个人信息

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姓名: 蓝平

部门: 药学院

性别:

职务: 先进与应用化学合成研究院副院长

职称: 副研究员(自然科学)

学位: 博士

毕业院校: 澳大利亚国立大学

联系电话: 02085221367

电子邮箱: ping.lan@jnu.edu.cn

办公地址: 第二理工楼619

通讯地址: 广州市天河区黄埔大道西601号

邮编: 510632

传真:

荣誉奖励:

联系方式

个人简介

蓝平,博士,副研究员,硕士生导师。现任暨南大学先进与应用化学合成研究院副院长。主要研究方向为有机合成化学:包括天然产物全合成以及新型功能配料的研发与制备。目前主持科研项目包括国家自然科学基金青年项目1项,教育部海外名师项目1项,广东省自然科学基金面上项目1项,中央高校科研培育与创新基金1项,广州市企业横向项目3项。截止20199月,共发表SCI收录论文52篇,英文专著2篇,其中第一作者/通讯作者论文28篇,主要发表在Organic Letters, Journal of Organic Chemistry, Journal of Natural Products(天然产物全合成研究成果)和Journal of Colloid and Interface Science, Journal of Agricultural and Food Chemistry(功能配料研究成果)等专业TOP期刊上。


学习经历

2011.10-2015.01 澳大利亚国立大学化学研究院哲学(有机化学)博士

              导师:Martin G. Banwell教授(澳大利亚科学院院士)

              研究方向为天然产物全合成


2008.09-2011.06 暨南大学药学院医学硕士(药物化学专业)

              导师:陈卫民教授

              研究方向为天然产物的结构修饰


2004.09-2008.06 中南民族大学生命科学学院理学学士(药学专业)


工作经历

2019.09至今    暨南大学药学院 副高(绿色通道)

2018.11至今    暨南大学先进与应用化学合成研究院 副院长

2016.12-2019.07 暨南大学理工学院食品科学与工程系 副高(绿色通道)

2015.10-2016.12 澳大利亚沃尔特伊丽莎医学研究所(The Walter and Eliza Hall Institute of Medical Research博士后研究员

              合作导师:Peter M. Colman教授(澳大利亚科学院院士)

              Guillaume Lessene 副教授及Peter Czabotar副教授


              研究方向为化学生物学

2015.02-2015.10 澳大利亚国立大学化学研究院 博士后研究员

              合作导师:Lewis N. Mander教授(澳大利亚科学院院士)

              研究方向为天然产物全合成



研究方向

主要论文

53.

Lan, P.; Ye, S.; Banwell, M. G.* The application of dioxygenase-based   chemoenzymatic processes to the total synthesis of natural products. Chem.   Asian J. published online DOI: 10.1002/asia.2019009889

影响因子(3.698引用次数(0

52.

Li, X.; Hai, Y. W.; Ma, D.; Chen, J.; Banwell, M.   G.; Lan, P.* Fatty acid ester surfactants   derived from raffinose: synthesis, characterization and structure-property profiles.   J. Colloid Interf. Sci. 2019,   556, 616–627.

影响因子(6.361引用次数(0A1二区

51.

Chen, Y.; Chen, W. N.; Hu, N.; Banwell, M. G.; Ma,   C.;Gardiner, M.; Lan, P.* Anticarcinogenic and anti-inflammatory properties of   apigenin-derived isolaxifolin. J. Nat.   Prod. 2019, 82, 2451–2459.

影响因子(4.257引用次数(0A1二区

50.

Sheng, B.; Vo, Y.; Lan, P.; Gardiner M. G.; Banwell, M.   G.*, Sun, P.* The direct and metal-catalyzed photochemical dimerization of   the phthalide (Z)-ligustilide   leading to both [2+2] and [4+2] cycloadducts: application to total syntheses   of tokinolides A-C and riligustilide. Org.   Lett. 2019, 21, 62956299.

影响因子(6.555引用次数(0 A1一区

49.

