个人信息

头像

姓名: 赵海明

部门: 生命科学技术学院

性别:

职务: 硕士生导师

职称: 副研究员

学位: 博士

毕业院校: 暨南大学

联系电话: 15013153430

电子邮箱: zhaohm99@jnu.edu.cn

办公地址: 校本部第二理工楼418室

通讯地址: 广州市天河区石牌暨南大学生命科学技术学院

邮编: 510632

传真:

荣誉奖励:

联系方式

个人简介

赵海明,男,2016年于暨南大学获理学博士学位,之后分别于暨南大学和美国佛罗里达大学从事博士后研究,现任暨南大学生科院副研究员、硕士生导师。长期从事土壤有机污染物修复与农产品安全领域研究工作。针对我国土壤遭受有机污染的严峻形势,系统研究了土壤-作物系统中有机污染物 (如邻苯二甲酸酯/PAEs、抗生素、全氟化合物、微囊藻毒素等) 的污染特征、环境行为、生物富集、健康风险、生物修复等,主要研究成果包括:

1)筛选获得多个典型有机污染物(PAEs、抗生素、全氟化合物等)低累积作物品种,并从植物生理生化和分子生物学等方面阐明了作物低吸收累积有机污染物的形成机制;

2)分离获得多个典型有机污染物高效降解微生物,深入揭示污染物生物降解的生化途径和分子机理,并基于酶催化机理研究对降解酶进行分子改造等;

3)研发功能作物-降解微生物/酶制剂-水肥管理多元素耦合的污染土壤边生产边修复技术体系。

先后主持国家自然科学基金、国家重点研发计划(子课题)、广东省自然科学基金、中国博士后科学基金(含特别资助)等项目课题。在Journal of Hazardous MaterialsEnvironmental InternationalJournal of Agricultural and Food ChemistryBiology and Fertility of SoilsPlant and SoilGeodermaEnvironmental PollutionScience of the Total Environment等高水平TOP期刊发表 SCI 论文50余篇,被引 870余次,h-index=18(截止2020.9);其中以第一/通讯作者发表 SCI论文18 (含中科院一区8篇,二区7),累积影响因子约 100;获授权国家发明专利20余件;参编专著 1 部;担任多个国际主流SCI期刊审稿人;获得广东省土壤学会科技奖 (排名第一) 等;指导(协助)的部分研究生获得广东省优秀研究生、校优秀硕士论文、挑战杯和广东省攀登计划专项资金资助等。


学习经历

工作经历

研究方向

1.植物吸收、转运、积累污染物的生理生化与分子机制研究;

2.典型有机污染物的微生物降解机理与应用、酶蛋白催化机理与分子改造等;

3.污染胁迫下根际微生物互作机制研究。

主要论文

近五年发表的SCI论文:

1Meng C, Du H, Zhao HM*, Li S, Li H, Li YW, Cai QY, Mo CH*.Nitrate supply decreases uptake and accumulation of ciprofloxacin in Brassica parachinensis. Journal of Hazardous Materials. 2020, 2:123803 (*通讯作者, 中科院一区, TOP期刊, IF=9.038)

2Zeng XH, Du H, Zhao HM*, Xiang L, Feng NX., Li H, Mo CH*, He ZL. Insights into the binding interaction of substrate with catechol 2, 3-dioxygenase from biophysics point of view. Journal of Hazardous Materials, 2020, 391, 122211. (*通讯作者, 一区, TOP期刊, IF=9.038)

3Zhao HM, Du H, Huang CQ, Zeng XH, Huang XJ, Xiang L, Li H, Li YW, Cai QY, Mo CH*, He ZL. Bioaugmentation of exogenous strain Rhodococcus sp. 2G can efficiently mitigate DEHP contamination to vegetable cultivation. Journal of Agricultural and Food Chemistry. 2019, 67(25), 6940-6949. (一区, TOP期刊, IF=4.192)

4Zhao HM, Huang HB, Du H, Lin J, Xiang L, Li YW, Cai QY, Li H, Mo CH*, Liu JS, Wong MH. Intraspecific variability of ciprofloxacin accumulation, tolerance, andmetabolism in Chinese flowering cabbage (Brassica parachinensis). Journal of Hazardous Materials. 2018, 349: 252-261. (一区, TOP期刊, IF=9.038)

