，第二届“十大我最喜爱的岭南大医生”，羊城好医生。

从事急、慢性疼痛诊疗临床、教学及科研工作30多年。在慢性疼痛性疾病的诊断及治疗方面积累了丰富的临床经验，在带状疱疹后神经痛、肩周炎、膝骨关节炎、颈椎病、腰椎间盘突出症及骨质疏松症等慢性疼痛及慢性顽固性疼痛的治疗和研究方面形成了一套特色医疗和研究方案。

主要研究方向：急慢性疼痛性疾病的分子机理与治疗。主持国家自然科学基金面上项目3项，省部级等基金项目10余项，以通讯/共同通讯作者在《Biomaterials》、《Cellular and Molecular Life Sciences》及《Free Radical Biology and Medicine》等高水平国际期刊上发表SCI收录论文50余篇。培养的博士、硕士获得了“广东省优秀学生”、“暨南大学优秀毕业生”称号及研究生国家奖学金。

参与了2项国家疼痛医疗战略调研及标准制定：2020年《中国疼痛防控与健康促进战略蓝皮书》编写以及《中国疼痛健康指数》调研、编写及发布。牵头编写了《尺神经阻滞专家共识》，《腹直肌鞘阻滞专家共识（2023版）》，《腹横肌平面阻滞中国疼痛学与麻醉学专家共识（2023版）》，《竖脊肌平面阻滞中国疼痛学与麻醉学专家共识（2023版）》及《腰方肌阻滞疗法中国专家共识（2024版）》5部专家共识，参与了《坐骨神经阻滞专家共识（2022版）》，《肋间神经阻滞疗法中国专家共识（2023版）》及《带状疱疹相关疼痛全程管理共识》的编写。

1. 2003.09-2008.06 暨南大学 医学 博士研究生

2. 1994.09-1997.06 南华大学 麻醉学 硕士研究生

3. 1983.09-1986.06 湘南大学 临床医学

1. 2012.11-至今 暨南大学附属第一医院疼痛科科主任主任医师/教授，博士生导师

2. 2008.10-2012.10暨南大学附属第一医院麻醉疼痛科主任医师、副教授、硕士生导师

3. 2002.10－2008.09暨南大学附属第一医院麻醉疼痛科副主任医师、副教授、博士研究生

4. 1997.07－2002.09暨南大学附属第一医院麻醉科主治医师

5. 1986.07－1994.08 湖南省娄底市中心医院麻醉科医师、主治医师

1. 细胞凋亡信号通路及分子机制方面的研究，利用活细胞定量FRET成像技术研究细胞死亡的分子调控机制，建立系统的活细胞定量FRET成像分析技术，研发多种型号的活细胞定量FRET成像分析系统。近年来一直运用原子力显微术（AFM）、FRET、基因质粒技术及荧光发射谱检测分析技术进行单个分子探测、单个细胞超微结构及细胞凋亡分子调控机制的研究，积累了丰富的单分子探测、单个细胞超微结构以及细胞凋亡分子调控研究机制方面的经验。实现了光学成像技术和生物学技术的有机结合，并率先将其运用于软骨细胞凋亡分子调控机理的研究。在《Cellular and Molecular Life Sciences》、《Free Radical Biology and Medicine》、《Journal of Cell Science》、《CellularSignaling》及《Biomaterials》等高水平国际期刊上发表SCI收录论文60多篇。    

  2. 周围神经病理性疼痛分子机制。

主要论文如下（“*”：通讯作者）：

Qiling Tang, Hongce chen, Zihao Mai, Han Sun, LingJun Xu, Guihao Wu, Zhuang Tu, Xuecheng Cheng, Xiaoping Wang* and Tongsheng Chen*. Bim- and Bax-mediated mitochondrial pathway dominates abivertinib-induced apoptosis and ferroptosis. Free Radical Biology and Medicine，2022，180：198–209．

Ge Wu, Zhuang Tu, Fangfang Yang, Zihao Mai, Hongce Chen, Qiling Tang, Xianxin Ye, Kunhao Wang, Xiaoping Wang*, Tongsheng Chen*. Evaluating the inhibitory priority of Bcl-xL to Bad, tBid and Bax by using live-cell imaging assay. Cytometry Part A, 2021, 99(11):  1091–1101

Hongce Chen, Beini Sun, Han Sun, Lingjun Xu, Guihao Wu, Zhuang Tu, Xuecheng Cheng, Xuhong Fan, Zihao Mai, Qiling Tang, Xiaoping Wang*, Tongsheng Chen*. Bak instead of Bax plays a key role in metformin-induced apoptosis in HCT116 cells. Cell Death Discovery，2021，7:363． 

Fangfang Yang, Wenfeng Qu, Mengyan Du, Zihao Mai, Bin Wang, Yunyun Ma, Xiaoping Wang*, Tongsheng Chen*. Stoichiometry and regulation network of Bcl-2 family complexes quantified by live-cell FRET assay. Cellular and Molecular Life Sciences, 2020, 77(12): 2387-2406.

