博士生导师，广东省生理学会副理事长，广东省高等学校生物类教学指导委员会副主任委员。主要从事赤潮毒素对人类健康的危害、环境生物对赤潮毒素的响应与解毒机制等的研究。主持国家重点研发计划项目、国家自然科学基金面上项目等多项，以通讯作者身份发表SCI论文50余篇，授权专利6项。获教育部高等学校科学研究优秀成果奖（科学技术）二等奖1项。主编和参编教材各一部，参与国家金课建设3门，获广东省教育教学成果一等奖2项，二等奖1项。多次担任广东省杰出青年基金会评专家以及全国大学生生命科学竞赛、广东省大学生生物化学实验技能大赛等学科竞赛评委等。

1989年 本科毕业于西北师范大学化学系

1992年 在西北师范大学化学系获得理学硕士学位

1999年 在中山大学化学化工学院获得理学博士学位

1992-1996 在兰州大学药学院（原兰州医学院药学系）任教

1999年 入职暨南大学生命科学技术学院，先后任讲师、副教授（2000）、教授（2006）。

1. 赤潮毒素与人类健康

2. 赤潮毒素与水产品安全

3. 水生态毒理学

[1]             Jin-jin Lv, Yu-jie Liu, Yan-hang Mo, Li-yan Deng, Yang Liu, Hong-ye Li, Li Zhang*, Wei-dong Yang*, 2025. The tolerance mechanism of diarrhetic shellfish toxins mediated by the extracellular regulated protein kinase (ERK) pathway in the mussel Perna viridis. J. Hazard. Mater. 484, 138006.

[2]             Kuan-Kuan Yuan, Ying-Ying Yu, Yu-Jie Liu, Xiu-Lin Yang, Yan-Hang Mo, Wei Shi, Guang-Xu Liu*, Hong-Ye Li, Wei-Dong Yang*, 2025. Microplastics-exposure experience aggravates the accumulation of diarrhetic shellfish toxins (DSTs) in thick-shell mussel Mytilus coruscus through impairing detoxification processes. J. Hazard. Mater.484, 136782.https://doi.org/10.1016/j.jhazmat.2024.136782

[3]             Kuan-Kuan Yuan, Ya-Xin Liu, Xiu-Lin Yang, Yu-Jie Liu, Hong-Ye Li, Wei-Dong Yang*, 2025. Responses of nuclear receptor HR96 to the toxic dinoflagellate Prorocentrum lima in Crassostrea ariakensis. Ecotoxicol. Environ. Saf. 292, 117909.

[4]             Hong-Jia Huang, Yang Liu, Da-wei Li, Xiang Wang, Nai-xian Feng, Hong-Ye Li, Ce-hui Mo*, Wei-Dong Yang*, 2025. Polystyrene microplastics can aggravate the damage of the intestinal microenvironment caused by okadaic acid: a prevalent algal toxin. Mar. Drugs 23, 129. https://doi.org/ 10.3390/md23030129

[5]             Kuan-Kuan Yuan, Hong-Ye Li, Wei-Dong Yang*, 2024. Marine algal toxins and public health: Insights from shellfish and fish, the main biological vectors. Mar. Drugs 22, 510. https://doi.org/ 10.3390/md22110510

[6]             Hong-Jia Huang, Yang Liu, Xiang Wang, Lu Huang, Da-wei Li, Hong-Ye Li, Wei-Dong Yang*, 2024. Polystyrene microplastics exacerbated the toxicity of okadaic acid to the small intestine in mice. Ecotoxicol. Environ. Saf. 281, 116628 https://doi.org/10.1016/j.ecoenv.2024.116628

[7]             Si-Yuan Xu, Yan-Hang Mo, Yu-Jie Liu, Xiang Wang, Hong-Ye Li, Wei-Dong Yang*, 2024.Physiological and genetic responses of the benthic dinoflagellate Prorocentrum lima to polystyrene microplastics. Harmful Algae 136, 102652.https://doi.org/10.1016/j.hal.2024.102652