5Zhao HM, Huang HB, Luo YM, Huang CQ, Du H, Xiang L, Cai QY, Li YW, Li H, Mo CH*, He ZL. Differences in root physiological and proteomic responses to dibutyl phthalate (DBP) exposure between low- and high-DBP accumulation cultivars of Brassica parachinensis. Journal of Agricultural and Food Chemistry, 2018, 66, 51:13541-13551. (一区, TOP期刊, IF=4.192)

6Zhao HM, Huang HB, Du H, Xiang L, Mo CH*, Li YW, Cai QY, Li H, Liu JS, Zhou DM, Wong MH. Global Picture of Protein Regulation in Response to Dibutyl Phthalate (DBP) Stress of Two Brassica parachinensis Cultivars Differing in DBP Accumulation. Journal of Agricultural and Food Chemistry, 2018, 66(18): 4768-4779. (一区, TOP期刊, IF=4.192)

7Zhao HM, Hu RW, Du H, Xin XP, Li YW, Li H, Cai QY, Mo CH*, Liu JS, Zhou DM, Wong MH. Functional genomic analysis of phthalate acid ester (PAE) catabolism genes in the versatile PAE-mineralising bacterium Rhodococcus sp. 2G. Science of the Total Environment, 2018, 640: 646-652. (二区, TOP期刊, IF=6.551)

8Zhao HM, Hu RW, Chen XX, Chen XB, Lü H, Li YW, Li H, Mo CH*, Cai QY, Wong MH. Biodegradation pathway of di-(2-ethylhexyl) phthalate by a novel Rhodococcus pyridinivorans XB and its bioaugmentation for remediation of DEHP contaminated soil. Science of the Total Environment, 2018, 640: 1121-1131. (二区, TOP期刊, IF=6.551)

9Zhao HM, Hu RW, Huang HB, Wen HF, Du H, Li YW, Li H, Cai QY, Mo CH*, Liu JS, Wong MH. Enhanced dissipation of DEHP in soil and simultaneously reduced bioaccumulation of DEHP in vegetable using bioaugmentation with exogenous bacteria. Biology and Fertility of Soils, 2017, 53: 663-675. (一区, TOP期刊, IF=5.521)

10Zhao HM, Xiang L, Wu XL, Jiang YN, Li H, Li YW, Cai QY, Mo CH*, Liu JS, Wong MH. Low-molecular-weight organic acids correlate with cultivar variation in ciprofloxacin accumulation in Brassica parachinensis L. Scientific Reports, 2017, 7:10307. (三区, IF=3.998)

11Zhao HM, Du H, Feng NX, Xiang L, Li YW, Li H, Cai QY, Mo CH*. Biodegradation of di-n-butylphthalate and phthalic acid by a novel Providencia sp. 2D and its stimulation in a compost-amended soil. Biology and Fertility of Soils, 2016, 52(1): 65-76. (一区, TOP期刊, IF=5.521)

12Zhao HM, Du H, Xiang L, Li YW, Li H, Cai QY, Mo CH*, Cao G, Wong MH. Physiological differences in response to di-n-butyl phthalate (DBP) exposure between low-and high-DBP accumulating cultivars of Chinese flowering cabbage (Brassica parachinensis L.). Environmental Pollution, 2016, 208: 840-849. (二区, TOP期刊, IF=6.792)

13Zhao HM, Du H, Xiang L, Chen YL, Lu LA, Li YW, Li H, Cai QY, Mo CH*. Variations in phthalate ester (PAE) accumulation and their formation mechanism in Chinese flowering cabbage (Brassica parachinensis L.) cultivars grown on PAE-contaminated soils. Environmental Pollution. 2015, 206:95-103. . (二区, TOP期刊, IF=6.792)

14Zhao HM, Du H, Lin J, Li H, Cai QY, Mo CH*, Qin HM, Wong MH. Complete degradation of the endocrine disruptor di-(2-ethylhexyl) phthalate by a novel Agromyces sp. MT-O strain and its application to bioremediation of contaminated soil. Science of the Total Environment. 2016, 562: 170–178. (二区, TOP期刊, IF=6.551)

