暨南大学教授，博士生导师，《生态毒理学报》编委，广东省生理学会副理事长，广东省高等学校生物类教学指导委员会副主任委员。主要从事赤潮毒素对人类健康的危害、环境生物对赤潮毒素的响应与解毒机制、赤潮毒素的生态学意义与生物合成机制等的研究。近年来主持国家重点研发项目（2019YFC1407900）、国家自然科学基金（42076143，41776120，41576116，41176088，40976065）等项目多项，在Chemosphere、Aquat Toxicol、Environ Pollut、Algal Res等期刊发表SCI论文30余篇，获教育部高等学校科学研究优秀成果奖（科学技术）二等奖1项，授权专利6项，广东省教育教学成果一等奖2项、二等奖1项。

1989年 本科毕业于西北师范大学化学系

1992年 在西北师范大学化学系获得理学硕士学位

1999年 在中山大学化学化工学院获得理学博士学位

1992-1996 在兰州大学药学院（原兰州医学院药学系）任教

1999年 入职暨南大学生命科学技术学院，先后任讲师、副教授（2000）、教授（2006）。

1、赤潮毒素与人类健康

2、赤潮毒素与水产品安全；

3、水生态毒理学

[1]             Qin-yuan Liu, Zi-min Chen, Da-wei Li, Ai-feng Li, Ying Ji, Hong-ye Li, Wei-dong Yang*, 2023. Toxicity and potential underlying mechanism of Karenia selliformis to the fish Oryzias melastigma. Aquat. Toxicol. 262, 106643

[2]             Yang Liu, Tian-Qing Yuan, Jian-Wei Zheng, Yu-Hu Jiao, Da-Wei Li, Hong-Ye Li, Rui-Man Li*, Wei-Dong Yang*, 2023. Exposure to okadaic acid could disrupt the colonic microenvironment in rats. Ecotoxicol. Environ. Saf. 263, 115376

[3]             Jian-Wei Zheng, Guo-Hui He, Rui-Xia Xu, Xiang Wang, Hong-Ye Li, Wei-Dong Yang, 2023. Systematic exploration of transcriptional responses of interspecies interaction between Karenia mikimotoi and Prorocentrum shikokuense. Harmful Algae 126, 102441. https://doi.org/10.1016/j.hal.2023.102441

[4]             Yang Liu, Chun-Li Qi, Da-Wei Li, Hong-Ye Li, Rui-Man Li*, Wei-Dong Yang*, 2023. Microcystin-LR exposure interfered maintenance of colonic microenvironmental homeostasis in rat. Food Chem. Toxicol. 173, 113611https://doi.org/10.1016/j.fct.2023.113611

[5]             Kuan-Kuan Yuan, Zi-Min Chen, Ya-Xin Liu, Hong-Ye Li, Wei-Dong Yang*, 2023. Possible role of docosahexaenoic acid in response to diarrhetic shellfish toxins in the mussel Perna viridis. Mar. Drugs 21, 155.

[6]             Jin-Jin Lv, Kuan-Kuan Yuan, Guan-Xiu Lu, Hong-Ye Li,Hang Fai Kwok, Wei-dong Yang*, 2023. Responses of ABCB and ABCC transporters to the toxic dinoflagellate Prorocentrum lima in the mussel Perna viridis.Aquat. Toxicol. 254, 106368.doi:10.1016/j.aquatox.2022.106368

[7]             Zhihui Cai, Yutian Zhang, Zhang Weijie Zhang, Jinmin Ye, Qinjie Ling, Zhi Xing, Sichun Zhang, Peter R. Hoffmann, Youbin Liu*, Weidong Yang*, Zhi Huang*, 2022. Arsenic retention in erythrocytes and excessive erythrophagocytosis is related to low selenium status by impaired redox homeostasis. Redox Biology 52, 102321 DOI: 10.1016/j.redox.2022.102321

[8]             Li Li, Shuang Chen, Si-yuan Xu, Da-wei Li*, Hong-ye Li, Wei-dong Yang*, 2022.Toxicity and underlying mechanism of the toxic dinoflagellate Gambierdiscuscaribaeus tothe fish Oryzias melastigma. Ecotoxicol. Environ. Saf. 247, 114223

