1991/09 - 1994/07，华南理工大学，发酵工程，博士

1988/09 - 1991/07，华南理工大学，发酵工程，硕士

1984/09 - 1988/07，华南理工大学，生物化工，学士

1994/07 - 至今，暨南大学，生命科学技术学院，历任讲师、副教授、教授

1995/10 - 1996/10，日本大阪大学，生物工学国际交流中心，访问学者

2003/08 - 2005/08，美国加州大学伯克利分校，公共卫生学院，访问学者

代表性研究成果

1.Feng L, Sheng J, Vu GP, Liu Y, Foo C, Wu S, Trang P, Paliza-Carre M, Ran Y, Yang X, Sun X, Deng Z, Zhou T, Lu S, Li H（通讯作者）, Liu F.Human cytomegalovirus UL23 inhibits transcription of interferon-γ stimulated genes and blocks antiviral interferon-γ responses by interacting with human N-myc interactor protein.PLoS Pathog. 2018 Jan 29;14(1):e1006867. doi: 10.1371 2018 Jan

2.Liu MY,Liu J,Lai W,Luo J,Liu Y,Vu GP,Yang Z,Trang P,Li H（通讯作者）,Wu J. Characterization of enterovirus 71 infection and associated outbreak of Hand, Foot, and Mouth Disease in Shawo of China in 2012. Sci Rep.2016 Dec 12;6:38451. doi: 10.1038/srep38451

3.Liu H, Wang X, Liu S,Li H, Yuan X, Feng B, Bai H, Zhao B,Chu Y,Li H. Effects and mechanism of miR-23b on glucose-mediated epithelial-to-mesenchymal transition in diabetic nephropathy.Int J Biochem Cell Biol. 2016 Jan;70:149-60

4.Li H（通讯作者）, Ma Y, Chen Y, Sang Y, Zhou T, Qiu M, Huang X, Zhou C, Su Z.A protease-based strategy for the controlled release of therapeutic peptides.Angew Chem Int Ed Engl. 2010 Jul 5;49(29):4930-3

5.Li H , Zhou CX, Su Z . Protease-resistant glucagon like peptide-1 analogs with long-term anti-diabetes type 2 activity.Adv Exp Med Biol. 2009;611:475-6.

6.Li H Li Y, Ni F, Su Z Inhibition of pathogenically-related morphologic transition in Candida albicans by disrupting Cdc42 binding to its effectors.Adv Exp Med Biol. 2009;611:471-2.

7.Li H, Zhou CX, Su JZChemical ligation and cleavage on solid support facilitate recombinant peptide purification.Protein Expr Purif. 2006 Dec;50(2):238-46. Epub 2006 Sep 12.

8.Li H, Trang P, Kim K, Zhou T, Umamoto S, Liu F.Effective inhibition of human cytomegalovirus gene expression and growth by intracellular expression of external Q1 guide sequence2006 RNA Vol.12 No.1 63-72

9.Wang K, Li Y, Zhao G, Wu Y, Zhang X, Li H, Zhou T. Inhibition of human cytomegalovirus DNA replication by small interfering RNAs targeted to UL49.ActaBiochim Biophys Sin (Shanghai). 2013 May;45(5):401-7

10..Bai Y, Gong H, Li H, Vu GP, Lu S, Liu F.Oral delivery of RNase P ribozymes by Salmonella inhibits viral infection in mice.Proc Natl Acad Sci U S A. 2011 Feb 7 22;108(8):3222-7

11.Bai Y, Li H, Vu GP, Gong H, Umamoto S, Zhou T, Lu S, Liu F. Salmonella-mediated delivery of RNase P-based ribozymes for inhibition of viral gene expression and replication in human cells.Proc Natl Acad Sci U S A. 2010 Apr 20;107(16):7269-74

12.Zhang W, Li H, Li Y, Zeng Z, Li S, Zhang X, Zou Y, Zhou T.Effective inhibition of HCMV UL49 gene expression and viral replication by oligonucleotide external guide sequences and RNase P.Virol J. 2010 May 18;7:100

13.Zeng Z, Li H, Li Y, Cui Y, Zhou Q, Zou Y, Yang G, Zhou T.Effective inhibition of human cytomegalovirus gene expression by DNA-based external guide sequences.Acta Biochim Biophys Sin (Shanghai). 2009 May;41(5):389-98

14.Zhou T, Xiao X, Xu B, Li H, Zou Y.Overexpression of SSTR2 inhibited the growth of SSTR2-positive tumors via multiple signaling pathways.Acta Oncol. 2009;48(3):401-10.