15Zhao HM, Yi X, Hu Z, Hu MY*, Chen SH, Dong XL, Gong L. RNAi-Mediated Knockdown of Catalase Causes Cell Cycle Arrest in SL-1 Cells and Results in Low Survival Rate of Spodoptera litura (Fabricius). PLoS One, 2013, 8(3): e59527. (三区, IF=2.740)

16Zhao HM, Yi X, Deng YY, Hu MY*, Zhong GH, Wang PD. Resistance to fenpropathrin, chlorpyriphos and abamectin in different populations of Amblyseius longispinosus. Biological Control, 2013, 67: 61-65. (二区, IF=2.754)

17Yi X#, Zhao HM#, Wang PD, Hu MY*, Zhong GH. BdorCSP2 is important for antifeed and oviposition-deterring activities induced by Rhodojaponin-III. PloS One 2013, 8(10): e77295. (#共同一作, 三区, IF=2.740)

18Yi X#, Zhao HM#, Dong XL, Wang P, Hu MY*, Zhong GH. Bdor\Orco is important for oviposition-deterring behavior induced by both the volatile and non-volatile repellents in Bactrocera dorsalis (Diptera: Tephritidae). Journal of Insect Physiology. 2014, 65: 51-56. (#共同一作, 二区, IF=2.246)

19Wang JH, Zhao HM, Mo CH, Hou XW. Identification of Differentially Expressed Genes of Rice Under Cadmium Stress Using DDRT-PCR Approach. Bulletin of Environmental Contamination and Toxicology. 2019, 102(4):589-94.

20Xin XP, Zhao FL, Zhao HM, Goodrich SL, Hill MR, Sumerlin BS, Stoffella PJ, Wright AL, He ZL. Comparative assessment of polymeric and other nanoparticles impacts on soil microbial and biochemical properties. Geoderma. 2020, 367:114278.

21Lü H, Mo CH, Zhao HM, Xiang L, Katsoyiannis A, Li YW, Cai QY, Wong MH. Soil contamination and sources of phthalates and its health risk in China: a review. Environmental Research. 2018, 164:417-29.

22Li H, Li X, Xiang L, Zhao HM, Li YW, Cai QY, Zhu L, Mo CH, Wong MH. Phytoremediation of soil co-contaminated with Cd and BDE-209 using hyperaccumulator enhanced by AM fungi and surfactant. Science of the Total Environment. 2018, 613:447-55.

23Xiang L, Li YW, Liu BL, Zhao HM, Li H, Cai QY, Mo CH, Wong MH, Li QX. High ecological and human health risks from microcystins in vegetable fields in southern China. Environment International. 2019, 133:105142.

24Feng NX, Yu J, Mo CH, Zhao HM, Li YW, Wu BX, Cai QY, Li H, Zhou DM, Wong MH. Biodegradation of di-n-butyl phthalate (DBP) by a novel endophytic Bacillus megaterium strain YJB3. Science of the Total Environment. 2018, 616:117-27.

25Xiang L, Xiao T, Yu PF, Zhao HM, Mo CH, Li YW, Li H, Cai QY, Zhou DM, Wong MH. Mechanism and implication of the sorption of perfluorooctanoic acid by varying soil size fractions. Journal of Agricultural and Food Chemistry. 2018, 66(44):11569-79.

26Xiang L, Xiao T, Mo CH, Zhao HM, Li YW, Li H, Cai QY, Zhou DM, Wong MH. Sorption kinetics, isotherms, and mechanism of aniline aerofloat to agricultural soils with various physicochemical properties. Ecotoxicology and Environmental Safety. 2018, 154:84-91.

27Li X, Chen AY, Chen XX, Xiang L, Zhao HM, Mo CH, Li YW, Cai QY, Wong MH, Li H. Effects of β-cyclodextrin on phytoremediation of soil co-contaminated with Cd and BDE-209 by arbuscular mycorrhizal amaranth. Chemosphere. 2019, 220:910-20.

28Xiang L, Li YW, Yu PF, Feng NX, Zhao HM, Li H, Cai QY, Mo CH, Li QX. Food Safety Concerns: Crop Breeding as a Potential Strategy To Address Issues Associated with the Recently Lowered Reference Doses for Perfluorooctanoic Acid and Perfluorooctane Sulfonate. Journal of Agricultural and Food Chemistry. 2019, 68(1):48-58.

