郭瑞，男，博士，研究员、博导。第九届广州科技创新南山奖获得者，国家药品监督管理局医疗器械技术审评专家，广东省药品监督管理局医疗器械注册许可专家，中国生物材料学会口腔颅颌面材料分会副主委，广东省生物医用材料与海洋生物材料工程技术研究中心主任，广东省细胞生物学学会常务理事，广东省生物医学工程学会生物3D打印与再生医学分会副主委。科技部、国家自然科学基金委、广东省科技厅、广东省自然资源厅、广州市科技局和广州市工业和信息化局等专家库专家。主要研究方向：新型组织诱导再生材料的构建及产业化。承担/参与国家重点研发计划政府间国际科技创新合作重点专项、国家重点研发计划、广东省重点研发计划、广州市重点研发计划等省部级以上项目近20项，获批科研经费近2000万元。以第一作者/通讯作者在Advanced Functional Materials、Advanced Science、Biomaterials、Bioactive Materials等本领域Top杂志上发表论文90多篇，H指数45，入选美国斯坦福大学和 Elsevier 数据库发布的2024全球前2%顶尖科学家榜单；申请发明专利100多件。获得第二十二届、二十三届、二十四届中国专利优秀奖（排名第一），第七届广东专利金奖（排名第一）和军队科技进步二等奖（排名第二）各1项。担任Frontiers in Bioengineering and Biotechnology和Frontiers in Materials副主编，同时担任Advanced Materials、Advanced Functional Materials、Biomaterials、Theranostics、Acta Biomaterialia等国际杂志的审稿人，受邀做各种学术及产业论坛报告近20场次。开发的医疗器械产品取得II类注册证8个，另外还有多个II类和III类创新产品正在准备申报资料。

新型组织诱导再生材料的构建及产业化

近5年学术论文：

2025

1.         Xiaoling Cao, Yonghao Deng, Zhongye Xu, Tingting Wang, Bing Tang, Jiande Han, Rui Guo*, Rong Yin*. A versatile natural gelatin-based hydrogel for emergency wound treatment through hemostasis, antibacterial, and anti-inflammation. Biofabrication. 2025, 17, 015017.

2024

2.         DONGMING LV, ZHONGYE XU, HAO YANG, YANCHAO RONG, ZIRUI ZHAO, ZHICHENG HU, RONG YIN, RUI GUO*, XIAOLING CAO*, BING TANG*. Hollow Bismuth Nanoparticle-Loaded Gelatin Hydrogel Regulates M2 Polarization of Macrophages to Promote Infected Wound Healing. Biomaterials Research. 2024, 28, 0105.

3.         Yifan Hao, Longbao Feng, Huiling Liu, Liming Zhou, Xiang Yu, Xinyue He, Huan Cheng, Long Jin, Changyong Wang*, Rui Guo*. Bioactive hydrogel synergizes neuroprotection, macrophage polarization, and angiogenesis to improve repair of traumatic brain injury. Materials Today Bio. 2024, 29, 101335. https://doi.org/10.1016/j.mtbio.2024.101335.

4.         Rong Xiao, Longbao Feng, Xinyue He, Yifan Hao, Zhong Cao, Aliaksandr Astrowski, Yi Zhang*, Rui Guo*. Photothermal and Immunomodulatory Hydrogels Loaded with Black Phosphorus Nanosheets and Curcumin for Wound Healing. ACS Applied Nano Materials.2024.

5.         Xinyue He, Lianghong Peng, Liming Zhou, Huiling Liu, Yifan Hao, Yuhan Li, Zijin lv, Baohui Zeng, Xinmin Guo*, Rui Guo*. A biphasic drug-releasing microneedle with ROS scavenging and angiogenesis for the treatment of diabetic ulcers. Acta Biomaterialia. 2024, 189: 270-285. https://doi.org/10.1016/j.actbio.2024.09.045.

6.         Juanjuan Li, Cheng Peng, Caiqiang Huang, Li Wan, Ke Wang, Ping Wu, Tianjun Chen, Guodong Sun*, Rui Guo*, Hongsheng Lin*, Zhisheng Ji*. Metal Ruthenium Complexes Treat Spinal Cord Injury By Alleviating Oxidative Stress Through Interaction With Antioxidant 1 Copper Chaperone Protein. Advanced Science. 2024; 2407225.

7.         Meng Wang, Rui Cai, Zhiwu Zhang, Longbao Feng, Ziying Lei, Fengpin Wang, Zhongjian Yu, Lu Liu, Xia Yang, Huili Guo, Bingjie Shan, Shiting Xu, Rui Guo*, Shuzhong Cui*, Yanfang Zheng*. NIR-responsive CN-Pt-GEM hydrogel induces necroptosis and immunotherapeutic responses prevent postoperative recurrence and wound infection in lung carcinoma. Journal of Nanobiotechnology. 2024 22, 355.