15.Bai Y, Trang P, Li H ,Kim K, Zhou T, Liu F. Effective inhibition in animals of viral pathogenesis by a ribozyme derived from RNase P catalytic RNA. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31) :10919-24.

16.Su ZD , Li HJ , Li Y and Ni F, Inhibition of pathogenically-related morphological transition in Candida albicans through intervening interactions of Cdc42 with its effectors: Impact on signal transduction therapy ,Chemistry & Biology (Cell Press), 2007，Nov.14(11):1273-82

17.Guo F, Huang X, Li S, Sun L, Li Y, Li H, Zhou Y, Chu Y, Zhou T.Identification of prosaposin as a novel interaction partner for Rhox5.J Genet Genomics. 2007 May;34(5):392-9

18.Yang YH,Li H, Zhou T, Kim K, Liu F Engineered external guide sequences are highly effective in inducing RNase P for inhibition of gene expression and replication of human cytomegalovirus Nucleic Acids Research,2006, Vol. 34, No.2575-583

19.Zhang WJ, Li HJ , Li YQ, He HK, Tang DS, Zhang X, Zhou TH.Construction of An Effective M1GS Ribozyme Targeting HCMV UL97 mRNA Segment in Vitro.Acta Genetica Sinica, November 2005,32(11),1205-1212

20.Su YZ, Li HJ, Li YQ, Chen HJ, Tang DS, Zhang X, Jiang H, Zhou TH. In Vitro Construction of Effective M1GS Ribozymes Targeting HCMV UL54 RNA Segments. Acta Biochimica et Biophysica Sinica, 2005, 37(3):210-21

会议论文

1. Li Hongjian*（通讯作者） Linyuan Feng , Chingman Foo ,Songbin Wu,Yanhong Ran, Xiaoping Yang, Zemin Deng , Tianhong Zhou. Human cytomegalovirus UL23 protein regulates transcription of interferon-γ stimulated genes</s

1、国家自然科学基金面上项目，31770178，人巨细胞病毒编码蛋白pUL23抑制γ干扰素抗病毒效应的作用机制，2018.1-2021.12。

2、国家“十三五”重大专项，2017ZX10103011-007，珠三角地区儿童传染病重要症候群病原谱及危重症病原特征研究，2017.1-2021.12。

3、广东省自然科学基金重点项目，2016A030311048， SUMO化修饰介导的人巨细胞病毒与γ干扰素途径相互作用的分子机制，2016.6-2019.6。

4、广东省引进创新创业团队项目,2014ZT05S136, 新型抗病毒核酸分子研究团队,2016.1-2021.12（参与）。

5、国家“十二五”重大专项，2013ZX09103003-018，长效胰高血糖素样肽-1（GLP-1）在灵长目动物中药代动力学性质及安全性评价，2013/01-2015/12。

6、广东省重大专项，2012A080202015，2型糖尿病治疗一类新药长效胰高血糖素样肽-1临床前研究，2012/01-2014/12。

7、国家自然科学基金面上项目，81072582，维生素B12介导生物纳米载体口服传递肠促胰岛素多肽药物，2011/01-2013/12。

8、国家“十一五”重大专项，2009ZX09103-606，依赖血浆凝血酶的肽缓释新策略设计优化长效2型糖尿病多肽药物，2009/01-2010/12。

9、科技部973计划项目，2011CB504800，病毒潜伏感染的分子机制，2011/01-2015/12 （参与）。

10、国家自然科学基金面上项目，30770106，人巨细胞病毒蛋白pUL23抑制病毒自身繁殖的分子机理， 2008/01-2010/12。