29Feng NX, Yu J, Xiang L, Yu LY, Zhao HM, Mo CH, Li YW, Cai QY, Wong MH, Li QX. Co-metabolic degradation of the antibiotic ciprofloxacin by the enriched bacterial consortium XG and its bacterial community composition. Science of The Total Environment. 2019, 665:41-51.

30Xiang L, Chen L, Yu LY, Yu PF, Zhao HM, Mo CH, Li YW, Li H, Cai QY, Zhou DM, Wong MH. Genotypic variation and mechanism in uptake and translocation of perfluorooctanoic acid (PFOA) in lettuce (Lactuca sativa L.) cultivars grown in PFOA-polluted soils. Science of The Total Environment. 2018, 636:999-1008.

31Chen XX, Wu Y, Huang XP, Lü H, Zhao HM, Mo CH, Li H, Cai QY, Wong MH. Variations in microbial community and di-(2-ethylhexyl) phthalate (DEHP) dissipation in different rhizospheric compartments between low-and high-DEHP accumulating cultivars of rice (Oryza sativa L.). Ecotoxicology and Environmental Safety. 2018, 163:567-76.

32Feng NX, Liang QF, Feng YX, Xiang L, Zhao HM, Li YW, Li H, Cai QY, Mo CH, Wong MH. Improving yield and quality of vegetable grown in PAEs-contaminated soils by using novel bioorganic fertilizer. Science of The Total Environment. 2020, 6:139883.

33Li X, Chen AY, Wu Y, Wu L, Xiang L, Zhao HM, Cai QY, Li YW, Mo CH, Wong MH, Li H. Applying β-cyclodextrin to amaranth inoculated with white-rot fungus for more efficient remediation of soil co-contaminated with Cd and BDE-209. Science of The Total Environment. 2018, 634:417-26.

34Li H, Chen XW, Wu L, Luo N, Huang WX, Mo CH, Li YW, Xiang L, Zhao HM, Cai QY, Wong MH. Effects of arbuscular mycorrhizal fungi on redox homeostasis of rice under Cd stress. Plant and Soil. 2020, 17:1-8.

35Xiang L, Li YW, Wang ZR, Liu BL, Zhao HM, Li H, Cai QY, Mo CH, Li QX. Bioaccumulation and Phytotoxicity and Human Health Risk from Microcystin-LR under Various Treatments: A Pot Study. Toxins. 2020, 12(8):523.

36Li M, Li YW, Yu XL, Guo JJ, Xiang L, Liu BL, Zhao HM, Xu MY, Feng NX, Yu PF, Cai QY. Improved bio-electricity production in bio-electrochemical reactor for wastewater treatment using biomass carbon derived from sludge supported carbon felt anode. Science of the Total Environment. 2020, 8:138573.


主要著作

承担课题

近五年主持或参加的科研项目及取得主要的创新点:

1)国家自然科学基金青年项目 (41703085),菜心高/低累积邻苯二甲酸酯特性关键基因的挖掘与功能研究. 24万元,2018.1-2020.12项目主持,在研;

2)广东省自然科学基金面上项目 (2017A030313230),基于基因组学和代谢组学探究Rhodococcus sp. 2G 降解邻苯二甲酸酯(PAEs)的分子机理. 10万元,2017.5-2020.5项目主持,已结题;

该结题项目取得的主要创新点如下:

       ①首次完整地阐述微生物降解代谢PAEs的酶学途径和基因调控网络;

       ②克隆获得3个新的PAEs降解关键基因,它们是酯酶基因Hyd、邻苯二酚双加氧酶基因C23O和原儿茶酸双加氧酶基因PCAase,并分别纯化获得高效降解效率的酶蛋白;

       ③成功对上述三种降解酶进行点突变,鉴定了酶催化功能的关键氨基酸位点,揭示其降解分子机理。

3)中国博士后科学基金特别资助项目 (2018T110924),细胞壁在菜心高/低积累PAEs过程中的分子生理机制研究. 15万元,2018.5-2020.5项目主持,已结题;

该结题项目取得的主要创新点如下:

       ①阐明了细胞壁主要组分 (纤维素、半纤维素、果胶、木质素) PAEs吸附累积的作用机制;

