个人信息

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姓名: 何庆瑜

部门: 生命科学技术学院

直属机构: 生命科学技术学院

性别:

职务: 生命科学技术学院 院长

职称: 教授

学位: Ph.D.

毕业院校: University of Sheffield

联系电话: 02085227039

电子邮箱: tqyhe@email.jnu.edu.cn

办公地址: 暨南大学第二理工楼912

通讯地址:

邮编: 510632

传真:

荣誉奖励: 长江学者

联系方式

个人简介

何庆瑜博士,“长江学者”特聘教授,国家重点研发计划项目首席科学家。1995年获英国谢菲尔德大学(University of Sheffield)生物化学博士学位;曾任英国牛津大学(University of Oxford)访问学者,美国佛蒙特大学(University of Vermont)博士后及香港大学助理教授(研究)2006年回国内后被国家人事部、科技部等七部委评为“新世纪百千万人才工程”国家级人选;2008年入选“长江学者”特聘教授;2010年获国务院政府特殊津贴;2011年获得广东省“五一劳动奖章”。

近年来一直致力于生物化学和功能蛋白质组学领域的研究工作,在组学方法建立、感染和癌症相关蛋白质组学及抗肿瘤药物的作用机理等领域进行了系统的创新性研究。在国际期刊上发表SCI论文210余篇,被引用6800多次(截至201811月),h-index: 40;相关科研成果获得美国国家癌症研究院(NCI)及美国NewsRX的专文评介。出版专著《功能蛋白质研究》及参编6部著作。近年来主持国家自然科学基金、国家“973”及国家重点研发计划项目和课题10项。是新加坡卫生部科研基金(NMRC)及南非国家医学研究基金(MRC)的评审专家。

    现任暨南大学生命科学技术学院院长及生命与健康工程研究院院长,教授,博士生导师;兼任中山大学基础医学国家级实验教学示范中心教学指导委员会主任委员(2017- ),暨南大学基因工程药物国家工程研究中心副主任。是美国ASBMB会员,英国皇家化学会会士(Fellow, FRSC),中国蛋白质组学专业委员会副理事长和蛋白质专业委员会委员。


学习经历

1995: PhD, University of Sheffield, UK

1988: MSc, JinanUniversity/Sun Yat-Sen University, China

1985: BSc, Jinan University, China

工作经历

2005 – Present: Professor and Director, Jinan University, China

2002 – 2006: Assistant Professor (Research), University of Hong Kong, Hong Kong

1996 – 2002: Post Doc. - Research Associate - Research Assistant Professor, University of Vermont, USA

1991 – 1992: Visiting Scholar, University of Oxford, UK


研究方向

  • Disease Proteomics: Biomarker discovery and validation.

  • Drug Proteomics: Drug action mechanism and target discovery.


主要论文

Publications (216 in total, google cited:9727 times SCI cited :6845times)

  1. Yang J, Li B,He QY. “Significance of prohibitin domain family in tumorigenesis and its implication in cancer diagnosis and treatment.” Cell Death Dis. doi: 10.1038/s41419-018-0661-3. (IF = 5.965)

  2. Liu WT, Wang Y, Zhang J, Ye F, Huang XH, Li B, He QY. “A novel strategy of integrated microarray analysis identifies CENPA, CDK1 and CDC20 as a cluster of diagnostic biomarkers in lung adenocarcinoma.” Cancer Lett. doi:10.1016/j.canlet.2018.03.043. (IF = 6.375)

  3. Xu WW, Li B, Zhao JF, Yang JG, Li JQ, Tsao SW, He QY, Cheung ALM. “IGF2 induces CD133 expression in esophageal cancer cells to promote cancer stemness.” Cancer Lett.doi: 10.1016/j.canlet.2018.03.039. (IF = 6.375)

  4. Zhang J, Wang Y, Zhou Y, He QY. “Jolkinolide B induces apoptosis of colorectal carcinoma through ROS-ER stress-Ca2+-mitochondria dependent pathway.” Oncotarget. doi: 10.18632/oncotarget.20077. (IF = 5.168)

  5. Zhong Y, Yang J, Xu WW, Wang Y, Zheng CC, Li B, He QY. “KCTD12 promotes tumorigenesis by facilitating CDC25B/CDK1/Aurora A-dependent G2/M transition.” Oncogene. doi: 10.1038/onc.2017.287. (IF = 7.519)

  6. Zhang J, Lu SH, Zhou Y, Meng K, Chen ZP, Cui YZ, Shi YF, Wang T, He QY. “Motile hepatocellular carcinoma cells preferentially secret sugar metabolism regulatory proteins via exosomes.” Proteomics. doi: 10.1002/pmic.201700103. (IF = 4.041)

  7. Wang Y, Zhang J, Huang ZH, Huang XH, Zheng WB, Yin XF, Li YL, Li B, He QY. “Isodeoxyelephantopin induces protective autophagy in lung cancer cells via Nrf2-p62-keap1 feedback loop.” Cell Death Dis. doi: 10.1038/cddis.2017.265. (IF = 5.965)

  8. Li B, Xu WW, Lam AKY, Wang Y, Hu HF, Guan XY, Qin YR, Saremi N, Tsao SW, He QY, Cheung ALM. “Significance of PI3K/AKT signaling pathway in metastasis of esophageal squamous cell carcinoma and its potential as a target for anti-metastasis therapy.”Oncotarget. doi: 10.18632/oncotarget.16333. (IF = 5.168)

