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姓名: 李达伟 部门: 生命科学技术学院 性别: 男 职务: 教师 职称: 副研究员(自然科学) 学位: 博士 毕业院校: 暨南大学 联系电话: 电子邮箱: daweili@jnu.edu.cn 办公地址: 暨南大学生命科学技术学院B527 通讯地址: 暨南大学生命科学技术学院B525 邮编: 510632 传真: 荣誉奖励: |
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个人简介2019 年起就职于暨南大学生物工程学系教学科研岗(第五层次人才引进),曾担任生物工程学系研究生第二支部书记,主要从事微藻毒素合成、脂质代谢的分子机制等方面的研究工作。先后主持国家重点研发计划(子课题)、国家青年科学基金、广东省自然科学基金和中国博士后科学基金等项目。在微藻基因功能研究与表观调控领域发表SCI论文50篇,其中以通讯作者或第一作者(含共同)发表15篇。以第一作者身份在Science子刊 Science Advances(IF=14.136)上发表了关于表观调控的研究成果,并获得5项国家发明专利授权。此外,受邀担任国际权威期刊《Renewable Energy》(一区TOP,IF=9)特刊主编及《Environmental Research》和《Algal Research》等的客座编辑;于2019年获得中国海洋湖沼学会颁发的“中国藻类学研究优秀论文奖”二等奖,同年入选广东省100位博士博士后创新人物。 学习经历2011.09至2016.07, 暨南大学, 生命科学技术学院, 博士(硕博连读) 2007.09至2011.07, 广西民族大学,本科 工作经历2019.09-至今, 暨南大学, 生科院生物工程学系, 副研究员 2016.08-2019.09, 暨南大学, 生科院生态系, 博士后 研究方向(1)甲藻毒素合成和毒素表观调控分子机制 (2)合成生物学(基于酵母合成神经酸、紫杉醇等) (3)微藻脂质代谢机理 (4)生物信息学 主要论文通讯或者一作(*通讯,#共同贡献) (1) Li, D.-W.#, Balamurugan, S. #, Yang, Y.-F., Zheng, J.-W., Huang, D., Zou, L.-G., Yang, W.-D., Liu, J.-S., Guan, Y., Li, H.-Y.* Transcriptional regulation of microalgae for concurrent lipid overproduction and secretion. Science Advances,2019, eaau3795. (2) Huang, Xue-ling; Xu, Zhen-Hao; Qiu, Jiang-Bing; Ou, Xiao-Li ; Yu, Shuang; Zhang, Hao-Yun ; Huang, Dan; Wu, Si-Wei; Huang, Yi-Tong; Zou, Li-Gong; Yang, Wei-Dong; Li, Hong-Ye; Ou, Lin-Jian; Li, Da-Wei. Understanding the molecular mechanisms of pyrene in governing critical metabolic circuits of Alexandrium pacificum. Environmental Science & Technology, 2025(Accepted) (3) Huang, D., Cheng, C.-Q., Qiu, J.-B., Huang, Y., Zhang, H.-Y., Xu, Z.-H., Wu, S.-W., Huang, Y.-T., Chen, J., Zou, L.-G., Yang, W.D. Li, H.Y., Li, D.W*, Mechanistic insights into the effects of diuron exposure on Alexandrium pacificum.Water Research,2024, 120987. (4) Wu, S.-W., Cheng, C.Q., Huang, Y.T., Tan, J.Z., Li, S.L., Yang, J.X., Huang, X.L., Huang, D., Zou, L.G., Yang, W.D. Li, H.Y., Li, D.W*, A study on the mechanism of the impact of phenthoate exposure on Prorocentrum lima. Journal of Hazardous Materials,2024, 132624. (5) Feng, N.-X. #, Li, D.-W. #, Zhang, F., Bin, H., Huang, Y.-T., Xiang, L., Liu, B.-L., Cai, Q.-Y., Li, Y.-W., Xu, D.-L., Xie, Y.-C*, Mo, C.-H*. Biodegradation of phthalate acid esters and whole-genome analysis of a novel Streptomyces sp. FZ201 isolated from natural habitats. Journal of Hazardous Materials, 2024, 469, 133972. (6) Huang, X.-L., Zhuang, Y.-Q., Xiong, Y.-Y., Li, D.-W. *, Ou, L.-J*. Efficient modulation of cellular phosphorus components in response to phosphorus deficiency in the dinoflagellate Karenia mikimotoi. Applied and Environmental Microbiology,2023, e00867-23. (7) Chen, X.-W., Chen, H., Zhao, H.-L., Li, D.-W.*, Ou, L.-J*. Triazine herbicide reduced the toxicity of the harmful dinoflagellate Karenia mikimotoi by impairing its photosynthetic systems. Ecotoxicology and Environmental Safety, 2024, 269, 115740 (8) Tang, J.