       ②精细刻画了细胞壁主要组分响应PAEs污染胁迫的蛋白/基因调控网络;

       ③克隆获得细胞壁关键基因木葡聚糖内源转糖基酶/水解酶基因XTH,通过基因敲除和过表达验证了该基因在PAEs胁迫下具有重构细胞壁功能,进而影响细胞壁对PAEs的吸附能力;另外发现果胶甲酯化程度也是影响细胞壁吸附累积PAEs的重要因素。

4)中国博士后科学基金面上项目 (2016M602603),脂转移蛋白基因在菜心高/低累积PAEs过程中的功能研究. 5万元,2016.7-2018.7项目主持,已结题.

       ①克隆获得菜心非特异性脂转移蛋白基因nsLTP全长序列,利用Autodock查明了nsLTPDBP 的关键结合位点位于H3H5α螺旋的疏水性口袋中。

通过基因沉默 (RNAi) 技术查明了nsLTP对菜心吸收累积PAEs过程中的贡献,构建了拟南芥nsLTP转基因和突变株系,进一步验证了nsLTP的生理功能。

5NSFC-广东联合基金重点项目 (U1501233),珠三角地区农田土壤有机污染物的环境生物地球化学行为及农艺修复原理. 286万元,2016.1-2019.12,莫测辉教授主持,参加/骨干成员

6)广东省自然科学基金研究团队项目,作物吸收累积邻苯二甲酸酯的基因型差异及其机理研究,2016A030312009300万元,2016.1-2020.12,莫测辉教授主持,参加/骨干成员

7)广东省应用型科技研发重大专项资金,2016B020242005,城市污泥堆肥处理有机污染物及多功能基质(有机肥)研发与应用. 800万元,2016.7-2019.12,莫测辉教授主持,参加/骨干成员


发明专利

近五年申请的国家发明专利申请共计25已获授权21):

1赵海明,莫测辉,李彦文,蔡全英,李慧,冯乃宪,杜欢,向垒,一株可降解多种邻苯二甲酸酯的微杆菌(Microbacterium sp.) J-1,授权日2018-06-01,发明专利号ZL201510066117.4.

2赵海明,莫测辉,李彦文,蔡全英,李慧,林静,杜欢,向垒,一种利用无色杆菌降解邻苯二甲酸二异辛酯的方法,授权日2018-06-05,中国专利号ZL201510066095.1.

3赵海明,莫测辉,蔡全英,李彦文,李慧,林静,杜欢,陈学斌,无色杆菌(Achromobacter sp.) MT-H在降解邻苯二甲酸二异辛酯中的应用,授权日2018-01-23,发明专利号ZL201510066108.5.

4赵海明, 莫测辉,李彦文,蔡全英,李慧,冯乃宪,林静,杜欢,一种利用微杆菌降解邻苯二甲酸酯的方法,授权日2019-02-05,发明专利号ZL201510066128.2.

5赵海明,莫测辉,蔡全英,李彦文,李慧,冯乃宪,杜欢,陈学斌,微杆菌 (Microbacterium sp.) J-1在降解多种邻苯二甲酸酯中的应用,授权日2019-05-07,发明专利号ZL201510066133.3.

6)莫测辉,赵海明,杜欢,蔡全英,李彦文,李慧,一种建立菜心悬浮细胞系的培养方法,授权日2019-10-15,发明专利号ZL201710583067.6.

7)莫测辉,赵海明,黄献培,蔡全英,李彦文,李慧,胡瑞文,黄何彪,杜欢,利用微杆菌J‑1修复DEHP污染土壤并降低种植蔬菜中DEEHP含量的方法,授权日2020-3-17,发明专利号ZL201611200784.8.

8)莫测辉,赵海明,李彦文,蔡全英,李慧,杜欢,林静,冯乃宪,一株可同时降解多种邻苯二甲酸酯的壤霉菌(Agromyces sp.) MT-E,授权日2017-09-01,发明专利号ZL201510066111.7.

9)莫测辉,赵海明,李彦文,蔡全英,李慧,杜欢,向垒,陈学斌,壤霉菌(Agromyces sp.)MT-E在降解多种邻苯二甲酸酯中的应用,授权日2017-10-31,发明专利号ZL201510066068.4.

