郭瑞，男，1982年3月生，博士，研究员、博导。第九届广州科技创新南山奖获得者，国家药品监督管理局医疗器械技术审评专家，广东省药品监督管理局医疗器械注册许可专家，中国生物材料学会口腔颅颌面材料分会副主委，广东省生物医用材料与海洋生物材料工程技术研究中心主任，广东省细胞生物学学会常务理事，广东省生物医学工程学会生物3D打印与再生医学分会副主委。科技部、国家自然科学基金委、广东省科技厅、广东省自然资源厅、广州市科技局和广州市工业和信息化局等专家库专家。主要研究方向为：新型组织诱导再生材料的构建及产业化。承担/参与国家重点研发计划政府间国际科技创新合作重点专项、国家重点研发计划、广东省重点研发计划、广州市重点研发计划等省部级以上项目近20项，获批科研经费近2000万元。以第一作者/通讯作者在Biomaterials、Bioactive Materials、Chemical Engineering Journal、Acta Biomaterialia等本领域Top杂志上发表论文80多篇，总被引近4000次，H指数39，入选美国斯坦福大学和 Elsevier 数据库发布的2023全球前2%顶尖科学家榜单；申请发明专利100多件。获得第二十二届、二十三届、二十四届中国专利优秀奖（排名第一），第七届广东专利金奖（排名第一）和军队科技进步二等奖（排名第二）各1项。担任Frontiers in Bioengineering and Biotechnology和Frontiers in Materials副主编，同时担任Advanced Materials、Advanced Functional Materials、Biomaterials、Theranostics、Acta Biomaterialia、ACS Applied Materials & Interfaces等国际杂志的审稿人，受邀做各种学术及产业论坛报告近20场次。开发的医疗器械产品取得II类注册证7个，另外还有多个II类和III类创新产品正在准备申报资料。

新型组织诱导再生材料的构建及产业化

近5年学术论文：

2023

1.         Chengxiu Wei, Chuangang You, Liming Zhou, Huiling Liu, Shihao Zhou, Xingang Wang, Rui Guo*. Antimicrobial hydrogel microneedle loading verteporfin promotes skin regeneration by blocking mechanotransduction signaling. Chemical Engineering Journal. 2023, 472, 144866.

2.         Nanbo Liu, Shuoji Zhu, Yuzhi Deng, Ming Xie, Mingyi Zhao, Tucheng Sun, Changjiang Yu, Ying Zhong, Rui Guo*, Keluo Cheng*, Dehua Chang*, Ping Zhu*. Construction of multifunctional hydrogel with metal-polyphenol capsules for infected full-thickness skin wound healing. Bioactive Materials.2023, 24:69-80.

3.         Shubin Chong, Chengxiu Wei, Longbao Feng, Rui Guo*. Silk Fibroin-Based Hydrogel Microneedles Deliver α-MSH to Promote Melanosome Delivery for Vitiligo Treatment. ACS Biomaterials Science & Engineering. 2023, DOI: 10.1021/acsbiomaterials.3c00284.

4.         Longbao Feng, Yu Liu, Yini Chen, Qi Xiang, Yadong Huang, Zonghua Liu*, Wei Xue*, Rui Guo*. Injectable Antibacterial Hydrogel with Asiaticoside-Loaded Liposomes and Ultrafine Silver Nanosilver Particles Promotes Healing of Burn-Infected Wounds. Advanced Healthcare Materials. 2023, DOI: 10.1002/adhm.202203201.

2022

5.         Weidong Zhu, Yunqing Dong, Pengcheng Xu, Qiao Pan, Keyao Jia, Panshi Jin, Mou Zhou, Yubing Xu, Rui Guo*, Biao Cheng*. A composite hydrogel containing resveratrol-laden nanoparticles and platelet-derived extracellular vesicles promotes wound healing in diabetic mice. Acta Biomaterialia. 2022.154, 212-230. DOI: 10.1016/j.actbio.2022.10.038.