Lan, P.;   Banwell, M. G.*; Willis, A. C. Application of electrocyclic ring-opening and   desymmetrizing nucleophilic trappings of meso-6,6-dibromobicyclo[3.1.0]hexanes   to total syntheses of crinine and haemanthamine alkaloids. J. Org. Chem. 2019, 84,   3431–3466.

影响因子(4.849引用次数(0 A1二区

48.

Zhang, Z.; Liu, Y.; Chen, Y.*; Li, L.; Lan, P.; He, D.; Song, J.*; Zhang,   Y.* Transdermal delivery of 5-aminolevulinic acid by nanoethosome gels for   photodynamic therapy of hypertrophic scars. ACS Appl. Mater. Inter. 2019,   11, 3704–3714.

影响因子(8.097引用次数(0 A1一区

47.

Mikusek, J.; Nugent, J.; Lan, P.; Banwell, M. G.* A chemical synthesis study establishes   the true structure of the potent anti-inflammatory agent myrsinoic acid F. J. Nat. Prod. 2019, 82, 96–100.

影响因子(4.257引用次数(0 A1二区

46.

Benoit, B.; Tang, F.; Lan, P., Willis, A. C.; Banwell, M. G.* Synthetic studies on the   marine-derived sesquiterpene (+)-viridianol: divergent behaviour of two   structurally related, ring-fused cyclopropanes under the same hydrogenolytic   conditions. Aust. J. Chem.2019, 72, 305–310.

影响因子(1.558引用次数(0 A2四区

45.

Lan, P.;   Banwell, M. G.* Diastereoselective alkylation, allylation and benzylation   reactions (of derived amides). Encyclopedia   of Reagents for Organic Synthesis (e-EROS) 2019, In press

著作章节

44.

Tang, F.; Lan,   P.; Benoit, B.; Banwell, M. G.*; Willis, A. C. Total   synthesis of (+)-viridianol, a marine-derived sesquiterpene embodying the decahydrocyclobuta[d]indene framework. J. Org. Chem. 2018,   83, 1404914056.

影响因子(4.849引用次数(3 A1二区

43.

Yao, N.; Wang, C.; Hu, N.; Li, Y.; Liu, M.;   Lei, Y.; Chen, M.; Chen, L.; Chen, C.; Lan,   P.; Chen, W. M.; Chen, Z.; Fu, D.; Ye, W. C.; Zhang, D. M.* Inhibition of   PINK1/Parkin-dependent mitophagy sensitizes ultidrug-resistant cancer cells   to B5G1, a new betulinic acid analog. Cell  Death Dis. 2019, 10, 232.

影响因子(5.638引用次数(0A1二区

42.

Liang, M. Y.; Banwell, M. G.; Wang, Y.*; Lan, P.* Effect of variations in the fatty acid residue of   lactose monoesters on their emulsifying properties and biological activities.   J. Agric. Food Chem. 2018, 66, 1259412603.

影响因子(3.412引用次数(1A1

41.

Qiu, Y.; Dlugosch, M.; Liu, X.; Khan, F.; Ward, J. S.; Lan, P.; Banwell, M. G.* The   reductive cyclisation of o-nitroarylated-α,β-unsaturated   aldehydes and ketones with TiCl3/HCl or Fe/HCl leading to   1,2,3,9-tetrahydro-4H-carbazol-4-ones   and related heterocycles. J. Org. Chem.2018, 83, 1202312033.

影响因子(4.849引用次数(0A1二区

40.

Moujalled, D.; Pomilio, G.; Ghiurau, C.; Ivery, A.; Salmon, J.; Rijal,   S.; Macraild, S.; Zhang, L.; Teh, T. C.; Tiong, I. S.; Lan, P.; Chanrion, M.; Claperon, A.; Rocchetti, F.; Zichi, A.;   Kraus-Berthier, L.; Wang, Y.; Halilovic, E.; Morris, E.; Colland, F.; Segal,   D.; Huang, D.; Roberts, A. W.; Maragno, A. L.; Lessene, G.; Geneste, O.; Wei.   A.* Combining BH3-Mimetics to target both BCL-2 and MCL1 has potent activity   in pre-clinical models of acute myeloid leukemia. Leukemia2019, 33, 905917.