  9. Li B, Xu WW, Han L, Chan KT, Tsao SW, Lee NP, Law S, Xu LY, Li EM, Chan KW, Qin YR, Guan XY, He QY, Cheung AL. “MicroRNA-377 suppresses initiation and progression of esophageal cancer by inhibiting CD133 and VEGF.” Oncogene. doi: 10.1038/onc.2017.29. ( IF = 7.519)

  10. Xu WW, Li B, Guan XY, Chung SK, Wang Y, Yip YL, Law SY, Chan KT, Lee NP, Chan KW, Xu LY, Li EM, Tsao SW, He QY, Cheung AL. “Cancer cell-secreted IGF2 instigates fibroblasts and bone marrow-derived vascular progenitor cells to promote cancer progression.” Nat Commun. doi: 10.1038/ncomms14399. (IF = 12.124)

  11. Gao XJ, Feng JX, He YJ, Xu FM, Fan XQ, Huang WS, Xiong HT, Liu QY, Liu WT, Liu XH, Sun XS, He QY, Zhang QH, Liu LX. “hnRNPK inhibits GSK3beta Ser9 phosphorylation, thereby stabilizing c-FLIP and contributes to TRAIL resistance in H1299 lung adenocarcinoma cells.” Sci Rep. doi: 10.1038/srep22999. (IF = 4.259)

  12. Li B, Xu WW, Guan XY, Qin YR, Law S, Lee NP, Chan KT, Tam PY, Li YY, Chan KW, Yuen HF, Tsao SW, He QY, Cheung AL. “Competitive Binding Between Id1 and E2F1 to Cdc20 Regulates E2F1 Degradation and Thymidylate Synthase Expression to Promote Esophageal Cancer Chemoresistance.” Clin Cancer Res. doi: 10.1158/1078-0432.CCR-15-1196. (IF = 9.619)

  13. Lian XL, Guo JH, Gu W, Cui YZ, Zhong JY, Jin JJ, He QY, Wang T, Zhang G. “Genome-Wide and Experimental Resolution of Relative Translation Elongation Speed at Individual Gene Level in Human Cells.” PLoS Genet. doi: 10.1371/journal.pgen.1005901. (IF = 6.1)

  14. Yang XY, He K, Du GF, Wu XH, Yu GC, Pan YL, Zhang G, Sun XS, He QY. “Integrated Translatomics with Proteomics to Identify Novel Iron-Transporting Proteins in Streptococcus pneumoniae.” Front Microbiol. doi: 10.3389/fmicb.2016.00078. (IF = 4.076)

  15. Chen ZP, Yang LJ, Cui YZ, Zhou YL, Yin XF, Guo JH, Zhang G, Wang T, He QY. “Cytoskeleton-centric protein transportation by exosomes transforms tumor-favorable macrophages.” Oncotarget. doi: 10.18632/oncotarget.11794. (IF = 5.168)

  16. Zhong J, Xiao C, Gu W, Du G, Sun X, He QY, Zhang G. “Transfer RNAs Mediate the Rapid Adaptation of Escherichia coli to Oxidative Stress.” PLoS Genet. doi: 10.1371/journal.pgen.1005302. (IF = 6.1)

  17. Yu G, Wang LG, He QY. “ChIPseeker: an R/Bioconductor package for ChIP peak annotation, comparison and visualization.” Bioinformatics. doi: 10.1093/bioinformatics/btv145. (IF = 7.307)

  18. Yu G, Wang LG, Yan GR, He QY. “DOSE: an R/Bioconductor package for disease ontology semantic and enrichment analysis.” Bioinformatics. doi: 10.1093/bioinformatics/btu684. (IF = 7.307)

  19. Li B, Tsao SW, Chan KW, Ludwig DL, Novosyadlyy R, Li YY, He QY, Cheung AL. “Id1-Induced IGF-II and Its Autocrine/Endocrine Promotion of Esophageal Cancer Progression and Chemoresistance-Implications for IGF-II and IGF-IR-Targeted Therapy.” Clin Cancer Res. doi:10.1158/1078-0432.CCR-13-2735. (IF = 9.619)

  20. Wang T, Cui Y, Jin J, Guo J, Wang G, Yin X, He QY, Zhang G. “Translating mRNAs strongly correlate to proteins in a multivariate manner and their translation ratios are phenotype specific.” Nucleic Acids Res. 2013 May;41(9):4743-54. doi: 10.1093/nar/gkt178. (IF = 10.162)


主要著作

承担课题

  1. 蛋白质修饰组的高维度鉴定及其功能网络,国家重点研发计划重点专项项目(2017YFA0505100),3124万元,2017/7-2022/6,主持。

  2. 细胞周期调节因子KCTD12的发现及其调控机制,国家自然科学基金面上项目(31770888),60万元,2018/1-2021/12,主持。

  3. 人类新蛋白UBAP1-AST6的发现及其功能研究,国家自然科学基金面上项目(31570828),62万元,2016/1-2019/12/1,主持。

  4. 功能蛋白质研究与抗癌药物靶标发现,广东省自然科学基金团队项目(S2013030013315),200万元,2013/10/1-2018/10/1,主持。


发明专利

讲授课程

荣誉奖励

长江学者

社会职务