8.         Yang Hu, Liming Zhou, Zhenning Wang, Zhiming Ye, Huiling Liu, Yi Lu, Zhihui Qi, Kunhua Yang, Jianhao Zeng, Huimin Li, Ruizhe Tang, Jiaoyan Ren*, Rui Guo*, Maojin Yao*. Assembled Embedded 3D Hydrogel System for Asynchronous Drug Delivery to Inhibit Postoperative Recurrence of Malignant Glioma and Promote Neurological Recovery. Advanced Functional Materials. 2024; 2401383.

9.         Huiling Liu, Yang Jiao, T. Forouzanfar, Gang Wu *, Rui Guo*, Haiyan Lin *. High-strength double-network silk fibroin based hydrogel loaded with Icariin and BMSCs to inhibit osteoclasts and promote osteogenic differentiation to enhance bone repair. Biomaterials Advances. 2024, 160, 213856.

10.     PinLi Lin, Xiaona Tang, Jintao Zhong, Fang Tang, Hanjiao Liu, Lu Peng, Biyu Wan, Mengya Wang, Yuling Ye, Rui Guo*, Xusheng Liu*, Lili Deng*. Antibacterial, ROS scavenging and angiogenesis promoting epsilon-Polylysine/gelatin based hydrogel containing CTLP to regulate macrophages for pressure ulcer healing. Biofabrication. 2024, 16, 025025.

11.     Liming Zhou, Huiling Liu, Borui Zhang, Chengxiu Wei, Shihao Zhou, Xiaoying Huang, Xiaoxuan Zhong, Li Zhang, Wei Bi, Jianghui Liu, Yizhi Liang, Long Jin, Rui Guo*. A Novel 3D-Printed Bi-Layer Cranial-Brain Patch Promotes Brain Injury Repair and Bone Tissue Regeneration. Advanced Functional Materials. 2024; 2314330.

12.     Ting Sun, Zhiqiang Feng, Wenpeng He, Chufeng Li, Songning Han, Zejian Li, Rui Guo*. Novel 3D-printing bilayer GelMA-based hydrogel containing BP, β-TCP and exosomes for cartilage-bone integrated repair. Biofabrication. 2024, 16, 015008.（ESI高被引论文）

2023

13.     Chengxiu Wei, Chuangang You, Liming Zhou, Huiling Liu, Shihao Zhou, Xingang Wang, Rui Guo*. Antimicrobial hydrogel microneedle loading verteporfin promotes skin regeneration by blocking mechanotransduction signaling. Chemical Engineering Journal. 2023, 472, 144866.

14.     Nanbo Liu, Shuoji Zhu, Yuzhi Deng, Ming Xie, Mingyi Zhao, Tucheng Sun, Changjiang Yu, Ying Zhong, Rui Guo*, Keluo Cheng*, Dehua Chang*, Ping Zhu*. Construction of multifunctional hydrogel with metal-polyphenol capsules for infected full-thickness skin wound healing. Bioactive Materials.2023, 24:69-80.

15.     Shubin Chong, Chengxiu Wei, Longbao Feng, Rui Guo*. Silk Fibroin-Based Hydrogel Microneedles Deliver α-MSH to Promote Melanosome Delivery for Vitiligo Treatment. ACS Biomaterials Science & Engineering. 2023.

16.     Longbao Feng, Yu Liu, Yini Chen, Qi Xiang, Yadong Huang, Zonghua Liu*, Wei Xue*, Rui Guo*. Injectable Antibacterial Hydrogel with Asiaticoside-Loaded Liposomes and Ultrafine Silver Nanosilver Particles Promotes Healing of Burn-Infected Wounds. Advanced Healthcare Materials. 2023, 12 (22): 2203201.

2022

17.     Weidong Zhu, Yunqing Dong, Pengcheng Xu, Qiao Pan, Keyao Jia, Panshi Jin, Mou Zhou, Yubing Xu, Rui Guo*, Biao Cheng*. A composite hydrogel containing resveratrol-laden nanoparticles and platelet-derived extracellular vesicles promotes wound healing in diabetic mice. Acta Biomaterialia. 2022.154, 212-230. DOI: 10.1016/j.actbio.2022.10.038.

18.     Rui Cai, Meng Wang, Meiyuan Liu, Xiongjie Zhu, Longbao Feng, Zhongjian Yu, Xia Yang, Zhiwu Zhang, Huili Guo, Rui Guo*, Yanfang Zheng *. An iRGD-conjugated photothermal therapy-responsive gold nanoparticle system carrying siCDK7 induces necroptosis and immunotherapeutic responses in lung adenocarcinoma. Bioengineering & Translational Medicine. 2022.

19.     Peng Luo, Jiarui Fang, Dazhi Yang, Lan Yu, Houqing Chen, Changging Jiang, Rui Guo*, Tao Zhu*, Shuo Tang*. OP3-4 peptide sustained-release hydrogel inhibits osteoclast formation and promotes vascularization to promote bone regeneration in a rat femoral defect model. Bioengineering & Translational Medicine. 2022.