影响因子(13.164引用次数(12A1

39.

Ma, Y. R.; Banwell, M. G.; Yan, R.*; Lan, P.* Comparative study of the emulsifying properties of a   homologous series of long-chain 6ʹ-O-acylmaltose   esters. J. Agric. Food Chem. 2018, 66, 88328840.

影响因子(3.412引用次数(1A1

38.

Lan, P.; Banwell, M. G.*; Willis, A. C. Total synthesis of (±)-crinane from   6,6-dibromobicyclo[3.1.0]hexane and using a 5-exo-trig radical   cyclisation reaction to assemble the requisite C3a-arylated perhydroindole. J. Org. Chem. 2018, 83, 84938498.

影响因子(4.849引用次数(2A1

37.

Bon, D. J.-Y. D.; Mander, L. N.*; Lan,   P.*Syntheses of gibberellins A15 and A24, the key   metabolites in gibberellin biosynthesis. J.   Org. Chem. 2018,83,   65666572.

影响因子(4.849引用次数(0A1

36.

Xiang, L.; Chen, J.; Yang, Y.; Xie, D.; Li, Y.; Liu, F.; Ma, H.; Wu,   F.; Chen, K.;* Wu, H.; Lan, P.;   Yuan, G.; Li, S.; Wang, Y.; Liu, J.; Zhu, J. Enhanced high permittivity and   lowed dielectric loss in cellulose-fibre framework polymer microcomposites. Polym. Composite. 2019, 40, 15261535.

影响因子(2.324引用次数(0A2三区

35.

Liang, M. Y.; Chen, Y.; Banwell, M. G.; Wang, Y.*; Lan, P.* Enzymatic preparation of a   homologous series of long-chain 6-O-acylglucose   esters and their evaluation as emulsifiers. J. Agric. Food Chem. 2018,   66, 39493956.

影响因子(3.412引用次数(3A1一区

34.

Chen, Y.; Lan, P.* Total Syntheses and   biological evaluation of the Ganoderma lucidum   alkaloids lucidimines B and C.   ACS Omega 2018, 3,34713481.

影响因子(2.584引用次数(1)新期刊,暂无分区

33.

Lan, P.*;   Herlt, A. J.; Willis, A. C.; Taylor, W. C.; Mander, L. N.* Structures of New   Alkaloids from rain forest trees Galbulimima belgraveana and Galbulimima baccata in Papua New Guinea, Indonesia and Northern   Australia. ACS Omega 2018,   3, 19121921.

影响因子(2.584引用次数(1新期刊,暂无分区

32.

Taher, E. S.;   Banwell, M. G.*; Buckler, J. N.; Yan, Q.; Lan, P. The exploitation of enzymatically-derived cis-1,2-dihydrocatechols and related   compounds in the synthesis of biologically active natural products. Chem. Rec. 2018, 18, 239264.

影响因子(3.855引用次数(9A1

31.

Jian, J.; Fan,   J.; Yang, H.; Lan, P.; Li, M.;   Liu, P.; Gao, H.*; Sun, P. H.* Total synthesis   of the flavonoid natural   product Houttuynoid A fromhouttuynia   cordata. J. Nat. Prod. 2018, 81, 371377.

影响因子(3.798引用次数(2A1

30.

Zhao, Q.; Zou, Y.; Huang, C.; Lan,   P.; Zheng, J.; Ou, S.* Formation of a hydroxymethylfurfural-cysteine   adduct and its absorption and cytotoxicity in Caco-2 cells. J. Agric. Food Chem. 2017, 65, 9902–9908.

影响因子(3.412引用次数(4A1

29.

Brouwer, J. M.; Lan, P.; Cowan, A. D.; Bernardini, J.   P.; Birkinshaw, R. W.; van Delft, M. F.; Sleebs, B. E.; Robin, A. Y.; Wardad,   A.; Tan, I. K.; Reljic, B.; Lee, E. F.; Fairlie, W. D.; Call, M. J.; Smith,   B. J.; Dewson, G.; Lessene, G.; Colman, P. M.; Czabotar, P. E.* Conversion of   Bim-BH3 from activator to inhibitor of Bak through structure-based design. Mol. Cell 2017,68, 659672.