[9]             Yang Liu, Si-Yuan Xu, Qiu-Die Cai, Da-Wei Li, Hong-Ye Li, Wei-Dong Yang*, 2022. In vitro interactions between okadaic acid and rat gut microbiome. Mar. Drugs 20, 556. https://doi.org/10.3390/md20090556

[10]         Mei-Hua Ye, Da-Wei Li, Qiu-Die Cai, Yu-Hu Jiao, Yang Liu, Hong-Ye Li, Wei-Dong Yang*, 2022. Toxic responses of different shellfish species after exposure to Prorocentrum lima, a DSP toxins producing dinoflagellate. Toxins14, 461. https://doi.org/10.3390 /toxins14070461

[11]         Yang Liu, Yang Lu, Yu-Hu Jiao, Da-Wei Li, Hong-Ye Li, Wei-Dong Yang*, 2022. Multi-omics analysis reveals metabolism of okadaic acid in gut lumen of rat. Arch. Toxicol. 2022， 96, 831–843. https://doi.org/10.1007/s00204-021-03219-5

[12]         Jin-jin Lv, Kuan-kuan Yuan, Mi-yu Lu, Zheng-bing He, Hong-ye Li, Wei-dong Yang*, 2021. Responses of JNK signaling pathway to the toxic dinoflagellate Prorocentrum lima in the mussel Perna viridis. Ecotoxicol. Environ. Saf. 227, 112905. https://doi.org/10.1016/j.ecoenv.2021.112905

[13]         Jia-hui Huang, Yu-hu Jiao, Li Li, Da-wei Li, Hong-ye Li, Wei-dong Yang*, 2021. Small RNA analysis of Perna viridis after exposure to Prorocentrum lima, a DSP toxins-producing dinoflagellate. Aquat. Toxicol. 239, 105950. https://doi.org/10.1016/j.aquatox.2021.105950

[14]         Kuan-Kuan Yuan, Guo-Fang Duan, Qing-Yuan Liu, Hong-Ye Li, Wei-Dong Yang*, 2021. Inhibition of diarrheal shellfish toxins accumulation in the mussel Perna viridis by curcumin and underlying mechanisms. Toxins 13(8), 578. https://doi.org/10.3390/toxins13080578.

[15]         Yu-hu Jiao, Guang Wang, Da-wei Li, Hong-ye Li, Jie-sheng Liu, Xue-song Yang*, Wei-dong Yang*, 2021. Okadaic acid exposure induced neural tube defects in chicken (Gallus gallus) embryos. Mar. Drugs 19, 322. https://doi.org/10.3390/md19060322

[16]         Hong-Jia Huang, Chu-Qiao Gan, Jia-Hui Huang, Chen Zou, Hong-Ye Li, Jie-Sheng Liu, Wei-Dong Yang*, 2021. Variability of Prorocentrum donghaiense response to allelopathic action from Alexandrium pacificum in laboratory culture. J. Oceanol. Limnol. 39(4), 1305-1315.https://doi.org/10.1007/s00343-020-0226-z

[17]         Xiao-Tong Mao, Rui-Xia Xu, Yu Gao, Hong-Ye Li, Jie-Sheng Liu, Wei-Dong Yang*, 2021. Allelopathy of Alexandrium pacificum on Thalassiosira pseudonana in laboratory cultures. Ecotoxicol. Environ. Saf. 215(1), 112123. https://doi.org/10.1016/j.ecoenv.2021.112123

[18]         Jian-Wei Zheng, Xiao-Tong Mao, Mei-Hua Ye, Hong-Ye Li, Jie-Sheng Liu, Wei-Dong Yang*, 2021. Allelopathy and underlying mechanism of Karenia mikimotoi on the diatom Thalassiosira pseudonana under laboratory condition. Algal Res. 54, 102229. https://doi.org/10.1016/j.algal.2021.102229

[19]         Guo-Fang Duan, Yang Liu, Li-Na Zhang, Hong-Ye Li, Jie-Sheng Liu, Wei-Dong Yang*, 2021. Cinnamaldehyde could reduce the accumulation of diarrhetic shellfish toxins in the digestive gland of the mussel Perna viridis under laboratory conditions. Mar. Drugs 19(2), 63. https://doi.org/10.3390/md19020063

