个人信息

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姓名: 孙雪松

部门: 生命科学技术学院

直属机构: 生化与分子生物学系(生命与健康工程研究院)

性别:

职务:

职称:

学位: 博士

毕业院校: 香港大学

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电子邮箱: tsunxs@jnu.edu.cn

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个人简介

学习经历

2003-2006: 博士学位香港大学

1999-2002: 硕士学位南开大学/中科院微生物所

1995-1999: 学士学位南开大学

工作经历

2011-现在:暨南大学生命与健康工程研究院,研究员

2008-2011:暨南大学生命与健康工程研究院,副研究员

2007-2008:香港大学, 博士后

研究方向

细菌感染及耐药相关机制的研究

细菌中的金属转运机制

主要论文

1.Cao, K.; Li, N.; Wang, H.; Cao, X.; He, J.; Zhang, B.; He, Q. Y.; Zhang, G.; Sun, X., Two zinc-binding domains in the transporter AdcA from Streptococcus pyogenes facilitate high-affinity binding and fast transport of zinc. J Biol Chem 2018.

2.Liu, Y. T.; Pan, Y.; Lai, F.; Yin, X. F.; Ge, R.; He, Q. Y.; Sun, X., Comprehensive analysis of the lysine acetylome and its potential regulatory roles in the virulence of Streptococcus pneumoniae. J Proteomics 2018, 176, 46-55.

3.Cao, K.; Zhang, J.; Miao, X. Y.; Wei, Q. X.; Zhao, X. L.; He, Q. Y.; Sun, X., Evolution and molecular mechanism of PitAs in iron transport of Streptococcus species. J Inorg Biochem 2018, 182, 113-123.

4.Zhang, L.; Li, N.; Cao, K.; Yang, X. Y.; Zeng, G.; Sun, X.; He, Q. Y., Crucial residue Trp158 of lipoprotein PiaA stabilizes the ferrichrome-PiaA complex in Streptococcus pneumoniae. J Inorg Biochem 2017, 167, 150-156.

5.Yang, X. Y.; He, K.; Du, G.; Wu, X.; Yu, G.; Pan, Y.; Zhang, G.; Sun, X.; He, Q. Y., Integrated Translatomics with Proteomics to Identify Novel Iron-Transporting Proteins in Streptococcus pneumoniae. Front Microbiol 2016, 7, 78.

6.Yang, X. Y.; Zhang, L.; Liu, J.; Li, N.; Yu, G.; Cao, K.; Han, J.; Zeng, G.; Pan, Y.; Sun, X.; He, Q. Y., Proteomic analysis on the antibacterial activity of a Ru(II) complex against Streptococcus pneumoniae. J Proteomics 2015, 115, 107-16.

7.Guo, Z.; Han, J.; Yang, X. Y.; Cao, K.; He, K.; Du, G.; Zeng, G.; Zhang, L.; Yu, G.; Sun, Z.; He, Q. Y.; Sun, X., Proteomic analysis of the copper resistance of Streptococcus pneumoniae. Metallomics 2015.

8.Yang, X. Y.; Zhang, L.; Liu, J.; Li, N.; Yu, G.; Cao, K.; Han, J.; Zeng, G.; Pan, Y.; Sun, X.; He, Q. Y., Proteomic analysis on the antibacterial activity of a Ru(II) complex against Streptococcus pneumoniae. J Proteomics 2014, 115C, 107-116.

9.Yang, X. Y.; Sun, B.; Zhang, L.; Li, N.; Han, J.; Zhang, J.; Sun, X.; He, Q. Y., Chemical interference with iron transport systems to suppress bacterial growth of Streptococcus pneumoniae. PLoS One 2014, 9, (8), e105953.

10.Li, N.; Yang, X. Y.; Guo, Z.; Zhang, J.; Cao, K.; Han, J.; Zhang, G.; Liu, L.; Sun, X.; He, Q. Y., Varied metal-binding properties of lipoprotein PsaA in Streptococcus pneumoniae. J Biol Inorg Chem 2014, 19, (6), 829-38.

11.Yang, X. Y.; Lu, J.; Sun, X.; He, Q. Y., Application of subproteomics in the characterization of Gram-positive bacteria. J Proteomics 2011.

12.Sun, X.; Yang, X. Y.; Yin, X. F.; Yu, G.; Xiao, C. L.; He, X.; He, Q. Y., Proteomic analysis of membrane proteins from Streptococcus pneumoniae with multiple separation methods plus high accuracy mass spectrometry. OMICS 2011, 15, (10), 683-94.

13.Sun, X.; Xiao, C. L.; Ge, R.; Yin, X.; Li, H.; Li, N.; Yang, X.; Zhu, Y.; He, X.; He, Q. Y., Putative copper- and zinc-binding motifs in Streptococcus pneumoniae identified by immobilized metal affinity chromatography and mass spectrometry. Proteomics 2011, 11, (16), 3288-98.