影响因子(14.713引用次数(6A1一区

28.

Banwell, M. G.;   Bolte, B.; Buckler, J. N.; Chang, E. L.; Lan,   P.; Taher, E. S.; White, L. V.; Willis, A. C. Chemoenzymatic pathways for   the synthesis of biologically active natural products. Journal and Proceedings of the Royal Society of New South Wales 2016, 149, 3450.

影响因子(1.124引用次数(9A2

27.

Chang, E. L.; Benoit,   B.; Lan, P.; Willis, A. C.;   Banwell, M. G.* Chemoenzymatic total syntheses   of the enantiomers of the protoilludanes 8-deoxydihydrotsugicoline and radudiol.   J. Org. Chem. 2016, 81, 20782086.

影响因子(4.849引用次数(12A1

26.

Lan, P.; White, L. E.;Taher,   E. S.;Guest, P. E.; Banwell, M.   G.*; Willis, A. C. Chemoenzymatic synthesis of (+)-asperpentyn and the   enantiomer of the structure assigned to aspergillusol A. J. Nat. Prod. 2015, 78, 19631968.

影响因子(3.798引用次数(12A1

25.

Lan, P.; Banwell, M. G.*; Willis, A. C. Chemoenzymatic synthesis of the   enantiomer of 4,12-dihydroxysterpurene, the structure assigned to a   metabolite isolated from the culture broth of Stereum purpureum.Org. Lett. 2015, 17, 166169.

影响因子(6.579引用次数(12A1

24.

Crisp,   A. L.; Li, J.; Lan, P.; Nugent,   J.; Matousova, E.; Banwell, M. G.* The Palladium-catalysed intramolecular   Alder-ene (IMAE) reactions of certain heteroatom-linked 1,6-enynes: the   formation of hexahydro-indoles and –benzofurans. Aust. J. Chem.2 015, 68, 11831189.

影响因子(1.558引用次数(8A2

23.

White,   L. V.; Lan, P.; Schwartz, B. D.;   Willis, A. C.; Banwell, M. G.* New, homochiral synthons obtained through   simple manipulations of enzymatically-derived 3-halo-cis-1,2-dihydrocatechols. Aust.   J. Chem. 2015, 68, 14671471.

影响因子(1.558引用次数(5A2

22.

Banwell,   M. G.*; Buckler, J.; Jackson, C. J.; Lan,   P.; Ma, X.; Matousova, E.; Nugent, J. Devising new syntheses of the   alkaloid galanthamine, a potent and clinically deployed inhibitor of   acetylcholine esterase. Strategies   and Tactics in Organic Synthesis 2015, 11, 2950.

著作章节,引用次数(3

21.

Yao, N.; Li, Y. J.; Zhang, D. M.; Liu, D. L.;   Tang, M. K.; Yiu, A.; Li, Y.; Chen, W. M.; Lan, P.; Yao, Z.; Chen, Z. S.; Ye,   W. C.* B4G2 induces mitochondrial apoptosis by the ROS-mediated opening of Ca2+-dependent   permeability transition pores. Cell.   Physiol. Biochem. 2015, 37, 838–852.

影响因子(2.875引用次数(9A1二区

20.

Lan, P.;Jackson,C. J.;Banwell, M.   G.*; Willis, A. C. Synthesis of a D-ring isomer of galanthamine via a radical-based Smiles rearrangement reaction. J. Org. Chem. 2014, 79, 67596764.

影响因子(4.849引用次数(15A1二区

19.

Lan, P.; Banwell,   M. G.*; Willis, A. C. Chemoenzymatic total   syntheses of ribisins A, B and D, polyoxygenated benzofuran derivatives   displaying NGF-potentiating properties. J.   Org. Chem.2014,   79, 28292842.被选为重点推荐论文

影响因子(4.849引用次数(26A1二区

18.

Lan, P.; Banwell,   M. G.*; Ward, J. S.; Willis, A. C. Chemoenzymatic total   synthesis and reassignment of the absolute configuration of ribisin C. Org. Lett. 2014, 16, 228231.