6.         Rui Cai, Meng Wang, Meiyuan Liu, Xiongjie Zhu, Longbao Feng, Zhongjian Yu, Xia Yang, Zhiwu Zhang, Huili Guo, Rui Guo*, Yanfang Zheng *. An iRGD-conjugated photothermal therapy-responsive gold nanoparticle system carrying siCDK7 induces necroptosis and immunotherapeutic responses in lung adenocarcinoma. Bioengineering & Translational Medicine. 2022, https://doi.org/10.1002/btm2.10430.

7.         Peng Luo, Jiarui Fang, Dazhi Yang, Lan Yu, Houqing Chen, Changging Jiang, Rui Guo*, Tao Zhu*, Shuo Tang*. OP3-4 peptide sustained-release hydrogel inhibits osteoclast formation and promotes vascularization to promote bone regeneration in a rat femoral defect model. Bioengineering & Translational Medicine. 2022, https://doi.org/10.1002/btm2.10414.

8.         Chuyao Chen, Shaoshan Huang, Zelong Chen, Qin Liu, Yu Cai, Yingjie Mei, Yikai Xu*, Rui Guo*, Chenggong Yan*. Kartogenin (KGN)/synthetic melanin nanoparticles (SMNP) loaded theranostic hydrogel scaffold system for multiparametric magnetic resonance imaging guided cartilage regeneration. Bioengineering & Translational Medicine. 2022, http://doi.org/10.1002/btm2.10364.

9.         Lisheng Zhou, Liming Zhou, Chengxiu Wei, Rui Guo*. A bioactive dextran-based hydrogel promote the healing of infected wounds via antibacterial and immunomodulatory. Carbohydrate Polymers. 2022, 291 119558. https://doi.org/10.1016/j.carbpol.2022.119558.

10.     Shanghui Huang, Xiangqian Hong, Mingyi Zhaod, Nanbo Liu, Huiling Liu, Jun Zhao, Longquan Shao, Wei Xue, Han Zhang*, Ping Zhu*, Rui Guo*. Nanocomposite hydrogels for biomedical applications. Bioengineering & Translational Medicine. 2022, DOI: 10.1002/btm2.10315.

11.     Liming Zhou, Nanbo Liu, Longbao Feng, Mingyi Zhao, Peng Wu, Yunfei Chai, Jian Liu*, Ping Zhu*, Rui Guo*. Multifunctional electrospun asymmetric wettable membrane containing black phosphorusRg1 for enhancing infected wound healing. Bioengineering & Translational Medicine. 2022; 7(2):e10274, DOI:10.1002/btm2.10274.

2021

12.     Shikun Wei, Pengcheng Xu, ZexinYao, Xiao Cui, Xiaoxuan Lei, Linlin Li, Yunqing Dong, WeidongZhu, Rui Guo*, Biao Cheng*. A composite hydrogel with co-delivery of antimicrobial peptides and platelet-rich plasma to enhance healing of infected wounds in diabetes. Acta Biomaterialia. 2021 124, 1 April 2021, 205-218. DOI: 10.1016/j.actbio.2021.01.046.

13.     Yuanyuan Zheng, Xiangqian Hong, Jiantao Wang, Longbao Fen, Taojian Fan, Rui Guo*, Han Zhang*. 2D Nanomaterials for Tissue Engineering and Regenerative Nanomedicines Recent Advances and Future Challenges. Advanced Healthcare Materials. 2021, 10(7): 2001743. DOI: 10.1002/adhm.202001743.

14.     Kui Lu, Keke Li, Min Zhang, Zhaoxin Fang, Panpan Wu, Longbao Feng, Kaixian Deng, Changjiang Yu, Yuzhi Deng, Yang Xiao*, Ping Zhu*, Rui Guo*. Adipose-derived stem cells (ADSCs) and platelet-rich plasma (PRP) loaded gelatin/silk fibroin hydrogels for improving healing in a murine pressure ulcer model. Chemical Engineering Journal. 2021, 424, 130429.

15.     Xiongjie Zhu, Zhongjian Yu, Longbao Feng, Lian Deng, Zhaobi Fang, Zhile Liu, Ying Li, Xiaoran Wu, Lingyu Qin, Rui Guo*, Yanfang Zheng*. Chitosan-based nanoparticle co-delivery of docetaxel and curcumin ameliorates anti-tumor chemoimmunotherapy in lung cancer. Carbohydrate Polymers. 2021, 268, 118237. DOI: 10.1016/j.carbpol.2021.118237.