[20]         Qian Ye, Jia-hui Huang, Meng Li, Hong-Ye Li, Jie-Sheng Liu, Song-hui Lv*, Wei-dong Yang*, 2020. Responses of cytochrome P450, GST and MXR in the mussel Perna viridis to the exposure of Aureococcus anophagefferens. Mar. Pollut. Bull. 161, 111806. https://doi.org/10.1016/j.marpolbul.2020.111806

[21]         Yang Liu, Jian-Wei Zheng, Xi-Chun Peng*, Hong-Ye Li, Lu Huang, Da-Wei Li, Jie-Sheng Liu, Wei-Dong Yang*, 2020. Changes in colonic microbiotas in rat after long-term exposure to low dose of okadaic acid. Chemosphere 254, 126874. https://doi.org/10.1016/j.chemosphere.2020.126874

[22]         Min Dou, Yu-hu Jiao, Jian-Wei Zheng, Gong Zhang*, Hong-Ye Li, Jie-Sheng Liu, Wei-Dong Yang*, 2020. De novo transcriptome analysis of the mussel Perna viridis after exposure to the toxic dinoflagellate Prorocentrum lima. Ecotoxicol. Environ. Saf. 192, 110265. https://doi.org/10.1016/j.ecoenv.2020.110265

[23]         Yu-hu Jiao, Meng Liu, Guang Wang, Hong-ye Li, Jie-sheng Liu, Xuesong Yang*, Wei-dong Yang*, 2019. EMT is the major target for okadaic acid-suppressed the development of neural crest cells in chick embryo. Ecotoxicol. Environ. Saf. 180, 192–201. https://doi.org/10.1016/j.ecoenv.2019.05.015

[24]         Zheng-bingHe, Guo-fangDuan, Cai-yingLiang, Hong-yeLi, Jie-shengLiu, Wei-dongYang∗, 2019. Up-regulation of Nrf2-dependent antioxidant defenses inPerna viridisafter exposed toProrocentrum lima. Fish Shellfish Immunol. 90, 173–179. https://doi.org/10.1016/j.fsi.2019.05.003

[25]         Xiao-Meng Wei, Mi-Yu Lu, Guo-Fang Duan, Hong-Ye Li, Jie-Sheng Liu, Wei-Dong Yang*, 2019. Responses of CYP450 in the mussel Perna viridis after short-term exposure to the DSP toxins-producing dinoflagellate Prorocentrum lima. Ecotoxicol. Environ. Saf. 176, 178–185. https://doi.org/10.1016/j.ecoenv.2019.03.073

[26]         Song Gu, Shao-Wen Xiao, Jian-Wei Zheng, Hong-Ye Li, Jie-Sheng Liu and Wei-Dong Yang*, 2019. ABC transporters in Prorocentrum lima and their expression under different environmental conditions including okadaic acid production. Mar. Drugs 17, 259. https://doi.org/10.3390/md17050259

[27]         Jian-wei Zheng, Su-li Liu, Song-Hui Lu*, Hong-ye Li, Jie-sheng Liu, Wei-dong Yang*, 2018. Proteomic profile in the mussel Perna viridis after short-term exposure to the brown tide alga Aureococcus anophagefferens. Ecotoxicol. Environ. Saf. 162, 365–375. https://doi.org/10.1016/j.ecoenv.2018.07.012

[28]         Dao-yi Hou, Xiao-tong Mao, Song Gu, Hong-ye Li, Jie-sheng Liu, Wei-dong Yang*, 2018, Systems-level analysis of metabolic mechanism following nitrogen limitation in benthic dinoflagellate Prorocentrum lima. Algal Res. 33, 389–398. https://doi.org/10.1016/j.algal.2018.06.004

[29]         Yue Li, Hong-jia Huang, Hongye Li, Jiesheng Liu, Weidong Yang*, 2016. Genetic diversity of Ulva prolifera population in Qingdao coastal water during the green algal blooms revealed by microsatellite. Mar. Pollut. Bull. 111, 237-246.

[30]         Lu Huang, Su-Li Liu, Jian-Wei Zheng, Hong-Ye Li, Jie-Sheng Liu, Wei-Dong Yang*, 2015.P-glycoprotein and its inducible expression in three bivalve species after exposure to Prorocentrum lima. Aquat. Toxicol. 169, 123-132.