影响因子(6.579引用次数(9A1一区

17.

Zhang,   D. M.; Li, Y. J.; Shu, C.; Ruan, Z. X.; Chen, W. M.; Yiu, A.; Peng, Y. H;   Wang, J.; Lan, P.; Yao, Z.; Fung,   K. P.; Fu, L. W.; Chen, Z. S.*; Ye, W. C.* Bipiperidinyl derivatives of   23-hydroxybetulinic acid reverse resistance of HepG2/ADM and MCF-7/ADR cells.   Anti-Cancer Drugs 2013, 24, 441454.

影响因子(1.784引用次数(8A2三区

16.

Lan, P.;Wu, Z. W.; Chen, W. N.; Sun, P. H.; Chen, W. M.* Molecular   modeling studies on phosphonic acid-containing thiazole derivatives: design   for fructose-1,6-bisphosphatase inhibitors. J. Mol. Model. 2012, 18, 973–990.

影响因子(1.736引用次数(3A2四区

15.

Zhang, D. M.; Shu, C.; Chen, J. J.; Sodani, K.;   Wang, J.; Bhatnagar, J.; Lan, P.;   Ruan, Z. X.; Xiao, Z. J.; Ambudkar, S. V.; Chen, W. M.; Chen, Z. S.*; Ye, W.   C.* BBA, a derivative of 23-hydroxybetulinic acid, potently reverses   ABCB1-mediated drug resistance in vitro   and in vivo. Mol. Pharmaceut.2012, 9, 3147–3159.

影响因子(4.384引用次数(39A1二区

14.

Lan, P.;Wang, J.; Zhang, D. M.; Shu, C.;   Cao, H. H.; Sun, P. H.; Wu, X. M.; Ye, W. C.*; Chen, W. M.* Synthesis andantiproliferative evaluation of 23-hydroxybetulinic acid   derivatives. Eur. J. Med. Chem. 2011, 46, 2490–2502.

影响因子(4.816引用次数(24A1二区

13.

Lan, P.;Chen, W. N.; Chen, W. M.* Molecular modeling studies on   imidazo[4,5-b]pyridine derivatives as Aurora A kinase inhibitors using   3D-QSAR and docking approaches. Eur. J.   Med. Chem. 2011, 46, 77–94.    影响因子(4.816引用次数(38A1二区

12.

Lan, P.;Chen, W. N.; Huang, Z. J.; Sun, P.   H.; Chen, W. M.* Understanding the structure-activity relationship   of betulinic acid derivatives as anti-HIV-1 agents by using 3D-QSAR and   docking. J. Mol. Model.2011, 17, 1643–1659.

影响因子(1.736引用次数(17A2四区

11.

Lan, P.;Sun, J. R.; Chen, W. N.; Sun, P. H.; Chen, W. M.* Molecular   modeling studies on d-annulated   benzazepinones as VEGF-R2 kinase inhibitors using docking and 3D-QSAR. J. Enzym. Inhib. Med. Chem.2011, 26, 367–377.

影响因子(3.638引用次数(8A1二区

10.

Lan, P.;Chen, W. N.; Sun, P. H.; Chen, W. M.* 3D-QSAR and molecular   docking studies of azaindole derivatives as Aurora B kinase inhibitors. J. Mol. Model.2011, 17, 1191–1205.

影响因子(1.736引用次数(11A2四区

9.

Lan, P.;Chen, W. N.; Sun, P. H.; Chen, W. M.* 3D-QSAR studies on   betulinic acid and betulin derivatives as anti-HIV-1 agents using CoMFA and   CoMSIA. Med. Chem. Res.2011, 20,1247–1259.

影响因子(1.402引用次数(4A2四区

8.

Sun, J. R.; Lan, P.; Sun, P. H.; Chen, W. M.* 3D-QSAR   and docking studies on pyrrolopyrimidine derivatives as LIM-Kinase 2 inhibitors.   Lett. Drug Des. Discov.2011, 8, 229240.

影响因子(1.170引用次数(8A2四区

7.

