个人信息

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姓名: 伍姝

部门: 生命科学技术学院

性别:

职务:

职称: 副研究员(自然科学)

学位:

毕业院校: 清华大学

联系电话: 020-85224362

电子邮箱: wushu@jnu.edu.cn

办公地址: 广州市天河区黄埔大道西601暨南大学第二理工楼839

通讯地址: 广州市天河区黄埔大道西601暨南大学第二理工楼847

邮编: 510632

传真:

荣誉奖励:

联系方式

地址:广州市天河区黄埔大道西601暨南大学第二理工楼839

邮编:510632

电子邮件:wushu@jnu.edu.cn


个人简介

生物学博士,副研究员。2015年毕业于清华大学获理学博士学位。研究工作主要聚焦于遗传信息在传递过程中的保真性调控,重点关注基因组稳定性调控、RNA结构与修饰在细胞衰老以及老年疾病中的作用研究。近五年主要研究成果以第一作者或通讯作者(含共同)发表在本领域TOP期刊Nucleic Acids ResearchProtein & CellPLoS Genetics,Journal of Biological Chemistry等杂志。主持国自然面上、青年2项国家级项目,以及广东省面上、校企横向等多项基金。

学习经历

工作经历

研究方向

1、基因组稳定性调控在细胞衰老及老年疾病中的作用研究。
2RNA结构与修饰在细胞衰老及老年疾病中的作用研究。


主要论文

1Quan Hu# *, Yanan Zhao#, Wanyang Sun#, Zexian Ou, Wentao Duan, Zeyu Qiu, Yuanlong Ge, Daolin Tang, Tianfeng Chen, Xiang Cheng, Rongrong He, Shu Wu*, Zhenyu Ju* (2024). CK-666 protects against ferroptosis and renal ischemia-reperfusion injury through a microfilament-independent mechanism. Journal of Biological Chemistry, 300(12), 10792. (TOP, IF2023=4.0)

2Fei Wen, Anhua Xu, Wenjing Wei, Shenglong Yang, Zhiliang Xi, Yuanlong Ge, Shu Wu*, Zhenyu Ju* (2024). Nicotinamide Mononucleotide Supplementation Alleviates Doxorubicin-Induced Multi-Organ Fibrosis. International Journal of Molecular Sciences, 25(10), 5303. (IF2023=4.9)

3Shu Wu#, Yuanlong Ge# *, Kaixuan Lin, Qianqian Liu, Haoxian Zhou, Qian Hu, Yong Zhao, Weifeng He*, Zhenyu Ju* (2022). Telomerase RNA TERC and the PI3K-AKT pathway form a positive feedback loop to regulate cell proliferation independent of telomerase activity. Nucleic Acids Research, 50(7): 3764-3776. (TOP, IF2022=14.9)

4、Shu Wu#Yuanlong Ge#,Xiaocui Li, Yiding Yang, Haoxian Zhou, Kaixuan Lin, Zepeng Zhang, Yong Zhao* (2020). BRM-SWI/SNF chromatin remodeling complex enables functional telomeres by promoting coexpression of TRF2 and TRF1.PLoS Genetics, 16(6): e1008799. (TOP, IF2020=5.917)

5Yuanlong Ge#, Shu Wu#, Zepeng Zhang, Xiaocui Li, Feng Li, Siyu Yan, Haiying Liu, Junjiu Huang, Yong Zhao* (2019). Inhibition of p53 and/or AKT as a New Therapeutic Approach Specifically Targeting ALT Cancers. Protein & Cell, 10(11): 808-824. (TOP, IF2019=10.16, 封面文章, Co-first author)

6Yuanlong Ge#, Shu Wu#, Yong Xue, Jun Tao, Feng Li, Yanlian Chen, Haiying Liu, Wenbin Ma, Junjiu Huang, Yong Zhao* (2016). Preferential extension of short telomeres induced by low extracellular pH. Nucleic Acids Research, 44(17), 8086-8096. (TOP, IF2016=10.162, Co-first author)

