暨南大学教授，博士生导师，《生态毒理学报》编委，广东省生理学会副理事长，广东省高等学校生物类教学指导委员会副主任委员。主要从事赤潮毒素对人类健康的危害、环境生物对赤潮毒素的响应与解毒机制、赤潮毒素的生态学意义与生物合成机制等的研究。近年来主持国家重点研发项目（2019YFC1407900）、国家自然科学基金（42076143，41776120，41576116，41176088，40976065）等项目多项，在Chemosphere、Aquat Toxicol、Environ Pollut、Algal Res等期刊发表SCI论文30余篇，获教育部高等学校科学研究优秀成果奖（科学技术）二等奖1项，授权专利6项，广东省教育教学成果一等奖2项、二等奖1项。

1989年 本科毕业于西北师范大学化学系

1992年 在西北师范大学化学系获得理学硕士学位

1999年 在中山大学化学化工学院获得理学博士学位

1992-1996 在兰州大学药学院（原兰州医学院药学系）任教

1999年 入职暨南大学生命科学技术学院，先后任讲师、副教授（2000）、教授（2006）。

1、赤潮毒素与人类健康

2、赤潮毒素与水产品安全；

3、水生态毒理学

[1]Jia-hui Huang, Yu-hu Jiao, Li Li, Da-wei Li, Hong-ye Li, Wei-dong Yang*, 2021. Small RNA analysis of Perna viridis after exposure to Prorocentrum lima, a DSP toxins-producing dinoflagellate. Aquat. Toxicol. 239, 105950. https://doi.org/10.1016/j.aquatox.2021.105950

[2]Kuan-Kuan Yuan, Guo-Fang Duan, Qing-Yuan Liu, Hong-Ye Li, Wei-Dong Yang*, 2021. Inhibition of diarrheal shellfish toxins accumulation in the mussel Perna viridis by curcumin and underlying mechanisms. Toxins 13(8), 578. https://doi.org/10.3390/toxins13080578.

[3]Yu-hu Jiao, Guang Wang, Da-wei Li, Hong-ye Li, Jie-sheng Liu, Xue-song Yang*, Wei-dong Yang*, 2021. Okadaic acid exposure induced neural tube defects in chicken (Gallus gallus) embryos. Mar. Drugs 19, 322. https://doi.org/10.3390/md19060322

[4]Hong-Jia Huang, Chu-Qiao Gan, Jia-Hui Huang, Chen Zou, Hong-Ye Li, Jie-Sheng Liu, Wei-Dong Yang*, 2021. Variability of Prorocentrum donghaiense response to allelopathic action from Alexandrium pacificum in laboratory culture. J. Oceanol. Limnol. 39(4), 1305-1315.https://doi.org/10.1007/s00343-020-0226-z

[5]Xiao-Tong Mao, Rui-Xia Xu, Yu Gao, Hong-Ye Li, Jie-Sheng Liu, Wei-Dong Yang*, 2021. Allelopathy of Alexandrium pacificum on Thalassiosira pseudonana in laboratory cultures. Ecotoxicol. Environ. Saf. 215(1), 112123

[6]Jian-Wei Zheng, Xiao-Tong Mao, Mei-Hua Ye, Hong-Ye Li, Jie-Sheng Liu, Wei-Dong Yang*, 2021. Allelopathy and underlying mechanism of Karenia mikimotoi on the diatom Thalassiosira pseudonanaunder laboratory condition. Algal Res. 54, 102229

[7]Guo-Fang Duan, Yang Liu, Li-Na Zhang, Hong-Ye Li, Jie-Sheng Liu, Wei-Dong Yang*, 2021. Cinnamaldehyde could reduce the accumulation of diarrhetic shellfish toxins in the digestive gland of the mussel Perna viridis under laboratory conditions. Mar. Drugs 19(2), 63.

[8]Qian Ye, Jia-hui Huang, Meng Li, Hong-Ye Li, Jie-Sheng Liu, Song-hui Lv*, Wei-dong Yang*, 2020. Responses of cytochrome P450, GST and MXR in the mussel Perna viridis to the exposure of Aureococcus anophagefferens. Mar. Pollut. Bull. 161, 111806

[9]Yang Liu, Jian-Wei Zheng, Xi-Chun Peng*, Hong-Ye Li, Lu Huang, Da-Wei Li, Jie-Sheng Liu, Wei-Dong Yang*, 2020. Changes in colonic microbiotas in rat after long-term exposure to low dose of okadaic acid. Chemosphere 254, 126874. https://doi.org/10.1016/j.chemosphere.2020.126874