[8]             Kuan-Kuan Yuan, Ying-Ying Yu, Yan-Hang Mo, Yu-Jie Liu, Wei-Xia Zhang, Jin-Jin Lv, Wei Shi, Guang-Xu Liu*,Hong-Ye Li, Wei-Dong Yang*, 2024. Exposure to microplastics renders immunity of the thick-shell mussel more vulnerable to diarrhetic shellfish toxin-producing harmful algae. Sci. Total Environ. 926, 172125.https://doi.org/10.1016/j.scitotenv.2024.172125

[9]             Qin-yuan Liu, Zi-min Chen, Da-wei Li, Ai-feng Li, Ying Ji, Hong-ye Li, Wei-dong Yang*, 2023. Toxicity and potential underlying mechanism of Karenia selliformis to the fish Oryzias melastigma. Aquat. Toxicol. 262, 106643. https://doi.org/10.1016/j.aquatox.2023.106643

[10]         Yang Liu, Tian-Qing Yuan, Jian-Wei Zheng, Da-Wei Li, Yu-Hu Jiao, Hong-Ye Li, Rui-Man Li*, Wei-Dong Yang, 2023. Exposure to okadaic acid could disrupt the colonic microenvironment in rats. Ecotoxicol. Environ. Saf. 263, 115376. https://doi.org/10.1016/j.ecoenv.2023.115376

[11]         Jian-Wei Zheng, Guo-Hui He, Rui-Xia Xu, Xiang Wang, Hong-Ye Li, Wei-Dong Yang, 2023. Systematic exploration of transcriptional responses of interspecies interaction between Karenia mikimotoi and Prorocentrum shikokuense. Harmful Algae 126, 102441. https://doi.org/10.1016/j.hal.2023.102441

[12]         Yang Liu, Chun-Li Qi, Da-Wei Li, Hong-Ye Li, Rui-Man Li*, Wei-Dong Yang*, 2023. Microcystin-LR exposure interfered maintenance of colonic microenvironmental homeostasis in rat. Food Chem. Toxicol. 173, 113611https://doi.org/10.1016/j.fct.2023.113611

[13]         Kuan-Kuan Yuan, Zi-Min Chen, Ya-Xin Liu, Hong-Ye Li, Wei-Dong Yang*, 2023. Possible role of docosahexaenoic acid in response to diarrhetic shellfish toxins in the mussel Perna viridis. Mar. Drugs 21, 155. https://doi.org/10.3390/md21030155

[14]         Jin-Jin Lv, Kuan-Kuan Yuan, Guan-Xiu Lu, Hong-Ye Li,Hang Fai Kwok, Wei-dong Yang*, 2023. Responses of ABCB and ABCC transporters to the toxic dinoflagellate Prorocentrum lima in the mussel Perna viridis.Aquat. Toxicol. 254, 106368.doi:10.1016/j.aquatox.2022.106368

[15]         Zhihui Cai, Yutian Zhang, Zhang Weijie Zhang, Jinmin Ye, Qinjie Ling, Zhi Xing, Sichun Zhang, Peter R. Hoffmann, Youbin Liu, Weidong Yang, Zhi Huang, 2022. Arsenic retention in erythrocytes and excessive erythrophagocytosis is related to low selenium status by impaired redox homeostasis. Redox Biology 52, 102321 DOI: 10.1016/j.redox.2022.102321

[16]         Li Li, Shuang Chen, Si-yuan Xu, Da-wei Li*, Hong-ye Li, Wei-dong Yang*, 2022.Toxicity and underlying mechanism of the toxic dinoflagellate Gambierdiscuscaribaeus tothe fish Oryzias melastigma. Ecotoxicol. Environ. Saf. 247, 114223. https://doi.org/10.1016/j.ecoenv.2022.114223

[17]         Yang Liu, Si-Yuan Xu, Qiu-Die Cai, Da-Wei Li, Hong-Ye Li, Wei-Dong Yang*, 2022. In vitro interactions between okadaic acid and rat gut microbiome. Mar. Drugs 20, 556. https://doi.org/10.3390/md20090556