7、Shu Wu#, Yuanlong Ge#, Laiqiang Huang, Haiying Liu, Yong Xue, Yong Zhao* (2014). BRG1, the ATPase Subunit of SWI/SNF Chromatin Remodeling Complex, Interacts with HDAC2 to Modulate Telomerase in Human Cancer Cells. Cell Cycle, 13(18): 2869-2878. (IF2014=4.565)

8Ying Zou, Shu Wu, Qian Hu, Haoxian Zhou, Yuanlong Ge*, Zhenyu Ju*, Shengkang Luo* (2024). Sonic hedgehog restrains the ubiquitin-dependent degradation of SP1 to inhibit neuronal/glial senescence associated phenotypes in chemotherapy-induced peripheral neuropathy via the TRIM25-CXCL13 axis. Journal of Advanced Research. (In press)

9Ying Zou, Shu Wu, Fei Wen, Yuanlong Ge*, Shengkang Luo* (2023). PGC-1α Inhibits Schwann Cell Dedifferentiation and Delays Peripheral Nerve Degeneration by Targeting PON1. Cellular and Molecular Neurobiology, 43(7):3767-3781.

10Xiaocui Li, Xiaojuan Li, Chen Xie, Sihui Cai, Mengqiu Li, Heping Jin, Shu Wu, Jun Cui, Haiying Liu*, Yong Zhao (2022). cGAS guards against chromosome end-to-end fusions during mitosis and facilitates replicative senescence. Protein & Cell, 13(1): 47-64.

11Juanhong Liu#, Yuanlong Ge#, Shu Wu, Delin Ma, Weijie Xu, Ye Zhang, and Yan Yang* (2019). Association between antidiabetic agents use and leukocyte telomere shortening rates in patients with type 2 diabetes. Aging-US, 11(2): 741-755.

12Yi Zheng#, Yicheng Yang#, Shu Wu, Yongqiang Zhu, Xiaolong Tang, Xiaopeng Liu (2017). Combining MPDL3280A with adoptive cell immunotherapy exerts better antitumor effects against cervical cancer. Bioengineered, 8(4): 367-373.

13Yongqiang Zhu, Yi Zheng, Lin Mei, Mengqiong Liu, Shanshan Li, Huawei Xiao, Huijun Zhu, Shu Wu, Hongbo Chen, Laiqiang Huang*(2013). Enhanced immunotherapeutic effect of modified HPV16 E7-pulsed dendritic cell vaccine by an adeno-shRNA-SOCS1 virus. Int J Oncol, 43(4): 1151-1159.

14Bo Qiu#, Minghui Ji#, Xiaosong Song, Yongqiang Zhu, Zhongyuan Wang, Xudong Zhang, Shu Wu, Hongbo Chen, Lin Mei*, Yi Zheng* (2012). Co-delivery of docetaxel and endostatin by a biodegradable nanoparticle for the synergistic treatment of cervical cancer. Nanoscale Research Letters, 7(1):666.




主要著作

承担课题

1、国家自然科学基金面上项目,822715902023/01-2026/12,主持。

2、国家自然科学基金重点项目,22338004,2024/01-2028/12,骨干成员。

3、国家自然科学基金青年科学基金,317011962018/01-2020/12,主持。

4、广东省基础与应用基础研究基金自然科学基金,2024A15150107272024/01-2026/12,主持。

5、广东省基础与应用基础研究基金自然科学基金,2020A151501155222019/10-2022/9,主持。

6、高校基本科研业务费青年教师培育项目,18lgpy522018/01-2020/12,主持。

7、中国博士后科学基金面上资助(一等),2016M600696,主持。

8、校企合作—内蒙古金达威药业有限公司,2022/03-2024/2,主持。

发明专利

1、赵勇,葛远龙,伍姝P53转录抑制剂PFTαHBr在制备抗端粒酶阴性p53阳性肿瘤药物中的应用。授权公布号:ZL201810797534.X。

2、葛远龙,伍姝,鞠振宇,许婉尔,梁凯欣,陶丽。一种 CD38 蛋白抑制剂及其筛选方法和在抗衰老中的应用。申请号:202311670625.4



讲授课程

研究生课程:《衰老生物学》

本科生课程:《肿瘤分子生物学》


荣誉奖励

社会职务