个人信息

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姓名: 刘朗夏

部门: 生命科学技术学院

直属机构: 生化与分子生物学系(生命与健康工程研究院)

性别:

职务:

职称: 教授

学位: 博士

毕业院校: 巴黎第七大学

联系电话: 15918537920

电子邮箱: langxialiu@gmail.com

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个人简介

在广州暨南大学获得生物学学士学位,在法国巴黎第六和巴黎第七大学相继取得生物化学学士学位,细胞与分子生物学硕士学位和分子微生物学博士学位(1998年)。1999年至2001年在法国国家健康与医学研究院进行博士后研究。2001年至2007年间在巴黎血管与血液研究所及法国国家健康与医学研究院担任研究员。从20087月起被暨南大学聘为教授,博导,为广东省高校“千百十”人才工程省级培养对象。

    多年来致力于蛋白质相互作用鉴定及其功能方面的研究,研究领域涉及蛋白质之间的相互作用及其功能、癌症、破骨细胞分化、病原微生物致病等过程的分子机制。在SCI著名期刊(Journal of Biological Chemistry, Journal of Molecular Biology, Scientific Reports, Journal of Virology, Retrovirology)上发表SCI收录论文近30篇,文章被引用总数超1400次(截止201812月)。近年来承担国家重点基础研究发展计划“973”子项目、广东省自然科学基金等项目。是欧盟框架计划研究基金子项目、法国国家艾滋病研究学会(ANRS)奖学金及欧洲脑白质失养症研究协会研究基金的获得者,中法科学技术促进协会的成员。曾担任国家自然科学基金面上项目和青年项目、广东省自然科学基金杰青项目和一般项目的评审委员,多种市级项目的评审专家,是J. Biol. Chem.Scientific Reports, J. Cell. BioChem., J. Cell. Physiol., Viruses等国际期刊的审稿人。

学习经历

学士: 1988, 暨南大学

学士: 1992, 巴黎第七大学(狄德罗大学),法国

硕士: 1994, 巴黎第六大学(皮埃尔和玛丽居里大学),法国

博士: 1998, 巴黎第七大学(狄德罗大学),法国

工作经历

1999-2001:博士后研究员,法国国立健康与医学研究院342研究单位

2001-2004:研究员,法国巴黎血管与血液研究所


2004-2007:研究员,法国国立健康与医学研究院(Cochin研究所)传染病部

2008 至今,教授, 博导,暨南大学生命科学技术学院


研究方向

癌症发病分子机理

细胞信号通路

破骨细胞分化机制

病原微生物致病机理

蛋白质相互作用及功能

主要论文

  1. Liu Xiaohui, Ma Jie, Feng Junxia, Zhang Yunfang*, Liu Langxia*. Regulation and related mechanism of GSN mRNA level by hnRNPK in lung adenocarcinoma cells. Biol. Chem. 2018. doi:10.1515/hsz-2018-0417.

  2. Li Zhipeng, Liu Xiaohui*, Ma Jie, Zhang Tingting, Gao Xuejuan, Liu Langxia*. hnRNPK modulates selective quality-control autophagy by downregulating the expression of HDAC6 in 293 cells. Int. J. Oncol. 2018, 53:2200-12.

  3. Wang Cuihua, Chen Kezhi, Liao Shengyou, Gu Wei, Lian Xinlei, Zhang Jing, Gao Xuejuan, Liu Xiaohui, Wang Tong, He Qingyu, Zhang Gong, Liu Langxia*. The flightless I protein interacts with RNA-binding proteins and is involved in the genome-wide mRNA post-transcriptional regulation in lung carcinoma cells. Int. J. Oncol. 2017, 51:347-61.

  4. Lu Wen-hui, Shi Yu-xun, Ma Zheng-lai, Wang Guang, Liu Langxia, Chuai Manli, Song Xiaoyu, Münsterberg Andrea, Cao Liu, Yang Xuesong. Proper autophagy is indispensable for angiogenesis during chick embryo development. Cell Cycle 2016, 15:1742-54.