Mengyan Du, Si Yu, Wenhua Su, Mengxin Zhao, Fangfang Yang, Yangpei Liu, Zihao Mai, Yong Wang, Xiaoping Wang*, Tongsheng Chen*. Mitofusin 2 but not mitofusin 1 mediates Bcl-XL-induced mitochondrial aggregation. Journal of Cell Science 2020, 133: jcs245001B.  

Si Yu, Mengyan Du, Ao Yin, Zihao Mai, Yong Wang, Mengxin Zhao, Xiaoping Wang*, Tongsheng Chen*. Bcl-xL inhibits PINK1/Parkin-dependent mitophagy by preventing mitochondrial Parkin accumulation. International Journal of Biochemistry & Cell Biology 2020, 122: 105720.

Yangpei Liu, Yunyun Ma, Zhuang Tu, Chenshuang Zhang, Mengyan Du, Yong Wang, Fangfang Yang, Xiaoping Wang*, Tongsheng Chen*. Mcl-1 inhibits Mff-mediated mitochondrial fragmentation and apoptosis. Biochemical and Biophysical Research Communications, 2020, 523: 620-626.

Yong Wang, Wenhua Su, Zihao Mai, Si Yu, Xiaoping Wang*, Tongsheng Chen*. Anti-apoptotic capacity of Mcl-1 Delta127. Biochemical and Biophysical Research Communications, 2020, 526 : 1042-1048.

Bin Wang, Zihao Mai, Mengyan Du, Lu Wang, Fangfang Yang, Yunyun Ma, Xiaoping Wang*, Tongsheng Chen*. BCL-XL directly retrotranslocates the monomeric BAK. Cellular signaling, 2019, 61: 1-9．

Junlin Wen, Zihao Mai, Mengxin Zhao, Xiaoping Wang*, Tongsheng Chen. Full anti-apoptotic function of Bcl-XL complexed with Beclin-1 verified by live-cell FRET assays. Biochemical and Biophysical Research Communications, 2019, 511:700-704.

Lingjun Xu, Cuicui Liu, Lumiao Chen, Guihao Wu, Xiaoping Wang*. Reduction of SIRT1 mediates Osteoarthritic Pain by Upregulating p53 Expression. Pain physician, 2021, 24: E1025-E1034.

Shenyu Yang, Qiuju Miao, Yiping Huang, Peishan Jian, Xiaoping Wang*, Mei Tu*. Preparation of cinnamaldehyde-loaded polyhydroxyalkanoate/chitosan porous microspheres with adjustable controlled-release property and its application in fruit preservation. Food Packaging and Shelf Life, 2020, 26: 100596.

Yingyao Quan, Qiang Xia, Yuhong Liu, Chunmei Lin, Shengnan Wu, Xiaoping Wang∗, Tongsheng. Inhibitory Effects of Free and Nano- Liposomal-Loaded Resveratrol on Sodium Nitroprusside-Induced Rabbit Chondrocyte Apoptosis. Journal of Nanoscience and Nanotechnology, 2017, 17(3): 1740-1746.

Yingyao Quan, Guiqi Qin, Hao Huang, Yuhong Liu, Xiaoping Wang*, Tongsheng Chen*. Dominant roles of Fenton reaction in sodium nitroprusside-induced chondrocyte apoptosis. Free Radical Biology and Medicine, 2016，94: 135-144.

Hao Huang, Yingyao Quan, Xiaoping Wang*, Tongsheng Chen. Gold Nanoparticles of Diameter 13 nm Induce Apoptosis in Rabbit Articular Chondrocytes. Nanoscale Research Letters, 2016, 11:249.

Qian Liang, Xiaoping Wang*, Tong-sheng Chen. Resveratrol protects rabbit articular chondrocyte against sodium nitroprusside-induced apoptosis via scavenging ROS. Apoptosis, 2014, 19 (9):1354-1363.