[18]         Mei-Hua Ye, Da-Wei Li, Qiu-Die Cai, Yu-Hu Jiao, Yang Liu, Hong-Ye Li, Wei-Dong Yang*, 2022. Toxic responses of different shellfish species after exposure to Prorocentrum lima, a DSP toxins producing dinoflagellate. Toxins14, 461.https://doi.org/10.3390 /toxins14070461

[19]         Yang Liu, Yang Lu, Yu-Hu Jiao, Da-Wei Li, Hong-Ye Li, Wei-Dong Yang*, 2022. Multi-omics analysis reveals metabolism of okadaic acid in gut lumen of rat. Arch. Toxicol. 2022， 96, 831–843. https://doi.org/10.1007/s00204-021-03219-5

[20]         Jin-jin Lv, Kuan-kuan Yuan, Mi-yu Lu, Zheng-bing He, Hong-ye Li, Wei-dong Yang*, 2021. Responses of JNK signaling pathway to the toxic dinoflagellate Prorocentrum limain the mussel Perna viridis. Ecotoxicol. Environ. Saf. 227, 112905.https://doi.org/10.1016/j.ecoenv.2021.112905

[21]         Jia-hui Huang, Yu-hu Jiao, Li Li, Da-wei Li, Hong-ye Li, Wei-dong Yang*, 2021. Small RNA analysis of Perna viridis after exposure to Prorocentrum lima, a DSP toxins-producing dinoflagellate. Aquat. Toxicol. 239, 105950. https://doi.org/10.1016/j.aquatox.2021.105950

[22]         Kuan-Kuan Yuan, Guo-Fang Duan, Qing-Yuan Liu, Hong-Ye Li, Wei-Dong Yang*, 2021. Inhibition of diarrheal shellfish toxins accumulation in the mussel Perna viridis by curcumin and underlying mechanisms. Toxins 13(8), 578. https://doi.org/10.3390/toxins13080578.

[23]         Yu-hu Jiao, Guang Wang, Da-wei Li, Hong-ye Li, Jie-sheng Liu, Xue-song Yang*, Wei-dong Yang*, 2021. Okadaic acid exposure induced neural tube defects in chicken (Gallus gallus) embryos. Mar. Drugs 19, 322. https://doi.org/10.3390/md19060322

[24]         Hong-Jia Huang, Chu-Qiao Gan, Jia-Hui Huang, Chen Zou, Hong-Ye Li, Jie-Sheng Liu, Wei-Dong Yang*, 2021. Variability of Prorocentrum donghaiense response to allelopathic action from Alexandrium pacificum in laboratory culture. J. Oceanol. Limnol. 39(4), 1305-1315.https://doi.org/10.1007/s00343-020-0226-z

[25]         Xiao-Tong Mao, Rui-Xia Xu, Yu Gao, Hong-Ye Li, Jie-Sheng Liu, Wei-Dong Yang*, 2021. Allelopathy of Alexandrium pacificum on Thalassiosira pseudonana in laboratory cultures. Ecotoxicol. Environ. Saf. 215(1), 112123. https://doi.org/10.1016/j.ecoenv.2021.112123

[26]         Jian-Wei Zheng, Xiao-Tong Mao, Mei-Hua Ye, Hong-Ye Li, Jie-Sheng Liu, Wei-Dong Yang*, 2021. Allelopathy and underlying mechanism of Karenia mikimotoi on the diatom Thalassiosira pseudonanaunder laboratory condition. Algal Res. 54, 102229. https://doi.org/10.1016/j.algal.2021.102229

[27]         Guo-Fang Duan, Yang Liu, Li-Na Zhang, Hong-Ye Li, Jie-Sheng Liu, Wei-Dong Yang*, 2021. Cinnamaldehyde could reduce the accumulation of diarrhetic shellfish toxins in the digestive gland of the mussel Perna viridis under laboratory conditions. Mar. Drugs 19(2), 63. https://doi.org/10.3390/md19020063

[28]         Qian Ye, Jia-hui Huang, Meng Li, Hong-Ye Li, Jie-Sheng Liu, Song-hui Lv*, Wei-dong Yang*, 2020. Responses of cytochrome P450, GST and MXR in the mussel Perna viridis to the exposure of Aureococcus anophagefferens. Mar. Pollut. Bull. 161, 111806. https://doi.org/10.1016/j.marpolbul.2020.111806