  5. Gao Xuejuan, Xu Fengmei, Zhang Huan-Tian, Chen Miaojuan, Huang Wensi, Zhang Qihao, Zeng Qingzhong, Liu Langxia*. PKCα–GSK3β–NF-κB signaling pathway and the possible involvement of TRIM21 in TRAIL-induced apoptosis. Biochem. Cell Biol. 2016, 94:256-64.

  6. Gao Xuejuan, Feng Junxia, He Yujiao, Xu Fengmei, Fan Xiaoqin, Huang Wensi, Xiong Haiting, Liu Qiuyu, Liu Wanting, Liu Xiaohui, Sun Xuesong, He Qing-Yu, Zhang Qihao*, Liu Langxia*. hnRNPK inhibits GSK3β Ser9 phosphorylation, thereby stabilizing c-FLIP and contributes to TRAIL resistance in H1299 lung adenocarcinoma cells. Sci. Rep. 2016, 6:22999-99.

  7. Fan Xiaoqin, Xiong Haiting, Wei Jinmei, Gao Xuejuan, Feng Yuan, Liu Xiaohui, Zhang Gong, He Qingyu*, Xu Jiake*, Liu Langxia*. Cytoplasmic hnRNPK interacts with GSK3β and is essential for the osteoclast differentiation. Sci. Rep. 2016, 5:17732-32.

  8. Wang Cuihua, Gao Xuejuan, Liao Shengyou, Feng Junxia, Luo Bin, Liu Langxia*. Transcriptome analysis of human breast cancer cell lines MCF-7 and MDA-MB- 435 by RNA-seq. Mol. Biol. 2015, 49:244-52.

  9. Gao Xuejuan, Dan Songsong, Xie Yingying, Qin Huanhuan, Tang Donge, Liu Xiaohui, He Qingyu, Liu Langxia*. 1433ζ Reduces DNA Damage by Interacting With and Stabilizing Proliferating Cell Nuclear Antigen. J. Cell. Biochem. 2015, 116:158-69.

  10. Fan Xiaoqin, Wei Jinmei, Xiong Haiting, Liu Xiaohui, Benichou Serge, Gao Xuejuan*, Liu Langxia*. A homogeneous time-resolved fluorescence-based high-throughput screening for discovery of inhibitors of Nef-sdAb19 interaction. Int. J. Oncol. 2015, 47:1485-93.

  11. Li Nan, Yang Xiao-Yan, Guo Zhong, Zhang Jing, Cao Kun, Han Junlong, Zhang Gong, Liu Langxia, Sun Xuesong, He Qing-Yu. Varied metal-binding properties of lipoprotein PsaA in Streptococcus pneumoniae. JBIC. 2014, 19:829-38.

  12. Gao Xue Juan, Feng Jun Xia, Zhu Sen, Liu Xiao Hui, Tardieux Isabelle, Liu Langxia*. Protein Phosphatase 2C of Toxoplasma Gondii Interacts with Human SSRP1 and Negatively Regulates Cell Apoptosis. Biomed. Environ. Sci. 2014, 27:883-93.

  13. Gao Xuejuan, He Yujiao, Gao Lingmei, Feng Junxia, Xie Yingying, Liu Xiaohui, Liu Langxia*. Ser9-phosphorylated GSK3β induced by 14-3-3ζ actively antagonizes cell apoptosis in a NF-κB dependent manner. Biochem. Cell Biol. 2014, 92:349-56.

  14. Chen Miaojuan, Liu Tengfei, Xu Lina, Gao Xuejuan, Liu Xiaohui, Wang Cuihua, He Qingyu, Zhang Gong, Liu Langxia*. Direct Interaction of 14-3-3ζ with Ezrin Promotes Cell Migration by Regulating the Formation of Membrane Ruffle. J. Mol. Biol. 2014, 426:3118-33.

  15. Chen Miaojuan, Gao Xuejuan, Xu Lina, Liu Tengfei, Liu Xiaohui, Liu Langxia*. Ezrin is required for epithelial-mesenchymal transition induced by TGF-β1 in A549 cells. Int. J. Oncol. 2014, 45:1515-22.

  16. Gao Xuejuan, Wang Jianying, Gao Lingmei, Yin Xingfeng, Liu Langxia*. Identification and analysis of glycogen synthase kinase 3 beta1 interactome. Cell Biol. Int. 2013, 37:768-79.