[10]Hong-jia Huang, Chu-qiao Gan, Shao-wen Xiao, Cheng Zou, Srinivasan Balamurugan, Hong-ye Li, Jie-sheng Liu, Wei-dong Yang*, 2020. Genetic diversity of Prorocentrum donghaiense population during bloom in the East China Sea revealed by microsatellite. J. Appl. Phycol. 32(3), 1851-1862 https://doi.org/10.1007/s10811-020-02113-4

[11]Min Dou, Yu-hu Jiao, Jian-Wei Zheng, Gong Zhang*, Hong-Ye Li, Jie-Sheng Liu, Wei-Dong Yang*, 2020. De novo transcriptome analysis of the mussel Perna viridis after exposure to the toxic dinoflagellate Prorocentrum lima. Ecotoxicol. Environ. Saf. 192, 110265

[12]Yu-hu Jiao, Meng Liu, Guang Wang, Hong-ye Li, Jie-sheng Liu, Xuesong Yang*, Wei-dong Yang*, 2019. EMT is the major target for okadaic acid-suppressed the development of neural crest cells in chick embryo. Ecotoxicol. Environ. Saf. 180, 192–201.

[13]Zheng-bingHe, Guo-fangDuan, Cai-yingLiang, Hong-yeLi, Jie-shengLiu, Wei-dongYang∗, 2019. Up-regulation of Nrf2-dependent antioxidant defenses inPerna viridisafter exposed toProrocentrum lima. Fish Shellfish Immunol. 90, 173–179. 3.298

[14]Xiao-Meng Wei, Mi-Yu Lu, Guo-Fang Duan, Hong-Ye Li, Jie-Sheng Liu, Wei-Dong Yang*, 2019. Responses of CYP450 in the mussel Perna viridis after short-term exposure to the DSP toxins-producing dinoflagellate Prorocentrum lima. Ecotoxicol. Environ. Saf. 176, 178–185.

[15]Song Gu, Shao-Wen Xiao, Jian-Wei Zheng, Hong-Ye Li, Jie-Sheng Liu and Wei-Dong Yang*, 2019. ABC transporters in Prorocentrum lima and their expression under different environmental conditions including okadaic acid production. Mar. Drugs 17, 259.

[16]Jian-wei Zheng, Su-li Liu, Song-Hui Lu*, Hong-ye Li, Jie-sheng Liu, Wei-dong Yang*, 2018. Proteomic profile in the mussel Perna viridis after short-term exposure to the brown tide alga Aureococcus anophagefferens. Ecotoxicol. Environ. Saf. 162, 365–375

[17]Dao-yi Hou, Xiao-tong Mao, Song Gu, Hong-ye Li, Jie-sheng Liu, Wei-dong Yang*, 2018, Systems-level analysis of metabolic mechanism following nitrogen limitation in benthic dinoflagellate Prorocentrum lima. Algal Res. 33, 389–398.

[18]Yu-hu Jiao, Min Dou, Guang Wang, Hong-ye Li, Jie-sheng Liu, Xuesong Yang*, Wei-dong Yang*, 2017. Exposure of okadaic acid alters the angiogenesis in developing chick embryos. Toxicon 133, 74-81.

[19]Dao-yi Hou, Jin-jin Liang, Cheng Zou, Hong-ye Li, Jie-sheng Liu*, Wei-dong Yang*, 2016. MRP functional activity and character in the dinoflagellate Prorocentrum lima. J. Appl. Phycol.28(3), 1667–1676.

[20]Fei Liu, Zheng-Bing He, Hong-Ye Li, Jie-Sheng Liu*, Wei-Dong Yang*, 2016. Inhibition of five natural products from Chinese herbs on the growth of Chattonella marina. Environ. Sci. Pollut. Res. 23(17), 17793-17800.

[21]Yue Li, Hong-jia Huang, Hongye Li, Jiesheng Liu, Weidong Yang*, 2016. Genetic diversity of Ulva prolifera population in Qingdao coastal water during the green algal blooms revealed by microsatellite. Mar. Pollut. Bull. 111, 237-246.

[22]Lu Huang, Su-Li Liu, Jian-Wei Zheng, Hong-Ye Li, Jie-Sheng Liu, Wei-Dong Yang*, 2015.P-glycoprotein and its inducible expression in three bivalve species after exposure to Prorocentrum lima. Aquat. Toxicol. 169, 123-132.

[23]Jin-Jin Liang, Yun-Hui Li, Fei Liu, Hong-Ye Li, Jie-Sheng Liu*, Wei-Dong Yang*, 2015. Experimental removal of Alexandrium tamarense cells using sulfobetaines and their modified clays. J. Appl. Phycol. 27(6), 2313-2319.

[24]Jian Chen, Qian Ye, Hai-Feng Gu, Hong-Ye Li, Song-Hui Lv, Jie-Sheng Liu*, Wei-Dong Yang*, 2015. Variability in the allelopathic action of the Alexandrium tamarense species complex along the coast of China. Harmful Algae 47, 17–26.