[31]         Jian Chen, Qian Ye, Hai-Feng Gu, Hong-Ye Li, Song-Hui Lv, Jie-Sheng Liu*, Wei-Dong Yang*, 2015. Variability in the allelopathic action of the Alexandrium tamarense species complex along the coast of China. Harmful Algae 47, 17–26.

[32]         Lu Huang, Ying Zou, Hui-wen Weng, Hong-Ye Li, Jie-Sheng Liu*, Wei-Dong Yang*, 2015. Proteomic profile in Perna viridis after exposed to Prorocentrum lima, a dinoflagellate producing DSP toxins. Environ. Pollut. 196, 350-357.

[33]         Lu Huang,Jie Wang,Wen-Chang Chen,Hong-Ye Li,Jie-Sheng Liu*, TaoJiang,Wei-Dong Yang*, 2014. P-glycoprotein expression inPerna viridisafter exposure to Prorocentrum lima, a dinoflagellate producing DSP toxins. Fish Shellfish Immunol. 39(2), 254–262.

[34]         Cheng Zou,Rui-Min Ye,Jian-Wei Zheng,Zhao-He Luo,Hai-Feng Gu,Wei-Dong Yang*,Hong-Ye Li,Jie-Sheng Liu*,2014.Molecular phylogeny and PSP toxin profile of the Alexandrium tamarense species complex along the coast of China.Mar. Pollut. Bull. 89, 209–219.

[35]         Nai-sheng Zhang, Hong-Ye Li, Jie-Sheng Liu,Wei-Dong Yang*, 2014. Gene expression profiles in zebrafish (Danio rerio) liver after acute exposure to okadaic acid. Environ. Toxicol. Pharmacol. 37(2), 791–802.

[36]         Yan-yan Xu, Jin-Jin Liang, Wei-Dong Yang*, Jie Wang, Hong-Ye Li, Jie-Sheng Liu*, 2014.Cloning and expression analysis of P-glycoprotein gene in Crassostrea ariakensis. Aquaculture 418–419, 39–47.

1、杨维东，刘洁生，彭喜春. 微量元素与健康, 武汉: 华中科技大学出版社，2007

2、齐雨藻等著. 中国南海赤潮研究. 广州: 广东经济出版社, 2008 (撰写：赤潮毒素及其毒理学)

3、刘洁生, 朱伟杰, 王子栋. 环境生理学. 北京: 科学出版社, 2011. (参编)

1、国家重点研发计划项目：秦皇岛海域生态灾害多发原因及监测预警系统研究（2019YFC1407900），2019.12-2021.12，1649.00万，主持

2、国家自然科学基金面上项目：贝类异源物核受体介导贝体中腹泻性贝毒代谢解毒的机制研究（42076143），2021.1-2024.12, 58万（直接经费），主持

3、国家自然科学基金面上项目：贝类Nrf2/ARE信号通路参与腹泻性贝毒代谢解毒的分子机制（41776120），2018.1-2021.12, 69万（直接经费），主持

4、国家自然科学基金面上项目：双壳贝类细胞色素P450及其在腹泻性贝毒代谢解毒机制中的作用研究（41576116），2016.1-2019.12, 69万（直接经费），主持

5、国家自然科学基金面上项目：中国沿海典型产毒甲藻塔玛亚历山大藻的遗传多样性与种源分析（41176088），2012.1-2015.12，69万，主持

6、国家自然科学基金面上项目：p-糖蛋白在双壳贝类抗腹泻性贝毒中的作用机制研究（40976065），2010.1-2012.12，44万，主持

[1]       李宏业, 李达伟, 黄小龙, 黄丹, 杨维东. 一种物种基因组的启动子查询方法、系统及设备. 2021-10-15, 中国, ZL202110822106.X

[2]       叶林顺, 刘洁生, 杨维东, 欧浩楠, 黄隽萍, 梁泽雄, 王雅妮. 一种制备高胺基含量的改性海绵的方法和装置及除藻应用. 2021-5-20, CN202110550297.9

[3]       李宏业, 李达伟, 杨维东, 刘洁生. 一种DNA序列及其应用. 2017-2-21, 中国, ZL201710092923.8

[4]  李宏业, 李达伟, 杨维东, 刘洁生. 一种干扰基因及其应用. 2017-2-21, 中国, ZL201710093488.

现兼任广东省高等学校生物类教学指导委员会副主任委员，广东省生理学会副理事长。曾担任《生态毒理学报》编委。