  17. Yan Guangrong, Xu Songhui, Tan Zilu, Liu Langxia, He Qingyu. Global identification of miR373regulated genes in breast cancer by quantitative proteomics. Proteomics 2011, 11:912-20.

  18. Li Liping, Lu Chunhua, Chen Zhipeng, Ge Feng, Wang Tong, Wang Wei, Xiao ChuanlLe, Yin Xinfeng, Liu Langxia, He Jianxing. Subcellular proteomics revealed the epithelialmesenchymal transition phenotype in lung cancer. Proteomics 2011, 11:429-39.

  19. Lemay Julie, Maidoupeindara Priscilla, Cancio Reynel, Ennifar Eric, Coadou Gael, Maga Giovanni, Rain Jeanchristophe, Benarous Richard, Liu Langxia*. AKAP149 Binds to HIV-1 Reverse Transcriptase and Is Involved in the Reverse Transcription. J. Mol. Biol. 2008, 383:783-96.

  20. Lemay Julie, Maidoupeindara Priscilla, Bader Thomas, Ennifar Eric, Rain Jeanchristophe, Benarous Richard, Liu Langxia*. HuR interacts with human immunodeficiency virus type 1 reverse transcriptase, and modulates reverse transcription in infected cells. Retrovirology 2008, 5:47-47.

  21. Hainaud Patricia, Contreres Jeanolivier, Villemain Aude, Liu Langxia, Plouet Jean, Tobelem Gerard, Dupuy Evelyne. The Role of the Vascular Endothelial Growth Factor–Delta-like 4 Ligand/Notch4-Ephrin B2 Cascade in Tumor Vessel Remodeling and Endothelial Cell Functions. Cancer Res. 2006, 66:8501-10.

  22. Liu Lang Xia, Heveker Nikolaus, Fackler Oliver T, Arold Stefan, Le Gall Sylvie, Janvier Katy, Peterlin B Matija, Dumas Christian, Schwartz Olivier, Benichou Serge. Mutation of a conserved residue (D123) required for oligomerization of human immunodeficiency virus type 1 Nef protein abolishes interaction with human thioesterase and results in impairment of Nef biological functions. J. Virol. 2000, 74:5310-19.

  23. Selig L, Pages J-C, Tanchou V, Preveral S, Berlioz-Torrent C, Liu Lang Xia, Erdtmann L, Darlix J-L, Benarous R, Benichou S. Interaction with the p6 domain of the gag precursor mediates incorporation into virions of Vpr and Vpx proteins from primate lentiviruses. J. Virol. 1999, 73:592-600.

  24. Liu Lang Xia, Janvier Katy, Berteaux-Lecellier Véronique, Cartier Nathalie, Benarous Richard, Aubourg Patrick. Homo-and heterodimerization of peroxisomal ATP-binding cassette half-transporters. J. Biol. Chem. 1999, 274:32738-43.

  25. Le Gall Sylvie, Erdtmann Lars, Benichou Serge, Berlioz-Torrent Clarisse, Liu Langxia, Benarous Richard, Heard Jean-Michel, Schwartz Olivier. Nef interacts with the μ subunit of clathrin adaptor complexes and reveals a cryptic sorting signal in MHC I molecules. Immunity 1998, 8:483-95.

  26. Liu Lang Xia, Margottin Florence, Le Gall Sylvie, Schwartz Olivier, Selig Luc, Benarous Richard, Benichou Serge. Binding of HIV-1 Nef to a novel thioesterase enzyme correlates with Nef-mediated CD4 down-regulation. J. Biol. Chem. 1997, 272:13779-85.

  27. Benichou S, Liu LangXia, Erdtmann L, Selig L, Benarous R. Use of the two-hybrid system to identify cellular partners of the HIV1 Nef protein. Res. Virol. 1997, 148:71-73.

  28. Margottin Florence, Benichou Serge, Durand Hervé, Richard Virginie, Liu Lang Xia, Gomas Emmanuel, Benarous Richard. Interaction between the Cytoplasmic Domains of HIV-1 Vpu and CD4: Role of Vpu Residues Involved in CD4 Interaction andin VitroCD4 Degradation. Virology 1996, 223:381-86.


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