[29]         Yang Liu, Jian-Wei Zheng, Xi-Chun Peng*, Hong-Ye Li, Lu Huang, Da-Wei Li, Jie-Sheng Liu, Wei-Dong Yang*, 2020. Changes in colonic microbiotas in rat after long-term exposure to low dose of okadaic acid. Chemosphere 254, 126874. https://doi.org/10.1016/j.chemosphere.2020.126874

[30]         Hong-jia Huang, Chu-qiao Gan, Shao-wen Xiao, Cheng Zou, Srinivasan Balamurugan, Hong-ye Li, Jie-sheng Liu, Wei-dong Yang*, 2020. Genetic diversity of Prorocentrum donghaiense population during bloom in the East China Sea revealed by microsatellite. J. Appl. Phycol. 32(3), 1851-1862 https://doi.org/10.1007/s10811-020-02113-4

[31]         Min Dou, Yu-hu Jiao, Jian-Wei Zheng, Gong Zhang*, Hong-Ye Li, Jie-Sheng Liu, Wei-Dong Yang*, 2020. De novo transcriptome analysis of the mussel Perna viridis after exposure to the toxic dinoflagellate Prorocentrum lima. Ecotoxicol. Environ. Saf. 192, 110265. https://doi.org/10.1016/j.ecoenv.2020.110265

1、杨维东，刘洁生，彭喜春. 微量元素与健康, 武汉: 华中科技大学出版社，2007

2、齐雨藻等著. 中国南海赤潮研究. 广州: 广东经济出版社, 2008 (撰写：赤潮毒素及其毒理学)

3、刘洁生, 朱伟杰, 王子栋. 环境生理学. 北京: 科学出版社, 2011. (参编)

1.  国家重点研发计划项目：秦皇岛海域生态灾害多发原因及监测预警系统研究（2019YFC1407900），2019.12-2021.12，1649.00万，主持

2.  国家自然科学基金面上项目：贝类p38 MAPK通过Nrf2信号通路和ABC转运蛋白对DSP毒素毒性响应的调控及其机制（42476125），2025.1-2028.12, 48万（直接经费），主持

3. 国家自然科学基金面上项目：贝类异源物核受体介导贝体中腹泻性贝毒代谢解毒的机制研究（42076143），2021.1-2024.12, 58万（直接经费），主持

4. 国家自然科学基金面上项目：贝类Nrf2/ARE信号通路参与腹泻性贝毒代谢解毒的分子机制（41776120），2018.1-2021.12, 69万（直接经费），主持

5. 国家自然科学基金面上项目：双壳贝类细胞色素P450及其在腹泻性贝毒代谢解毒机制中的作用研究（41576116），2016.1-2019.12, 69万（直接经费），主持

6.  国家自然科学基金面上项目：中国沿海典型产毒甲藻塔玛亚历山大藻的遗传多样性与种源分析（41176088），2012.1-2015.12，69万，主持

7.  国家自然科学基金面上项目：p-糖蛋白在双壳贝类抗腹泻性贝毒中的作用机制研究（40976065），2010.1-2012.12，44万，主持

[1]    李宏业, 李达伟, 黄小龙, 黄丹, 杨维东. 一种物种基因组的启动子查询方法、系统及设备. 2021-10-15, 中国, ZL202110822106.X

[2]    叶林顺, 刘洁生, 杨维东, 欧浩楠, 黄隽萍, 梁泽雄, 王雅妮. 一种制备高胺基含量的改性海绵的方法和装置及除藻应用. 2021-5-20, CN202110550297.9

[3]    李宏业, 李达伟, 杨维东, 刘洁生. 一种DNA序列及其应用. 2017-2-21, 中国, ZL201710092923.8

[4]  李宏业, 李达伟, 杨维东, 刘洁生. 一种干扰基因及其应用. 2017-2-21, 中国, ZL201710093488.

现兼任广东省高等学校生物类教学指导委员会副主任委员，广东省生理学会副理事长。曾担任《生态毒理学报》编委。