10)莫测辉,赵海明,李彦文,蔡全英,李慧,杜欢,向垒,林静,一株降解邻苯二甲酸二异辛酯的无色杆菌(Achromobacter sp.) MT-H,授权日2017-12-29,发明专利号ZL201510066134.8.

11)莫测辉,赵海明,蔡全英,李彦文,蔡全英,李慧,杜欢,黄献培,鲁磊安,普罗威登斯菌(Providencia sp.) 2D在邻苯二甲酸二丁酯污染土壤修复中的应用,授权日2018-04-10,发明专利号ZL201510066107.0.

12)莫测辉,赵海明,蔡全英,李彦文,李慧,冯乃宪,杜欢,喻娇,一株高效降解邻苯二甲酸二丁酯的普罗威登斯菌(Providencia sp.) 2D,授权日2018-05-01,发明专利号ZL201510066060.8.

13)蔡全英,莫测辉,赵海明,李彦文,李慧,杜欢,向垒,成玉婷,一种降解多种邻苯二甲酸酯的壤霉菌菌悬液及其应用,授权日2017-11-24,发明专利号ZL201510066106.6.

14)蔡全英,莫测辉,赵海明,李彦文,李慧,杜欢,余忠雄,陈学斌,普罗威登斯菌(Providencia sp.)2D在邻苯二甲酸二丁酯中的应用,授权日2018-02-13,发明专利号ZL201510066089.6.

15)莫测辉,冯乃宪,喻乐意,李彦文,蔡全英,赵海明,李慧,一株溶磷菌及其与DEHP降解菌复合菌剂与在土壤改良中的应用,授权日2020-04-07,发明专利号ZL201810316362.X.

16)莫测辉,冯乃宪,李彦文,蔡全英,喻乐意,李慧,赵海明,一种兼具溶磷和降解DEHP作用的复合菌剂及其应用,授权日2020-04-07,中国,专利号ZL201810317599.X.

17)莫测辉,冯乃宪,李彦文,喻娇,赵海明,蔡全英,李慧,巨大芽孢杆菌YJB3在人工湿地水体PAEs污染净化中的应用,授权日2020-03-05,发明专利号ZL201710735476.3.

18)莫测辉,冯乃宪,喻娇,李彦文,赵海明,向垒,蔡全英,李慧,吴冰霄,一株降解PAEs的植物内生菌及在修复PAEs污染土壤中的应用,授权日2020-03-05,发明专利号ZL201710736090.4.

19)莫测辉,冯乃宪,李彦文,喻娇,赵海明,蔡全英,李慧,佐娜,巨大芽孢杆菌YJB3在促进植物生长和生防中的应用,授权日2020-01-21,发明专利号ZL201710736062.2.

20)向垒,莫测辉,孙腾飞,陈雷,余忠雄,李彦文,蔡全英,李慧,赵海明,黄献培,一种测定作物中全氟羧酸类化合物的方法,授权日2019-05-07,发明专利号ZL201611237800.0.

21)向垒,莫测辉,孙腾飞,陈雷,余忠雄,李彦文,蔡全英,李慧,赵海明,黄献培,一种测定作物可食部分中全氟辛磺酸和全氟己磺酸的方法,授权日2019-05-07,发明专利号ZL201611235705.7.

22)莫测辉,冯宇希,李彦文,蔡全英,赵海明,向垒,李慧,一种用于降解邻苯二甲酸酯的空气过滤装置及方法,申请号CN201810480526.2

23赵海明,黄何彪,莫测辉,杜欢,蔡全英,李彦文,李慧,向垒,一种重组双亚基编码原儿茶酸3,4双加氧酶及其制备方法和应用,申请号CN202010722935.6.

24)杜欢,赵海明,蔡全英,莫测辉,黄何彪,李彦文,李慧,向垒,胡瑞文,一种邻苯二甲酸酯水解酶及其制备方法和应用,申请号CN202010724268.5.

25)杜欢,莫测辉,赵海明,蔡全英,黄雪晶,李彦文,李慧,一种DEHP降解菌剂制备及其有效降低蔬菜生产中DEHP污染的方法,申请号 CN201910161801.9.


讲授课程

荣誉奖励

社会职务