-Q., Shen, Q.-H., Han, Y.-Y., Wu, Y., He, X.-F., Li, D.-W.*, Huang, Y*. Analysis of research status and trends on marine benthic dinoflagellate toxins: A bibliometric study based on web of science database and VOSviewer. Environmental Research, 2023, 117179. (9) Li, D.-W., Balamurugan, S., Zheng, J.-W., Yang, W.-D., Liu, J.-S., Li, H.-Y.* Rapid and effective electroporation protocol for Nannochloropsis oceanica. Methods in Molecular Biology (Clifton, N.J.), 2020, pp. 175-179. (10) Li, D.W. #, Cen, S.Y. #, Liu, Y.H., Balamurugan, S., Zheng, X.Y., Alimujiang, A., Yang, W.D., Liu, J.S., Li, H.Y.* A type 2 diacylglycerol acyltransferase accelerates the triacylglycerol biosynthesis in heterokont oleaginous microalga Nannochloropsis oceanica. Journal of Biotechnology, 2016,229, 65-71. (11)Li, L., Chen, S., Xu, S.Y., Li, D.W.*, Li, H.Y., Yang, W.D.* , Toxicity and underlying mechanism of the toxic dinoflagellate Gambierdiscus caribaeus to the fish Oryzias melastigma. Ecotoxicology and Environmental Safety, 2022, 247, 114223. (12)Cen, S.Y. #, Li, D.W. #, Huang, X.L., Huang, D., Balamurugan, S., Liu, W.J., Zheng, J.W., Yang, W.D., Li, H.Y. Crucial carotenogenic genes elevate hyperaccumulation of both fucoxanthin and β-carotene in Phaeodactylum tricornutum. Algal Research, 2022, 64, 102691. (13)Yang, Y.F. #, Li, D.W. #, Chen, T.T., Hao, T.B., Balamurugan, S., Yang, W.D., Liu, J.S., Li, H.Y.* Overproduction of bioactive algal chrysolaminarin by the critical carbon flux regulator phosphoglucomutase. Biotechnology Journal,2018,1800220. (14)Zheng, J.W. #, Li, D.W. #, Lu, Y., Chen, J., Liang, J.J., Zhang, L., Yang, W.D., Liu, J.S., Lu, S.H., Li, H.Y.* Molecular exploration of algal interaction between the diatom Phaeodactylum tricornutum and the dinoflagellate Alexandrium tamarense. Algal Research, 2016, 17, 132-141. 主要著作承担课题1.国家重点研发计划子课题负责人,2019.1-2021.12,主持,已结题。 2.国家青年科学基金,2022.1-2024.12,主持,在研。 3.广东省基础与应用基础研究基金自然科学基金面上项目,2021.1-2023.12,主持,在研。 4.广东省基础与应用基础研究基金联合基金青年基金项目,2020.1-2022.12,主持,结题。 5.暨南大学人才引进项目,2019.05-2022.05,主持,在研。 6.中国博士后科学基金面上资助, 2017.05-2019.05,主持,已结题。 发明专利(1)李达伟;李宏业等,一种微藻类外泌体、其制备方法和应用,2022-11-19,中国,公开号:CN115992052A (2)李达伟;李宏业等,基因终止子查询方法、装置、设备及可读存储介质,2023-05-08,中国,申请号:202310511302.4 (3)李宏业;李达伟等;一种物种基因组的启动子查询方法、系统及设备,2021-9-15,中国,ZL202110822106.X (4)李宏业; 李达伟; 杨维东; 刘洁生; 一种DNA序列及其应用, 2017-2-21, 中国, ZL201710092923.8. (5)李宏业; 李达伟; 杨维东; 刘洁生; 一种干扰基因及其应用, 2017-2-21, 中国, ZL201710093488.0. 讲授课程(1)合成生物学 (2)动物生理学实验 (3)生产实习 荣誉奖励社会职务(1)Renewable Energy特刊主编(JCR一区),2nd July 2024 - Present (2)Chemosphere,客座编辑,1st January 2022 (3)Algal Research客座编辑,1st January 2022 (4)Environmental Research客座编辑,1st August 2023 - 31st July 2024 (5)Environmental Research客座编辑,1st January 2022 - 1st January 2023 (6)担任International Journal of Biological Macromolecules 杂志审稿人。 |