14.Sun, X.; Jia, H. L.; Xiao, C. L.; Yin, X. F.; Yang, X. Y.; Lu, J.; He, X.; Li, N.; Li, H.; He, Q. Y., Bacterial proteome of streptococcus pneumoniae through multidimensional separations coupled with LC-MS/MS. OMICS 2011, 15, (7-8), 477-82.

15.Ge, R.; Sun, X.; Xiao, C.; Yin, X.; Shan, W.; Chen, Z.; He, Q. Y., Phosphoproteome analysis of the pathogenic bacterium Helicobacter pylori reveals over-representation of tyrosine phosphorylation and multiply phosphorylated proteins. Proteomics 2011, 11, (8), 1449-61.

16.Ge, R.; Sun, X.; Wang, D.; Zhou, Q.; Sun, H., Histidine-rich protein Hpn from Helicobacter pylori forms amyloid-like fibrils in vitro and inhibits the proliferation of gastric epithelial AGS cells. Biochim Biophys Acta 2011, 1813, (8), 1422-7.

17.Ge, R.; Sun, X.; He, Q. Y., Overview of the Metallometabolomic Methodology for Metal-Based Drug Metabolism. Curr Drug Metab 2011.

18.Ge, R.; Sun, X., The in vivo functions of a histidine-rich protein Hpn in Helicobacter pylori: linking gastric and Alzheimer's diseases together? Med Hypotheses 2011, 77, (5), 788-90.

19.Ge, R.; Sun, X., Iron trafficking system in Helicobacter pylori. Biometals 2011.

20.Sun, X.; Ge, R.; Zhang, D.; Sun, H.; He, Q. Y., Iron-containing lipoprotein SiaA in SiaABC, the primary heme transporter of Streptococcus pyogenes. J Biol Inorg Chem 2010, 15, (8), 1265-73.

21.Sun, X.; Ge, R.; Cai, Z.; Sun, H.; He, Q. Y., Iron depletion decreases proliferation and induces apoptosis in a human colonic adenocarcinoma cell line, Caco2. J Inorg Biochem 2009, 103, (7), 1074-81.

22.Sun, X.; Baker, H. M.; Ge, R.; Sun, H.; He, Q. Y.; Baker, E. N., Crystal structure and metal binding properties of the lipoprotein MtsA, responsible for iron transport in Streptococcus pyogenes. Biochemistry 2009, 48, (26), 6184-90.

23.Sun, X.; Ge, R.; Chiu, J. F.; Sun, H.; He, Q. Y., Identification of Proteins Related to Nickel Homeostasis in Helicobater pylori by Immobilized Metal Affinity Chromatography and Two-Dimensional Gel Electrophoresis. Met Based Drugs 2008, 2008, 289490.

24.Sun, X.; Ge, R.; Chiu, J. F.; Sun, H.; He, Q. Y., Lipoprotein MtsA of MtsABC in Streptococcus pyogenes primarily binds ferrous ion with bicarbonate as a synergistic anion. FEBS Lett 2008, 582, (9), 1351-4.

主要著作

1.Xuesong Sun, Jen-Fu Chiu, Qing-Yu He, “Fractionation of proteins by immobilized metal affinity chromatography”, Methods Mol. Biol. 2008, 424:205-12.(专著)

2.《功能蛋白质研究》第四、五章,科学出版社,2012

承担课题

1.蛋白质修饰组的高纬度鉴定及功能网络(2017YFA0505100)。国家重点研发计划子课题,80万,2017.7-2022.6

2.结肠癌及其相关巨噬细胞的分泌蛋白质与肿瘤发展的相关研究(2011CB910701)。国家科技部“973” 子课题,36万,

3.肺炎链球菌锌离子摄取关键脂蛋白AdcAAdcAll金属结合特性的研究(21571082)。国家自然基金-面上项目,72万,2016.1-2019.12

4.肺炎链球菌中锰转运蛋白PsaA锰离子结合特性的研究(31000373)。国家自然基金-青年基金,20万,2011.1-2013.12

5.肺炎链球菌新型转铁蛋白UgpB的发现和功能表征(c15140500000642)。广东省自然基金-面上项目,10万,2015-8-2018.8

6.锌蛋白介导的肺炎链球菌锌离子摄取机制的研究(S2012010008685)。广东省自然基金-面上项目,5万,2012-2014.9

7.基于脂蛋白PsaA的肺炎链球菌锰运输机制的研究(10451063201005247)。广东省自然基金-博士启动,3 万,2010.10-2012.9

8.耐药细菌动态磷酸化蛋白质组的研究(201607010228)。广州市科技计划,20万,2016.4-2019.3

9.肺炎链球菌锰摄取机制的研究(33111013)。广州市珠江科技新星计划,30万,2012.1-2013.12

10.肺炎链球菌锰转运机制的研究(21611201)。暨南大学创新与培育项目-杰出人才,60万,2011.1-2013.12

11.肺炎链球菌锰转运机制的研究(51208047)。暨南大学引进人才启动基金,4 万,2008.5-2010.5

12.一种临床耐药菌检测试剂盒的开发。横向课题,10万,2016.1-2018.12

发明专利

讲授课程

功能蛋白质研究

荣誉奖励

社会职务