2020

16.     Huiling Liu, Xiaolan Zhu, Huiming Guo, Huanlei Huang, Shanghui Huang, Shaoshan Huang, Wei Xue, Ping Zhu, Rui Guo*. Nitric oxide released injectable hydrogel combined with synergistic photothermal therapy for antibacterial and accelerated wound healing. Applied Materials Today. 20 (2020) 100781. DOI: 10.1016/j.apmt.2020.100781.

17.     Yuanyuan Zheng, Weihao Yuan, Huiling Liu, Shaoshan Huang, Liming Bian, Rui Guo*. Injectable supramolecular gelatin hydrogels loading resveratrol and histatin-1 for burn wound therapy. Biomaterials Science. 2020, 8 (17), 4810-4820. DOI: 10.1039/D0BM00391C.

18.     Shanghui Huang, Huiling Liu, Shaoshan Huang, Tingling Fu, Wei Xue, Rui Guo*. Dextran methacrylate hydrogel microneedles loaded with doxorubicin and trametinib for continuous transdermal administration of melanoma. Carbohydrate Polymers. 246 (15), 2020, 116650.

19.     Mengdi Zhang, Zengliang Wang, Pengzhou Huang, Guanwei Jiang, Changpeng Xu, Wentao Zhang, Rui Guo*, Wenqiang Li*, Xintao Zhang*. Real-time and noninvasive tracking of injectable hydrogel degradation using functionalized AIE nanoparticles. Nanophotonics. 2020, 9 (7): 2063-2075. DOI: https://doi.org/10.1515/nanoph-2020-0087.

2019

20.     Xinlu Wang, Pengcheng Xu, Zexin Yao, Qi Fang, Longbao Feng, Rui Guo*, Biao Cheng*. Preparation of antimicrobial hyaluronic acid/quaternized chitosan hydrogels for the promotion of seawater immersion wound healing. Frontiers in Bioengineering and Biotechnology. 2019, DOI: 10.3389/fbioe.2019.00360.

21.     Zhigang Fang, Xiaozhen Wang, Yanling Sun, Ruifang Fan, Zhong Liu, Rui Guo*,Deming Xie*. Sgc8 aptamers targeted glutathione-responsive nanoassemblies containing Ara-C prodrug for the treatment of acute lymphoblastic leukemia. Nanoscale. 2019, 11, 23000-23012. DOI: 10.1039/C9NR07391D.

22.     Peng Wang, Shaobin Huang, Zhicheng Hu, Wei Yang, Yong Lan, Jiayuan Zhu, Andrei Hancharou, Rui Guo*,Bing Tang*. In situ formed anti-inflammatory hydrogel loading plasmid DNA encoding VEGF for burn wound healing. Acta Biomaterialia.2019, 100, 191-201. DOI: 10.1016/j.actbio.2019.10.004.

23.     Yang Wei, Zhu Ping, Huang Huanlei, Zheng Yuanyuan, Liu Jian, Feng Longbao, Guo Huiming*, Tang Shuo*, Rui Guo*. Functionalization of Novel Theranostic Hydrogels with Kartogenin Grafted USPIO Nanoparticles to Enhance Cartilage Regeneration. ACS Applied Materials & Interfaces.2019, 11, 34744-34754.

24.     Hongjie Xu, Shanghui Huang, Jingjing, Wang, Yong Lan, Longbao Feng, Meishu Zhu, Yang Xiao, Biao Cheng, Wei Xue, Rui Guo*. Enhanced cutaneous wound healing by functional injectable thermo-sensitive chitosan-based hydrogel encapsulated human umbilical cord-mesenchymal stem cells. International Journal of Biological Macromolecules. 2019, 137:433-441.