(1) Yongtong Zhan, Lingao Dai, Ze Fu, Xuhong Fan, Xin Li, Guihao Wu, Yue Ni, Ge Wu, Tongsheng Chen, Xiaoping Wang*. Live-cell FRET assay on the stoichiometry and affinity of the YAP complexes in MCF-7 cells. Archives of Biochemistry and Biophysics, 2025, 765: 110305.

(2) Yongtong Zhan, Guihao Wu, Xuhong Fan, Ze Fu, Yue Ni, Beini Sun, Hongce Chen, Tongsheng Chen, Xiaoping Wang*. YAP upregulates AMPKα1 to induce cancer cell senescence. International Journal of Biochemistry and Cell Biology. 2024, 170(3): 106559.

(3) Ze Fu, Xin Xin, Yongtong Zhan, Xuhong Fan, Xin Li, Tongsheng Chen and Xiaoping Wang*. GPER agonist G-1 activates YAP to induce apoptosis in breast cancer cells, Journal of Steroid Biochemistry and Molecular Biology 2025, 248：106693.

(4) Xuhong Fan, Yuting He, Guihao Wu, Hongce Chen, Xuecheng Cheng, Yongtong Zhan, Chunchun An, Tongsheng Chen, Xiaoping Wang*. Sirt3 activates autophagy to prevent DOX-induced senescence by inactivating PI3K/AKT/mTOR pathway in A549 cells. Biochim Biophys Acta Molecular Cell Research, 2023, 1870(2): 119411.

(5) Xiang Huang, Dacheng Tang, Pan Chen, Lumiao Chen, Xiaohong Li,* and Xiaoping Wang*. Laser speckle contrast imaging to predict the effect of temporary spinal cord stimulation in postherpetic neuralgia patients: A prospective observational study. Journal of Innovative Optical Health Sciences，2023，235001.

(6) Xiaohong Li, Pan Chen, Jian He, Xiang Huang, Dacheng Tang, Lumiao Chen, and Xiaoping Wang*. Comparison of the Efficacy and Safety of Temporary Spinal Cord Stimulation versus Pulsed Radiofrequency for Postherpetic Neuralgia: A Prospective Randomized Controlled Trial.Pain Research and Management，2022, 3880424.

(7) Qiling Tang, Hongce chen, Zihao Mai, Han Sun, LingJun Xu, Guihao Wu, Zhuang Tu, Xuecheng Cheng, Xiaoping Wang* and Tongsheng Chen*. Bim- and Bax-mediated mitochondrial pathway dominates abivertinib-induced apoptosis and ferroptosis. Free Radical Biology and Medicine，2022，180：198–209．

(8) Wu G, Li X, Zhan Y, Fan X, Xu L, Chen T, Wang X*. BID- and BAX-mediated mitochondrial pathway dominates A-1331852-induced apoptosis in senescent A549 cells [J]. Biochemical and Biophysical Research Communications, 2022, 627: 160-167.

(9) Wu G, Zhang C, Xu L, Chen H, Fan X, Sun B, Tang Q, Zhan Y, Chen T, Wang X*. BAK plays a key role in A-1331852-induced apoptosis in senescent chondrocytes. Biochemical and Biophysical Research Communications, 2022, 609: 93-99.

(10) Yang Shenyu, Miao Qiuju, Huang Yiping , Wang Xiaoping*, Tu Mei*. Preparation of cinnamaldehyde-loaded polyhydroxyalkanoate/ chitosan porous microspheres with adjustable controlled-release property and its application in fruit preservation. Food Packaging and Shelf Life, 2020, 26: 100596.

(11) Fangfang Yang, Wenfeng Qu, Mengyan Du, Zihao Mai, Bin Wang, Yunyun Ma, Xiaoping Wang*, Tongsheng Chen*. Stoichiometry and regulation network of Bcl-2 family complexes quantified by live-cell FRET assay. Cellular and Molecular Life Sciences, 2020, 77(12): 2387-2406.

(12) Zhao Mengxin, Wen Junlin, Wang Lu, Wang Xiaoping*, Chen Tongsheng. Intracellular catalase activity instead of glutathione level dominates the resistance of cells to reactive oxygen species[J]. Cell Stress and Chaperones, 2019:1-1.