Huang, Z. J.; Zeng, Y.; Lan, P.; Sun, P. H.;   Chen, W. M.* Advances in structural modifications and biological activities   of berberine: an active compound in traditional Chinese medicine. Mini-Rev. Med. Chem.2011, 11, 11221129.

影响因子(2.645引用次数(45A2三区

6.

Song, Q. L.; Guo, B. Q.; Zhang, W.; Lan, P.;Sun, P. H.; Chen,   W. M.* Design, synthesis and antibacterial activity of novel ketolides   bearing an aryltetrazolyl-substituted alkyl side chain. J. Antibiot.2011, 64, 571581.

影响因子(2.150引用次数(6A2三区

5.

Wu, X.; Lan,   P.; Liu, Z.; Ruan, Z. X.; Wang, H.; Wang, G. C.; Ye, W. C.; Li, Y. L.   3D-QSAR studies of natural steroidal saponins as anticancer agents in human   nasopharyngeal carcinoma epithelial cells. Lett. Drug Des. Discov. 2013, 10,   245–252.

影响因子(1.170引用次数(1A2四区

4.

Lan, P.;Xie, M. Q.; Yao, Y. M.; Chen, W. N.; Chen, W. M.* 3D-QSAR   studies and molecular docking on [5-(4-Amino-1H-benzoimidazol-2-yl)-furan-2-yl]-phosphonic acid derivatives as   fructose-1, 6-biphophatase inhibitors. J.   Comput. Aided Mol. Des.2010, 24, 9931008.

影响因子(2.990引用次数(11A2三区

3.

Lan, P.;Chen, W. N.; Xiao, G. K.; Sun, P. H.; Chen, W. M.* 3D-QSAR and docking   studies on pyrazolo[4,3-h]quinazoline-3-carboxamides as cyclin-dependent   kinase 2 (CDK2) inhibitors. Bioorg.   Med. Chem. Lett. 2010, 20, 67646772.

影响因子(2.420引用次数(36A2三区

2.

Lan, P.;Huang, Z. J.; Sun, J. R.; Chen, W. M.* 3D-QSAR and molecular   docking studies on fused pyrazoles as p38α mitogen-activated protein kinase   inhibitors. Int. J. Mol. Sci.2010, 11, 33573374.

影响因子(2.862引用次数(27A2三区

1.

Hu, L.; Lan,   P.;Song, Q. L.; Huang, Z. J.; Sun, P. H.; Zhuo, C.; Wang, Y.; Xiao,   S.; Chen, W. M.* Synthesis and antibacterial activity of C-12 pyrazolinyl   spiro ketolides. Eur. J. Med. Chem.2010, 45, 59435949.

影响因子(3.447引用次数(12A1二区


主要著作

承担课题

7.

基于稠环偕二卤代环丙烷开环反应的活性天然产物全合成研究,广东省自然科学基金面上项目,2019-202210万,主持,编号:2019A1515011281

6.

TBHQ的新型合成工艺研究,横向课题,广东广业清怡食品科技有限公司,2019-202130万,主持

5.

基于稠环偕二卤代环丙烷不对称开环反应的天然产物全合成研究,国家自然科学基金(青年项目),2019-202125万,主持,编号:21801094

4.

功能性食品配料绿色合成研究,教育部海外名师项目, 2018-2023100万,主持,编号:2018-HWMS001

3.

Fissitungfine   A的全合成与抗增殖活性研究,科研培育与创新基金,2017-202015万,主持,编号:21617327

2.

高纯度蔗糖脂肪酸单酯绿色制备研究,横向课题,广州嘉德乐生化科技有限公司,2018-202110万,主持

1.

山苍子精油绿色萃取及综合利用技术开发与产业化示范,广东省扬帆计划引进创新创业团队,2017-2022300万,参与

  


发明专利

3.

蓝平,海耀文,李璇。6-O-酰基棉子糖单酯及其合成方法。中国专利申请:201910520028.02019-06-17.(已受理)

2.

蓝平,汪勇,滕英来,杜木香. 提高木酚素油溶性的改性方法[P]. 中国专利申请:201910547527.9,   2019-06-24. (已受理)

1.

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