25.     Yang Xiang, Xiaohui Duan, Longbao Feng, Shuqi Jiang, Li Deng, Jun Shen*, Yijun Yang*, Rui Guo*. tLyp-1-conjugated GSH-sensitive biodegradable micelles mediate enhanced pUNO1-hTRAILa/curcumin co-delivery to gliomas. Chemical Engineering Journal. 2019, 374:392-404.

26.     Wu Zhang, Yuanyuan Zheng, Haixia Liu, Xiao Zhu, Yongchun Gu, Yong Lan, Jiali Tan, Hao Xu*, Rui Guo*. A non-invasive monitoring of USPIO labeled silk fibroin/hydroxyapatite scaffold loaded DPSCs for dental pulp regeneration. Materials Science and Engineering C. 2019, 103:109736. doi: 10.1016/j.msec.2019.05.021.

27.     Jianghui Liu, Liwei Yan, Wei Yang, Yong Lan, Qiyu Zhu, Hongjie Xu, Canbin Zheng*, Rui Guo*. Controlled-release neurotensin-loaded silk fibroin dressings improve wound healing in diabetic rat model. Bioactive Materials.2019, 4:151-159.

28.     Wei Yang, Yuanyuan Zheng, Jie Chen, Qiyu Zhu, Longbao Feng, Yong Lan, Ping Zhu, Shuo Tang*, Rui Guo*. Preparation and characterization of the collagen/cellulose nanocrystals/USPIO scaffolds loaded kartogenin for cartilage regeneration.Materials Science and Engineering C. 2019, 99:1362-1373.

29.     Wei Yang, Hongjie Xu, Yong Lan, Qiyu Zhu, Yu Liu, Shaoshan Huang, Shengjun Shi, Andrei Hancharou, Bing Tang, Rui Guo*. Preparation and characterisation of a novel silk fibroin/hyaluronic acid/sodium alginate scaffold for skin repair. International Journal of Biological Macromolecules.2019, 130:58-67.

30.     Lili Chen, Yuanyuan Zheng, Longbao Feng, Zonghua Liu, Rui Guo*, Yuanming Zhang*. Novel hyaluronic acid coated hydrophobically modified chitosan polyelectrolyte complex for the delivery of doxorubicin. International Journal of Biological Macromolecules. 2019, 126:254-261.

承担的部分科研项目：

1.2022年国家重点研发计划政府间国际科技创新合作重点专项（2022YFE0122200），免疫调控水凝胶调节巨噬细胞促进糖尿病创面修复与再生的研究，2023-01-01至2024-12-31，100万。（主持）

2.2022年国家重点研发计划（2022YFC2403100），基于重组人胶原蛋白的三维光刻通孔多梯度高仿生真皮支架研制，2022-11-01至2025-10-31，799万，课题二：重组人胶原及纤连蛋白的设计、合成与评价（2022YFC2403102），160万。（课题负责人）

3.2022年广东省国际科技合作领域项目（2022A0505050046），负载外泌体的功能化水凝胶促进慢性创面修复的研究，2022-01-01至2023-12-31，50万。（主持）

4.2022年广东省自然资源厅海洋经济专题（No. GDNRC[2022]039），基于海洋生物材料的创新医疗器械研发与产业化，2022-04-01至2024-03-30，300万。（主持）

5.2020年广东省自然资源厅海洋经济专题（No. GDNRC[2020]041），用于慢性创面的海藻多糖基高端敷料的开发，2020-01-15至2022-01-15，200万。（主持）

6.2019年广东省国际科技合作领域项目（2018A050506040），负载脐带间充质干细胞的抗感染水凝胶修复糖尿病创面的研究，2018-10-01至2020-10-01，100万。（主持）

1.中国专利，郭瑞，薛巍，冯龙宝，刘璇，一种谷胱甘肽响应型双载药物聚合物胶束及其制备方法与应用，授权，2020.3.17, CN201710271155.2

2.中国专利，郭瑞，冯龙宝，周莉明，一种负载抗菌肽的可自愈水凝胶创面敷料及其制备方法，授权，2023.2.3，CN202111342128.2

3.中国专利，薛巍，郭瑞，刘宗华，冯龙宝，一种抗菌水凝胶及其制备方法和应用，授权，2023.5.30，CN202210885532.2