(13) Junlin Wen, Zihao Mai, Mengxin Zhao, Xiaoping Wang*, Tongsheng Chen. Full anti-apoptotic function of Bcl-XL complexed with Beclin-1 verified by live-cell FRET assays. Biochemical and Biophysical Research Communications, 2019, 511(3):700-704.

(14) Chunmei Lin，Gaina Xi, Li Tan, Xiaoping Wang*, Tongsheng Chen. Covalent linking peptide to hydrothermally reduced graphene oxide for ultrasensitive detection of matrix metalloproteinase 9. Applied nanoscience, 2017, 7(8): 723-730. 

(15) Hao Huang, Ying-Yao Quan, Xiaoping Wang*, Tong-Sheng Chen. Gold Nanoparticles of Diameter 13 nm Induce Apoptosis in Rabbit Articular Chondrocytes. Nanoscale Res Lett, 2016, 11:249 (10 pages). (2区, *通讯作者SCI IF2.5843).

(16) Ying-Yao Quan, Gui-Qi Qin, Hao Huang, Yu-Hong Liu, Xiao-Ping Wang*, Tong-Sheng Chen*. Dominant roles of Fenton reaction in sodium nitroprusside-induced chondrocyte apoptosis. Free Radical Biology and Medicine, 2016, 94: 135-144. 

近年的主要科研项目（第一主持人及博士后合作导师）

1) 国家自然科学基金面上项目，81572184，YAP蛋白活化分子调控机制的活细胞定量成像分析研究，2023-01至2026-12，59万元，在研，王小平；

2) 国家自然科学基金面上项目，81572184，还原氧化石墨烯-白藜芦醇纳米复合体干预骨关节炎软骨退变的分子机制研究，2016-01至2019-12，57万元，已结题，王小平；

3) 国家自然科学基金青年项目，82002286，仿生自组装构建生物响应性骨修复材料引发的免疫微环境时空调控巨噬细胞促进血管化的机制研究，2021-01至2023-12，16万元，已结题，杨慎宇博士后主持，合作导师王小平；

4) 国家自然科学基金青年项目，82002930，核糖体蛋白RPS15A通过调控 EGFR 在食管鳞癌进展中的作用及机制研究，2021-01至2023-12，16万元，已结题，周朋君博士后主持，合作导师王小平

5) 广东省自然科学基金项目，2021A1515012186，结合荧光共振能量转移技术研究Bcl-2家族蛋白调控软骨细胞衰老的分子机制，2021-01至2023-12，10万元，已结题，王小平；

6) 广东省基础与应用基础研究基金区域联合基金项目，2020A1515111041，仿生自组装构建生物响应性骨修复材料引发的免疫微环境时空调控巨噬细胞促进血管化的机制研究，2021-01至2023-12，10万元，已结题，杨慎宇博士后主持，合作导师王小平；

7) 中国博士后科学基金特别资助，2020T1130253，炎症响应性多级仿生骨修复材料的构建及其调控牙周炎骨缺损修复的机制，2020-01至2021-12，18万元，已结题，杨慎宇博士后主持，合作导师王小平；

8) 中国博士后科学基金面上项目，2019M663384，定向组装构建仿成熟骨取向板层状支架促进骨再生的研究，2020-01至2021-12，8万元，已结题，杨慎宇博士后主持，合作导师王小平；

9) 中国博士后科学基金面上项目，2019M663398，核糖体蛋白 S15a调控食管鳞癌细胞增殖的分子机制研究，2020-01至2021-12，8万元，已结题，周朋君博士后主持，合作导师王小平

10) 中国博士后科学基金面上项目，2019M653289，I-IFN介导的JAK1/STAT1-STAT2信号通路局麻药神经毒性损伤中的作用，2020-01至2021-12，8万元，已结题，文先杰博士后主持，合作导师王小平

11) 广州市科技计划项目-基础研究计划-市校（院）联合资助项目，202102010039，BH3模拟物诱导衰老软骨细胞凋亡在骨关节炎中的作用和分子机制研究，2021-4至2023-3，20万元，已结题，王小平。

1. 中华医学会疼痛学分会全国委员

2. 中国医师协会疼痛科医师分会全国委员

3. 中国女医师协会疼痛专业委员会副主任委员

4. 广东省女医师协会疼痛专业委员会主任委员

5. 广东省医学会疼痛学分会副主任委员兼神经病理性疼痛学组组长

6. 粤港澳大湾区疼痛专科医师联盟副主任

7. 广东省疼痛质控中心副主任