20.     Chuyao Chen, Shaoshan Huang, Zelong Chen, Qin Liu, Yu Cai, Yingjie Mei, Yikai Xu*, Rui Guo*, Chenggong Yan*. Kartogenin (KGN)/synthetic melanin nanoparticles (SMNP) loaded theranostic hydrogel scaffold system for multiparametric magnetic resonance imaging guided cartilage regeneration. Bioengineering & Translational Medicine. 2022.

21.     Lisheng Zhou, Liming Zhou, Chengxiu Wei, Rui Guo*. A bioactive dextran-based hydrogel promote the healing of infected wounds via antibacterial and immunomodulatory. Carbohydrate Polymers. 2022, 291 119558.

22.     Shanghui Huang, Xiangqian Hong, Mingyi Zhaod, Nanbo Liu, Huiling Liu, Jun Zhao, Longquan Shao, Wei Xue, Han Zhang*, Ping Zhu*, Rui Guo*. Nanocomposite hydrogels for biomedical applications. Bioengineering & Translational Medicine. 2022, DOI: 10.1002/btm2.10315.

23.     Liming Zhou, Nanbo Liu, Longbao Feng, Mingyi Zhao, Peng Wu, Yunfei Chai, Jian Liu*, Ping Zhu*, Rui Guo*. Multifunctional electrospun asymmetric wettable membrane containing black phosphorusRg1 for enhancing infected wound healing. Bioengineering & Translational Medicine. 2022; 7(2): e10274, DOI:10.1002/btm2.10274.

2021

24.     Shikun Wei, Pengcheng Xu, ZexinYao, Xiao Cui, Xiaoxuan Lei, Linlin Li, Yunqing Dong, WeidongZhu, Rui Guo*, Biao Cheng*. A composite hydrogel with co-delivery of antimicrobial peptides and platelet-rich plasma to enhance healing of infected wounds in diabetes. Acta Biomaterialia. 2021 124, 1 April 2021, 205-218. DOI: 10.1016/j.actbio.2021.01.046.（ESI高被引论文）

25.     Yuanyuan Zheng, Xiangqian Hong, Jiantao Wang, Longbao Fen, Taojian Fan, Rui Guo*, Han Zhang*. 2D Nanomaterials for Tissue Engineering and Regenerative Nanomedicines Recent Advances and Future Challenges. Advanced Healthcare Materials. 2021, 10 (7): 2001743. DOI: 10.1002/adhm.202001743.

26.     Kui Lu, Keke Li, Min Zhang, Zhaoxin Fang, Panpan Wu, Longbao Feng, Kaixian Deng, Changjiang Yu, Yuzhi Deng, Yang Xiao*, Ping Zhu*, Rui Guo*. Adipose-derived stem cells (ADSCs) and platelet-rich plasma (PRP) loaded gelatin/silk fibroin hydrogels for improving healing in a murine pressure ulcer model. Chemical Engineering Journal. 2021, 424, 130429.

承担的部分科研项目：

1.2022年国家重点研发计划政府间国际科技创新合作重点专项（2022YFE0122200），免疫调控水凝胶调节巨噬细胞促进糖尿病创面修复与再生的研究，2023-01-01至2024-12-31，100万。（主持）

2.2022年国家重点研发计划（2022YFC2403100），基于重组人胶原蛋白的三维光刻通孔多梯度高仿生真皮支架研制，2022-11-01至2025-10-31，799万，课题二：重组人胶原及纤连蛋白的设计、合成与评价（2022YFC2403102），160万。（课题负责人）

3.2024年广州市重点研发计划项目（2024B03J1244），角化龈组织再生修复膜的研发与产业化，2024-04-01至2027-03-31，100万。（主持）

4.2022年广东省国际科技合作领域项目（2022A0505050046），负载外泌体的功能化水凝胶促进慢性创面修复的研究，2022-01-01至2023-12-31，50万。（主持）

5.2019年广东省国际科技合作领域项目（2018A050506040），负载脐带间充质干细胞的抗感染水凝胶修复糖尿病创面的研究，2018-10-01至2020-10-01，100万。（主持）

1.中国专利，郭瑞，薛巍，冯龙宝，刘璇，一种谷胱甘肽响应型双载药物聚合物胶束及其制备方法与应用，授权，2020.3.17, CN201710271155.2

2.中国专利，郭瑞，冯龙宝，周莉明，一种负载抗菌肽的可自愈水凝胶创面敷料及其制备方法，授权，2023.2.3，CN202111342128.2

3.中国专利，薛巍，郭瑞，刘宗华，冯龙宝，一种抗菌水凝胶及其制备方法和应用，授权，2023.5.30，CN202210885532.2