[25]Lin-Xi Dang, Yue Li, Fei Liu, Yong Zhang, Wei-Dong Yang*, Hong-Ye Li,Jie-Sheng Liu, 2015.Chemical response of the toxic dinoflagellate Karenia mikimotoiagainst grazing by three species of zooplankton. J. Eukaryot. Microbiol. 62, 470–480.

[26]Lu Huang, Ying Zou, Hui-wen Weng, Hong-Ye Li, Jie-Sheng Liu*, Wei-Dong Yang*, 2015. Proteomic profile in Perna viridis after exposed to Prorocentrum lima, a dinoflagellate producing DSP toxins. Environ. Pollut. 196, 350-357.

[27]Ying Zou, Xiao-Meng Wei, Hui-Wen Weng, Hong-Ye Li, Jie-Sheng Liu, Wei-Dong Yang*, 2015. Expression profile of eight glutathione S-transferase genes in Crassostrea ariakensis after exposure to DSP toxins producing dinoflagellate Prorocentrum lima. Toxicon 105, 45–55.

[28]Lu Huang,Jie Wang,Wen-Chang Chen,Hong-Ye Li,Jie-Sheng Liu*, TaoJiang,Wei-Dong Yang*, 2014. P-glycoprotein expression inPerna viridisafter exposure to Prorocentrum lima, a dinoflagellate producing DSP toxins. Fish Shellfish Immunol. 39(2), 254–262.

[29]Cheng Zou,Rui-Min Ye,Jian-Wei Zheng,Zhao-He Luo,Hai-Feng Gu,Wei-Dong Yang*,Hong-Ye Li,Jie-Sheng Liu*,2014.Molecular phylogeny and PSP toxin profile of the Alexandrium tamarense species complex along the coast of China.Mar. Pollut. Bull. 89, 209–219.

[30]Yan-yan Xu, Jin-Jin Liang, Wei-Dong Yang*, Jie Wang, Hong-Ye Li, Jie-Sheng Liu*, 2014.Cloning and expression analysis of P-glycoprotein gene in Crassostrea ariakensis. Aquaculture 418–419, 39–47.

1、杨维东，刘洁生，彭喜春. 微量元素与健康, 武汉: 华中科技大学出版社，2007

2、齐雨藻等著. 中国南海赤潮研究. 广州: 广东经济出版社, 2008 (撰写：赤潮毒素及其毒理学)

3、刘洁生, 朱伟杰, 王子栋. 环境生理学. 北京: 科学出版社, 2011. (参编)

1、国家重点研发计划项目：秦皇岛海域生态灾害多发原因及监测预警系统研究（2019YFC1407900），2019.12-2021.12，1649.00万，主持

2、国家自然科学基金面上项目：贝类异源物核受体介导贝体中腹泻性贝毒代谢解毒的机制研究（42076143），2021.1-2024.12, 58万（直接经费），主持

3、国家自然科学基金面上项目：贝类Nrf2/ARE信号通路参与腹泻性贝毒代谢解毒的分子机制（41776120），2018.1-2021.12, 69万（直接经费），主持

4、国家自然科学基金面上项目：双壳贝类细胞色素P450及其在腹泻性贝毒代谢解毒机制中的作用研究（41576116），2016.1-2019.12, 69万（直接经费），主持

5、国家自然科学基金面上项目：中国沿海典型产毒甲藻塔玛亚历山大藻的遗传多样性与种源分析（41176088），2012.1-2015.12，69万，主持

6、国家自然科学基金面上项目：p-糖蛋白在双壳贝类抗腹泻性贝毒中的作用机制研究（40976065），2010.1-2012.12，44万，主持

[1]杨维东，李赟辉，李宏业，刘洁生. 一种甜菜碱衍生物改性粘土及其制备方法和应用. 专利号：201310087281.4；申请日：2015.2.18；授权公告日：2013.7.24；授权公告号：CN103214076A

[2]李宏业，刘婉君，陈嘉雯，杨维东，刘洁生. 一种微藻组成型表达启动子及其应用. 专利号：ZL201610269811.0；申请日：2016.4.26；授权公告日：2018.6.15；授权公告号：CN105838715B

[3]李宏业，谢伟红，朱聪聪，杨维东，刘洁生. 一种高效克隆及表达的微藻叶绿体载体及其应用. 专利号：ZL201310263325.4；授权公告日：2015.2.18；公开（公告）号: CN103352048B

[4]李宏业，朱聪聪，杨维东，刘洁生. 一种海洋微藻叶绿体转化载体及其应用. 专利号：ZL201010285197.X；授权公告日：2012.07.18；公开（公告）号：CN101948871B

《生态毒理学报》编委，广东省高等学校生物类教学指导委员会副主任委员，广东省生理学会副理事长。